Zusammenfassung
Das Hyper-IgE-Syndrom (HIES) ist wegen der Beteiligung zahlreicherOrgansysteme, des Krankheitsbeginns im frühen Kindesalter und der wahrscheinlichen Erblichkeit eine Erkrankung, die nicht nur bei Pädiatern, sondern auch bei Dermatologen, HNO-Ärzten, Immunologen und Genetikern Aufmerksamkeit erweckt. Kamen bis zum Jahre 1975 Veröffentlichungen über dieses Krankheitsbild ausschließlich aus den USA, so ist seit 1976 eine Zunahme der Publikationen aus dem europäischen Raum zu verzeichnen. Trotz zunehmendem Interesse an dieser Erkrankung ist es bis heute — 20 Jahre nach der Erstbeschreibung — nicht gelungen, die Pathogenese des Syndroms aufzuklären. Somit fehlen zum einen die Voraussetzungen für eine exakte Abgrenzung des HIES gegenüber anderen Krankheitsbildern ähnlicher Symptomatik, die in der Regel ebenfalls auf Defekten des Immunsystems beruhen, zum anderen fehlt ohne exakte pathogenetische Kenntnisse die Möglichkeit einer gezielten, ggf. sogar kausalen Therapie.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Abramson JD, Dahl MV, Walsh G (1982) Antistaphylococcal IgE in patients with eczema, hyperimmunoglobulinemia E and recurrent infections. J Am Acad Dermatol 7: 105–110
Aiuti F F, Businco L, Fiorilli M et al. (1983) Thymopoietin pentapeptide treatment of primary immunodeficiencies. Lancet 1: 551–555
Aiuti F, Paganelli R, Palmisano L (1983) Complications in primary immunodeficiencies. In: Chandra RK (ed) Primary and secondary immunodeficiency disorders. Livingstone, Edinburgh London Melbourne New York, pp 149–153
Aiuti F, Paganelli R, Le Moli S et al. (1984) Defects of interleukins in immunodeficiencies. In: Griscelli C, Vossen J (eds) Progress in immunodeficiency research and therapy I. Excerpta Medica, Amsterdam New York Oxford, pp 261–266
Ambruso DR, Johnston RB (1983) Defects of phagocyte function. In: Chandra RK (ed) Primary and secondary immunodeficiency disorders. Livingstone, Edinburgh London Melbourne New York, pp 133–148
Armistaed JG, Ewan PW (1983) Suppressor T cell numbers and function in atopic patients with high serum IgE levels. J Clin Lab Immunol 12: 179–185
Baehner RL (1980) Neutrophil dysfunction associated with states of chronic and recurrent infection. Pediatr Clin North Am 27: 337–401
Bale JF, Wilson JF, Hill HR (1977) Fatal histiocytic lymphoma of the brain associated with hyperimmunoglobulinemia E and recurrent infections. Cancer 39: 2386–2390
Barrett D (1983) Deficiency of suppressor T cells in hyperimmunoglobulin E syndrome. In: Oski FA, Stockmann JA III (eds) The year book of pediatrics. Year Book Medical Publishers, Chicago London, pp 109–112
Belohradsky BH (1985) Klinisch anwendbare Immunglobuline. Futuramed, München Immunglobuline. Futuramed, München
Berger M, Kirkpatrick CH, Goldsmith PK, Gallin JI (1980) IgE antibodies to staphylococcus aureus and candida albicans in patients with the syndrome of hyper-immunoglobulin E and recurrent infections. J Immunol 125: 2437–2443
Blum R, Geller G, Fish LA (1977) Recurrent severe staphylococcal infections, eczematoid rash, extreme elevations of IgE, eosinophilia, and divergent chemotactic responses in two generations. J Pediatr 90: 607–609
Brestel EP, Klingberg WG, Veltri RW, Dorn JD (1982) Osteogenesis imperfecta tarda in a child with hyper-IgE syndrome. Am J Dis Child 136: 774–776
Buckley RH (1980) Disorders of the IgE system. In: Stiehm ER, Fulginiti VA (eds) Immunologic disorders in infants and children, 2nd edn. Saunders, Philadelphia London Toronto, pp 274–285
Buckley RH (1980) Immunologic studies in 21 patients with the hyper IgE syndrome. In: Seligmann M, Hitzig WH (eds) Primary immunodeficiencies. Inserm Symposium No 16, Elsevier/North-Holland, New York Oxford, pp 494–496
Buckley RH, Becker WG (1978) Abnormalities in the regulation of human IgE synthesis. Immunol Rev 41: 288–314
Buckley RH, Fiscus SA (1975) Serum IgD and IgE concentrations in immunodeficiency diseases. J Clin Invest 55: 157–165
Buckley RH, Sampson HA (1981) The hyperimmunoglobulinemia E syndrome. In: Franklin EC (ed) Clinical immunology update. Elsevier/North-Holland. New York, pp 147–167
Buckley RH, Wray BB, Belmaker EZ (1972) Extreme hyperimmunoglobulinemia E and undue susceptibility to infection. Pediatrics 49: 59–70
Buckley RH, Sampson HA, Fisher PH, Becker G, Shirley LR (1982) Abnormalities in the regulation of human IgE synthesis. Ann Allergy 49: 67–72
Buckley RH, Gard S, Schiff RI, Sampson HA (1983) T cells and T-cell subsets in a large population of patients with primary immunodeficiency. Birth Defects 19: 187–191
Burdach S EG, Rister M, Evers KG (1981) Membraneigenschaften der Granulozyten bei einem Hiob-Syndrom mit E. coli-Sepsis. Monatsschr Kinderheilkd 129: 229–232
Burgio GR, Nespoli L, Ugazio AG (1978) Atopy as a minimal immunodeficiency? Eur J Pediatr 129: 221–229
Businco L, Laurenti F, Rossi P, Galli E, Aiuti F (1981) Clinical and immunologic studies in a patient with hyper-IgE syndrome treated with levamisole. Arch Dis Child 56: 60–63
Caldwell JH, Sharma AM, Hurtubise PE, Colwell DL (1979) Eosinophilic gastroenteritis in extreme allergy. Gastroenterology 77: 560–564
Cates KL (1981) Defects in neutrophil Chemotaxis. In: Webster ABD (ed) Clinics in immunology and allergy. Saunders, London Philadelphia Toronto, pp 609–614
Charette RP, Hill HR (1982) Clinical conditions associated with depressed Chemotaxis. In: Wedgwood E, Davis SD, Ray CC, Kelley VC (eds) Infections in children. Harper & Row, Philadelphia Cambridge New York, pp 110–111
Chikazawa S, Nunoi H, Endo F, Matsuda I, Honda M (1984) Hyperimmunoglobulin-E-associated recurrent infection syndrome accompanied by chemotactic inhibition of polymorphonuclear leukocytes and monocytes. Pediatr Res 18: 365–369
Church JA, Bellanti JA (1977) Selective food-specific IgE antibodies in a patient with hyperimmunoglobulinemia E recurrent infections and severe eczema. Ann Allergy 39: 137–138
Church JA, Frenkel LD, Wright DG, Bellanti JA (1976) T-lymphocyte dysfunction, hyperimmunoglobulinemia E, recurrent bacterial infections, and defective neutrophil Chemotaxis in a negro child. J Pediatr 88: 982–985
Clark RA, Root RK, Kimball HR, Kirkpatrick CH (1973) Defective neutrophil Chemotaxis and cellular immunity in a child with recurrent infections. Ann Intern Med 78: 515–519
Constantopoulos A, Karpouzas J, Xypolita A, Mandalenaki-Lambrou C, Montsaniotis N, (1978) Defective neutrophil Chemotaxis and hyperimmunoglobulinemia E in a child with recurrent infections. Helv Paediatr Acta 33: 81–84
Czarnetzki BM, Kownatzki E, Dierich M, Frei PC (1983) Chemotaxis: Basic aspects of methodology, mechanisms and pathology. Arch Dermatol Res 275: 359–364
Däumling S, Buriot D, Huu Trung P, Griscelli C, Lalama MC, Belohradsky BH (1980) Das Buckley-Syndrom: Rezidivierende, schwere Staphylokokkeninfektionen, Ekzem und Hyperimmunglobulinämie E. Infection [Suppl] 8 /3: 248–254
Däumling S, Hess J, Griscelli C, Belohradsky BH (1984) Das Hyper IgE-Syndrom. Infektionsimmunologische Charakterisierung von 21 Patienten ( Abstracts ). Monatsschr Kinderheilkd 132: 714
Dahl MV (1983) Staphylococcus aureus und atopic dermatitis. Arch Dermatol 119: 840–846
Dahl MV, Matula C, Leonards R, Tuffanelli DL (1975) Incontinentia pigmenti and defective neutrophil Chemotaxis. Arch Dermatol 111: 1603–1605
Dahl MV, Greene WH, Quie PG (1976) Infection, dermatitis, increased IgE, and impaired neutrophil Chemotaxis. A possible relationship. Arch Dermatol 112: 1387–1390
Davies EG, Levinsky RJ (1984) Natural killer cell activity in primary immunodeficiency diseases. In: Griscelli C, Vossen J (eds) Progress in immunodeficiency research and therapy I. Medica, Amsterdam New York Oxford, pp 117–123
Davis SD, Schaller J, Wedgwood RJ (1966) Job’s syndrome: Recurrent, “cold”, staphylococcal abscesses. Lancet 1: 1013–1015
De Cree J, Emmery L, Timmermans J, Eeckels R, De Cook W, Verhaegen H (1978) Defective neutrophil Chemotaxis and raised serum IgE levels in a child with recurrent bacterial infections and eczema. Influence of levamisole. Arch Dis Child 53: 144–149
Deguchi H, Suemura M, Ishizaka A, Ozaki Y, Kishimoto S, Yamamura Y, Kishimoto T (1983) IgE class-specific suppressor T cells and factors in humans. J Immunol 131: 2752–2756
Donabedian H, Gallin JI (1982) Mononuclear cells from patients with the hyperimmunoglobulin E–recurrent infection syndrome produce an inhibitor of leukocyte Chemotaxis. J Clin Invest 69: 1155–1163
Donabedian H, Gallin JI (1983) The hyperimmunoglobulin E recurrent-infection (Job’s) syndrome. A review of the NIH experience and the literature. Medicine (Baltimore) 62: 195–208
Donabedian H, Allin DW, Gallin JI (1982) Levamisole is inferior to placebo in the hyperimmunoglobulin E recurrent-infection ( Job’s) syndrome. N Engl Med 307: 290–292
Donabedian H, Allin DW, Gallin JI (1982) Levamisole in Job’s syndrome. N Engl J Med 307: 1529
Fanconi S, Seger RA, Willi U, Otto R, Spiess H, Kayser FH, Hitzig WH (1984) Oral Chloramphenicol therapy for multiple liver abscesses in hyperimmunglobulinemia E syndrome. Eur J Pediatr 142: 292–295
Farhoudi A, Harvey BAM, Soothill JF (1978) Clinopathological findings in patients with primary and secondary defects of neutrophil mobility. Arch Dis Child 53: 625–630
Fasth A (1982) Primary immunodeficiency disorders in Sweden: Cases among children, 1974–1979. J Clin Immunol 2: 86–92
Fasth A (1984) Immunodeficiency in children in Sweden: 1974–1983. In: Griscelli C, Vossen J (eds) Progress in immunodeficiency research and therapy I. Excerpta Medica, Amsterdam New York Oxford, pp 461–467
Fontan G, Lorente F, Garcia Rodriguez MC, Ojeda JA (1976) Defective neutrophil Chemotaxis and hyperimmunoglobulinemia E-a reversible defect? Acta Paediatr Scand 65: 509–511
Foster SC, Goetzl EJ (1978) Ascorbate therapy in impaired neutrophil and monocyte Chemotaxis. Arch Ophthalmol 96: 2069–2072
Friedenberg WR, Marx JJ, Hansen RL, Haselby RC (1979) Hyperimmunoglobulin E syndrome: Response to transfer factor and ascorbic acid therapy. Clin Immunol Immunopathol 12: 132–142
Gahr M, Ranti J, Schröter W (1978) A new defect of neutrophil Chemotaxis and random motility in a child with recurrent bacterial infections and hyperimmunoglobulinemia E. Eur J Pediatr 127: 173–179
Gaither TA, Gallin JI, Iida K, Nussenzweig V, Frank MM (1984) Deficiency in C3b receptors on neutrophils of patients with chronic granulomatous disease and hyperimmunoglobulin-E recurrent infection ( Job’s) syndrome. Inflammation 8: 429–444
Gallin JI (1980) Disorders of phagocyte Chemotaxis. NIH conference. Ann Intern Med 92: 520–538
Gallin JI (1981) Abnormal phagocyte Chemotaxis: Pathophysiology, clinical manifestations and management of patients. Rev Infect Dis 3 /6: 1196–1220
Geha RS, Reinherz E, Leung D, McKee KT, Schlossman S, Rosen FS (1981) Deficiency of suppressor T cells in the hyperimmunoglobulin E syndrome. J Clin Invest 68: 783 — 791
Gerbeaux J, Baculard A, Tournier G, Moulias R, Goust J-M, Drouhet E, Saint-Martin J (1975) Déficit partiel de l’immunité à méditation cellulaire chez un enfant atteint de Candidose cutanéomuqueuse chronique. Cryptococcose pulmonaire et méningée intercurrente. Ann Méd Interne (Paris) 10: 615–625
Gillet P, Phillipe N, Philip T (1979) Infection récidivante, éczéma, atopique, défizit du chimiotactisme et hyper IgE sérique-à propos d’une observation chez un garçon de 5 ans. Nouv Rev Fr Hématol 21: 53
Goldman AS, Lord RA, Dupree E, Goldblum RM, Smith CW, Dahl EV (1974) Lack of suppression of certain immunoglobulin-producing lymphocytes in T-lymphocyte deficiency. Clin Immunol Immunopathol 3: 69–78
Gottlieb BR, Hanifîn JM (1974) Circulating T-cell deficiency in atopic dermatitis. Clin Res 22: 159A
Gupta S (1981) Subpopulations of human T-lymphocytes. XVIII. T-lymphocytes with receptors for IgE (Ta) in patients with primary immunodeficiency and hyperimmunoglobulinaemia E states. Clin Exp Immunol 45: 113–117
Haneke E, Djawari D (1982) Hyperimmunglobulin E-Syndrom: Atopisches Ekzem, Eosinophilie, Chemotaxisdefekt. Infektanfälligkeit und chronische mucocutane Candidose. Aktuel Dermatol 8: 34–39
Hayakawa H (1982) The immunodeficiency syndrome. Asian Med J 25: 278–285
Hayakawa H, Iwata T, Yata J, Kobayashi N (1981) Primary immunodeficiency syndrome in Japan. I. Overview of a nationwide survey on primary immunodeficiency syndrome. J Clin Immunol 1: 31–39
Hénocq E, Hewitt B, Guerin B (1982) Staphylococcal and human IgE antibodies in superinfected atopic dermatitis. Clin Allergy 12: 113–120
Hill HR (1982) The syndrome of hyperimmunglobulinemia E and recurrent infections. Am J Dis Child 136: 767–771
Hill HR, Quie PG (1974) Raised serum-IgE levels and defective neutrophil Chemotaxis in three children with ekzema and recurrent bacterial infections. Lancet 1: 183–187
Hill HR, Quie PG (1974) Defective neutrophil Chemotaxis, severe staphylococcal infection and hyperimmunoglobulinemia E. Pediatr Res 8: 426
Hill HR, Quie PG (1974) Impaired neutrophil granulocyte Chemotaxis, recurrent bacterial and fungal infections and hyperimmunoglobulinemia E. Clin Res 22: 229
Hill HR, Ochs HD, Quie PG, Clark RA, Pabst HF, Kebanoff SJ, Wedgwood RJ (1974) Defect in neutrophil granulocyte Chemotaxis in Job’s syndrome of recurrent “cold” staphylococcal abscesses. Lancet 1: 617–619
Hill HR, Estensen RD, Hogan NA, Quie PG (1976) Severe staphylococcal disease associated with allergic manifestations, hyperimmunoglobulinemia E, and defective neutrophil Chemotaxis. J Lab Clin Med 88: 796–806
Huu Trung P, Oury C, Däumling S, Buriot D, Belohradsky BH, Griscelli C (1982) Syndrome de susceptibilité aux infections avec hyper IgE. Arch Fr Pediatr 39: 353–358
Ishikawa I, Fukuda Y, Kitada H et al. (1982) Plasma exchange in a patient with hyper-IgE syndrom. Ann Allergy 49 /5: 295–297
Tssekutz AC, Lee KY, Biggar WD (1978) Neutrophil Chemotaxis in two patients with recurrent staphylococcal skin infections and hyperimmunoglobulin E. J Lab Clin Med 92: 640–647
Jacobs JC, Norman ME (1977) Familial defect of neutrophil Chemotaxis, with asthma, eczema, and recurrent skin infection. Pediatr Res 11: 732–736
Jeune R, Faure M, Leung-Tack J (1978) Defective leukocytotaxia and recurrent staphylococcal infection. Arch Dermatol 114: 1372–1378
Josephs SH, Buckley RH (1980) Serum IgD concentration in normal infants, children, and adults and in patients with elevated IgE. J Pediatr 96: 417–420
Jung LKL, Kapoor N, Engelhard D, Pih K, Good RA (1983) Pyoderma, eczema, and follikulitis with defective leukocyte and lymphocyte function: A new familial immunodeficiency disease responsive to a histamine–1 antagonist. Lancet 1: 185–187
Katona IM, Tata G, Scanion RT, Bellanti JA (1980) Hyper IgE syndrome: A disease with suppressor T cell deficiency. Ann Allergy 45: 295–300
Katz DH (1984) Regulation of the IgE-system: Experimental and clinical aspects. Allergy 39: 81–106
Kesarwala HH, Prasad RVSK, Szep R, Oldman E, Lane S, Papageorgiou PS (1979) Transfer factor therapy in hyperimmunoglobulinemia E syndrome. Clin Exp Immunol 36: 465–472
Koch C, Andersen V, Faber V, Friis B, Pedersen FK, Platz P (1981) Registration of primary immunodeficiencies. Ugeskr Laeger 143: 2479–2484
Komiyana A, Morosawa H, Manamura K, Miyagawa Y, Akabane T (1977) Defective neutrophil Chemotaxis, hyperimmunoglobulinemia and impair cellular immunity in a child with recurrent pyogenic infections and chronic eczema. Acta Haematol Jpn 40: 513–539
Kraemer MJ, Ochs HD, Furukawa CT, Wedgwood RJ (1982) In vitro studies of the hyper-IgE disorders: Suppression of spontaneous IgE synthesis by allogeneic suppressor T-lymphocytes. Clin Immunol Immunopathol 25: 157–164
Lallemand D, Buriot D, Griscelli C, Kalifa G, Sauvergrain J (1979) Anomalies osseuses constitutionelles dans les déficits immunitaires congénitaux. Ann Radiol 22: 108–118
Laurent J, Lagrue G, Dubertret L, Branellec A (1983) Syndrome d’hyperimmunoglobulinémia E avec infections récurrentes (syndrome de Buckley) associé à une glomérulonephrite membranoproliferative. Presse Méd 12: 1005–1007
Leyh F, Wendt V, Otte J (1984) Lupus erythematodes in Kombination mit Hyper-IgE-Syndrom ( Abstracts ). Monatsschr Kinderheilkd 132: 701
Lipinski M, Virelizier JL, Tursz T, Griscelli C (1980) Natural killer cells and killer cell activities in patients with primary immunodeficiencies or defects in interferon production. Eur J Immunol 10: 246–249
Luzi G, Businco L, Aiuti F (1983) A national registry for primary immunodeficiency syndromes in Italy: A report for the period 1972–1982. Birth Defects 19: 161–163
Matsumoto T, Gotoh Y, Narukami H, Miyamoto V, Honda M (1981) Case report: A hyperimmunoglobulin E syndrome with serum inhibitor against immune functions. Ann Allergy 46: 86–91
Mawhinney H, Killen M, Fleming WA, Roy AD (1980) The hyperimmunoglobulin E syndrome–a neutrophil chemotactic defect reversible by histamine H2 receptor blockade? Clin Immunol Immunopathol 17: 483–491
Merten DF, Buckley RH, Pratt PC, Effmann EL, Grossman H (1979) Hyperimmunoglobulinemia E syndrome: Radiographic observations. Radiology 132: 71–78
Miller ME (1975) Pathology of Chemotaxis and random mobility. Sem Hematol 12: 59–82
Ochs HD, Kraemer MJ, Landgren CG, Furukawa CT, Wedgood RJ (1983) Immune regulation in the hyper-IgE/Job syndrome. Birth Defects 19: 57–61
Ortega JJ, Félin E, Espanol T, Cardellach F (1980) Hiperimmunoglobulinemia E y quiemiotaxis defectuosa asociadas a infecciones bacteriamas récurrentes y asma. Sangra 25: 231–239
Pabst HF, Holmes B, Quie PG, Gewürz H, Rodey G, Good RA (1971) Immunological abnormalities in Job’s syndrome. Pediatr Res 6: 380
Paslin D, Norman ME (1977) Atopic dermatitis and impaired neutrophil Chemotaxis in Job’s syndrome. Arch Dermatol 113: 801–805
Patrone F, Dallegri F, Rebora A (1979) Defective neutrophil Chemotaxis and bactericidial power in a child with hyperimmunoglobulinemia E. Eur J Pediatr 180: 181–187
Perraudin ML. Larregue M, Huu Trung P, Desbois JC, Herrault A (1980) Infections recidivantes avec hypergammaglobulinemie E, syndrome de Buckley. Nouv Presse Med 9:1571–1575
Pincus SH, Thomas IT, Clark RA, Ochs HD (1975) Defective neutrophil Chemotaxis with variant ichthyosis, hyperimmunoglobulinemia E, and recurrent infections. J Pediatr 87: 908–911
Pohl P (1983) Differentialdiagnose von Abwehrdefekten. In: Huber H, Pastner D, Gabi F (Hrsg) Hämatologie und Immunhämatologie. Springer, Berlin Heidelberg New York Tokyo, S 200–234
Quie PG (1983) Hyperimmunglobulin E recurrent infection (Job) syndrome. In: Behrman RE, Vaughan VC III, Nelson WA (eds) Textbook of pediatrics. Saunders, Philadelphia London Toronto Mexico City Rio de Janeiro Sydney Tokyo, p 522
Quie PG (1983) Infections in patients with abnormal granulocyte Chemotaxis. In: Gigli IN, Miescher PA, Müller-Eberhard HJ (eds) Immunodermatology. Springer, Berlin Heidelberg New York Tokyo, pp 117–128
Raynor RH, Wray BB, Brown WG, Scott DF, Best GK (1980) Neutrophil function studies in patients with elevated serum IgE levels and recurring staphylococcus aureus infections. Clin Immunol Immunopathol 17: 372–381
Rebora A, Patrone F (1978) Hyperimmunoglobulinemia E syndrome. Arch Dermatol 114: 1854
Rebora A, Nunzi E, Pezzuolo M, Patrone F, Dallegri F, Sacchetti C (1978) Buckley’s syndrome. Br J Dermatol 99: 569–572
Repine JE, Clawson CC, Brunning RD (1976) Primary leukocyte alkaline phosphatase deficiency in an adult with repeated infections. Br J Haematol 34: 87–94
Rister M, Horatz M (1981) Adhärenz und Chemotaxis kindlicher Granulozyten. Klin Pädiatr 193: 46–49
Rogge JL, Hanifin JM (1976) Immunodeficiencies in severe atopic dermatitis. Depressed Chemotaxis and lymphocyte transformation. Arch Dermatol 112: 1391–1396
Romagnani S, Maggi E, del Prete GF, Ricci M (1983) IgE synthesis in vitro induced by T cell factors from patients with elevated serum IgE levels. Clin Exp Immunol 52: 85–88
Sacchi FT, Ferrari FA, Fortunato A, Maggiore G, Marconi H, Pagani A, Siccardi AG (1979) A defect in neutrophil motility in two siblings with recurrent infections and a remarkable family history. Infection 7: 45–47
Saryan JA, Leung DYM, Geha RS (1983) Induction of human IgE synthesis by a factor derived from T–cells of patients with hyper–IgE states. J Immunol 130: 242–247
Schmitt C, Ballet JJ (1983) Serum IgE and IgG antibodies to tetanus toxoid and candida in immunodeficient children with the hyper–IgE syndrome. J Clin Immunol 3: 178–183
Schopfer K (1984) Le syndrome de susceptibilité aux infections avec hyper-IgE. In: Griscelli C, Hitzig W (eds) Déficits immunitaires congénitaux et acquis. Doin, Paris, pp 141–156
Schopfer K, Baerlocher K, Price P, Krech U, Quie PG, Douglas SD (1979) Staphylococcal IgE antibodies hyperimmunoglobulinemia E and staphylococcus aureus infections. N Engl J Med 300: 835–838
Schopfer K, Douglas SD, Wilkinson BJ (1980) Immunoglobulin E antibodies against staphylococcus aureus cell walls in the sera of patients with hyperimmunoglobulinemia E and recurrent staphylococcal infection. Infect Immunol 27: 563–568
Schopfer K, Feldges A, Baerlocher K, Porisot RF, Wilhelm JA, Matter L (1983) Systemic lupus erythematosus in staphylococcal aureus hyperimmunglobulinemia E syndrome. Br Med J 287: 524–526
Sheagren JN (1984) Staphylococcus aureus. The persistent pathogen. N Engl J Med 310: 1368–1373
Smithwick EM, Finelt M, Pahwa S, Good RA (1978) Cranial synostosis in Job’s syndrome. Lancet 1: 826
Snyderman R, Buckley RH (1975) Defects of monocyte Chemotaxis in patients with hyperimmunoglobulinemia E and undue susceptibility to infections. J Allergy Clin Immunol 55: 102–103
Soderberg-Warner M, Price-Mendoza CA, Mendoza GR, Stiehm ER (1983) Neutrophil and T–lymphocyte characteristics of two patients with hyper-IgE-syndrome. Pediatr Res 17: 820–824
Spector BD, Perry GS III, Kersey JH (1978) Genetically determined immunodeficiency diseases ( GDID) and malignancy: Report from the immunodeficiency-cancer registry. Clin Immunol Immunopathol 11: 12–29
Stanley J, Perez D, Gigli I, Goldstein I, Baer RL (1978) Hyperimmunoglobulin E syndrome. Arch Dermatol 114: 765–767
Swim AT, Bradac C, Craddock PR (1982) Levamisole in Job’s syndrome. N Engl J Med 307: 1528–1529
Tonnel AB, Joseph M, Gosselin B, Gösset P, Fournier E (1983) Pneumatocêle surinfectée, éosinophilie et hyperproduction dTgE révélatrices d’un syndrome de Buckley à 1’ age adulte. Poumon Coeur 39: 95–100
Van der Meer JWM, van den Broek PJ (1984) Present status of the management of patients with defective phagocyte function. Rev Infect Dis 6: 107–121
Van Epps DE, El-Naggar A, Ochs HD (1983) Abnormalities of lymphocyte locomotion in immunodeficiency disease. Clin Exp Immunol 53: 678–688
Vanheule R, De Cree J, Adriaenssens K, De Hauwere R (1976) Levamisole therapy for cellular immunologic deficiency with high IgE values. Acta Paediatr Belg 29: 41–46
Van Scoy RE, Hill MR, Ritts RE (1975) Familial neutrophil Chemotaxis defect, recurrent bacterial infections, mucocutanous candidiasis, and hyperimmunoglobulinemia E. Ann Intern Med 82: 766–771
Viniaker H, Moneret-Vautrin DA, Le Van Diem, Grilliat J (1976) Taux élevé d’IgE, hyperéosinophilie et déficit de l’immunité cellulaire. Ann Méd Nancy 3: 225–229
Waldmann TA, Wochner RD, Laster L, Gordon RS (1967) Allergie gastroenteropathy. A cause of excessive gastrointestinal protein loss. N Engl J Med 276: 761–769
Weening RS, Stricker L, Roos D, Molenaar JL, Dooren LJ, Schuurman RKB (1977) Restoration of the neutrophil chemotactic responsiveness by levamisole treatment in patients with recurrent infections, eczema and hyperimmunoglobulinaemia E. In: Willoughby DA, Giroud JP, Velo GP (eds) Perspectives in inflammation. MTP Press, Lancaster, pp 445–454
Wenning J, Stengel R, Kunze J, Schöpf E (1981) Hyperimmunglobulin E-Syndrom. In: Z. Kölner-RAST-Symposion 1979. Grosse, Berlin, S 74–78
Weston WL, Humbert JR, August CS, Harnett J, Hass MF, Dean PB, Hagen IM (1977) A hyperimmunoglobulin E syndrome with normal Chemotaxis in vitro and defective leukotaxis in vivo. J Allergy Clin Immunol 59: 115–119
Wright DG, Kirkpatrick CH, Gallin JI (1977) Effects of levamisole on normal and abnormal leukocyte locomotion. J Clin Invest 59: 941–950
Wyre HW, Johnson WT (1978) Clinical syndrome of Chemotaxis defect, infections, and hyperimmunoglobulinemia E. Arch Dermatol 114: 74–77
Yegin O (1983) Chemotaxis in childhood. Pediatr Res 17: 183–187
Zankovich R, Schell-Frederick E, Diehl V (1985) Chronisch granulomatöse Erkrankung und Job–Syndrom: Ein primärer Defekt der Phagozytenfunktion. Dtsch Ärztebl 82: 1257–1263
Belohradsky BH (1986) Primäre Immundefekte. Klinik Immunologie and Genetik. W. Kohlkammer Verlag, Stuttgart Mainz Köln Berlin
Author information
Authors and Affiliations
Editor information
Additional information
Professor Dr. Walter H. Hitzig in Verehrung gewidmet
Rights and permissions
Copyright information
© 1987 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Belohradsky, B.H., Däumling, S., Kiess, W., Griscelli, C. (1987). Das Hyper-IgE-Syndrom (Buckley- oder Hiob-Syndrom). In: Frick, P., von Harnack, GA., Kochsiek, K., Martini, G.A., Prader, A. (eds) Ergebnisse der Inneren Medizin und Kinderheilkunde/Advances in Internal Medicine and Pediatrics. Ergebnisse der Inneren Medizin und Kinderheilkunde/Advances in Internal Medicine and Pediatrics, vol 55. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71052-0_1
Download citation
DOI: https://doi.org/10.1007/978-3-642-71052-0_1
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-71053-7
Online ISBN: 978-3-642-71052-0
eBook Packages: Springer Book Archive