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Atherosclerosis, Social Dominance and Cardiovascular Reactivity

  • Conference paper
Biological and Psychological Factors in Cardiovascular Disease

Abstract

Animal models play an important role in the study of atherogenesis because, under suitable dietary conditions, many species develop atherosclerotic lesions more rapidly than do human beings. In addition, use of animals permits experimental manipulation of pertinent environmental variables, as well as a more precise quantification of lesion characteristics (e.g., size, composition) than is feasible in clinical studies of human subjects. Moreover, among vertebrate species the nonhuman primates - in particular, Old World monkeys - have attracted the greatest interest of atherosclerosis researchers. Old World primates do not develop extensive atherosclerosis in their natural environments, yet all are susceptible to diet-induced hyperlipoproteinemia and the resulting patterns of atherosclerosis are similar, in many species, to those seen in human beings. Of the Old World monkeys, the macaques, especially rhesus and cynomolgus monkeys, are considered to be exceptionally useful models. This is due not only to the fact that the characteristics of lesions seen in these species closely resemble important features of human atherosclerosis, but also to pragmatic considerations such as the macaque’s convenient size, commercial availability, and acceptance of experimental diets (Kaplan et al. 1985).

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References

  • Altmann J (1974) Observational study of behavior: sampling methods. Behaviour 48: 1–41

    Article  Google Scholar 

  • Armstrong ML, Megan MB (1975) Arterial fibrous proteins in cynomolgus monkeys after atherogenic and regression diets. Circ Res 36: 256–261

    PubMed  CAS  Google Scholar 

  • Armstrong ML, Trillo A, Prichard RW (1980) Naturally occurring and experimentally induced atherosclerosis in nonhuman primates. In: Kalter SS (ed) The use of nonhuman primates in cardiovascular diseases. University of Texas Press, Austin

    Google Scholar 

  • Barefoot JJC, Dahlstrom WC, Williams RB (1983) Hostility, CHD incidence, and total mortality: a 25-year follow-up study of 255 physicians. Psychosom Med 45: 59–63

    PubMed  CAS  Google Scholar 

  • Beere PA, Glagov S, Zarins CK (1984) Retarding effect of lowered heart on coronary atherosclerosis. Science 226: 180–182

    Article  PubMed  CAS  Google Scholar 

  • Bernstein IS (1970) Primate status hierarchies. In: Rosenblum LA (ed) Primate behavior: developments in field and laboratory research, vol I. Academic, New York

    Google Scholar 

  • Bernstein IS, Gordon TP, Rose RM (1974) Aggression and social controls in rhesus monkey ( Macaca mulatta) groups revealed in group formation studies. Folia primatol 21: 81–107

    Google Scholar 

  • Bond MD, Bullock BC, Bellinger DA, Hamm TE (1980) Myocardial infarction in a large colony of nonhuman primates with coronary artery atherosclerosis. Am J Pathol 101: 675–692

    PubMed  CAS  Google Scholar 

  • Clarkson TB (1980) Symposium summary. In: Kalter SS (ed) The use of nonhuman primates in cardiovascular diseases. University of Texas Press, Austin

    Google Scholar 

  • Clarkson TB (1984) Implications for atherogenesis. In: Stress, reactivity, and cardiovascular disease. NIH, Bethesda, (publication no 84–2698 )

    Google Scholar 

  • Dembroski TM, MacDougall JM, Shields JL, et al (1978) Components of the Type A coronary-prone behavior pattern and cardiovascular responses to psychomotor performance challenge. J Behav Med 1: 159–176

    Article  PubMed  CAS  Google Scholar 

  • Freeman MF, Tukey JW (1950) Transformations related to the angular and the square root. Ann Math Stat 21: 607–611

    Article  Google Scholar 

  • Hamm TE, Kaplan JR, Clarkson TB, Bullock BC (1983) Effects of gender and social behavior on the development of coronary artery atherosclerosis on cynomolgus macaques. Atherosclerosis 48: 221–233

    Article  PubMed  Google Scholar 

  • Henry JP (1983) Coronary heart disease and arousal of the adrenal cortical axis. In: Dembroski TM, Schmidt TH, Blümchen G (eds) Biobehavioral bases of coronary heart disease. Karger, Basel

    Google Scholar 

  • Herd JA (1983) Physiological basis for behavioral influences in atherosclerosis. In: Dembroski TM, Schmidt TH, Blümchen G (eds) Biobehavioral bases of coronary heart disease. Karger, Basel

    Google Scholar 

  • Hirsch EZ, Maksem JA, Gagen D (1984) Effects of stress and propranolol on the aortic intima of rats. Arteriosclerosis 4: 526 (abstract)

    Google Scholar 

  • Kaplan JR, Manuck SB, Clarkson TB, Lusso FM, Taub DB (1982) Social status, environment, and atherosclerosis in cynomolgus monkeys. Arteriosclerosis 2: 359–368

    Article  PubMed  CAS  Google Scholar 

  • Kaplan JR, Manuck SB, Clarkson TB, Lusso FM, Taub DB, Miller EW (1983) Social stress and atherosclerosis in normocholesterolemic monkeys. Science 220: 733–735

    Article  PubMed  CAS  Google Scholar 

  • Kaplan JR, Manuck SB, Clarkson TB, Pritchard RW (1985) Animal models of behavioral influences on atherogenesis. In: Katkin ES, Manuck SB (eds) Advances in behavioral medicine, vol I. J AI, Greenwich (unpublished)

    Google Scholar 

  • Kawai M (1958) On the rank system in a natural group of Japanese macaques. Primates 1: 84–98

    Article  Google Scholar 

  • Kramsch DM, Hollander W (1968) Occlusive atherosclerotic disease of the coronary arteries in monkeys ( Macaca irus)induced by diet. Exp Mol Pathol 9: 1–22

    Google Scholar 

  • Krantz DS, Manuck SB (1984) Acute psychophysiologic reactivity and risk of cardiovascular disease: a review and methodologic critique. Psych Bull 96: 435–464

    Article  CAS  Google Scholar 

  • Lancaster J (1975) Primate behavior and the emergence of human culture. Holt, Rinehart and Winston, New York

    Google Scholar 

  • Malinow MR, McLaughlin P, Papworth L, Nato HK, Lewis L, McNully WP (1976) A model for therapeutic interventions on established coronary atherosclerosis in a nonhuman primate. Adv Exp Biol Med 67: 3–31

    CAS  Google Scholar 

  • Manuck SB, Krantz DS (1984) Psychophysiologic reactivity in coronary heart disease. Behav Med Update 6: 11–15

    Google Scholar 

  • Manuck SB, Kaplan JR, Clarkson TB (1983) Behaviorally-induced heart rate reactivity and atherosclerosis in cynomolgus monkeys. Psychosom Med 45: 95–108

    PubMed  CAS  Google Scholar 

  • Manuck SB, Proietti JM, Rader SJ, Polefrone JM (1985) Parental hypertension, affect and cardiovascular response to cognitive challenge. Psychosom Med 47: 189–200

    PubMed  CAS  Google Scholar 

  • Matthews KA, Jamison JW, Coddington EM (1985) Assessment of type A, anger and hostility: a review of measures through 1982. Proceedings of the NHLBI workshop. In: Measuring psychosocial variables in epidemiologic studies of cardiovascular disease. NIH, Bethesda (to be published)

    Google Scholar 

  • Review Panel (1981) Coronary-prone behavior and coronary heart disease: a critical review. Circulation 19: 583

    Google Scholar 

  • Ross R (1981) Atherosclerosis: a problem of the biology of arterial wall cells and their interactions with blood components. Arteriosclerosis 1: 293–311

    Article  PubMed  CAS  Google Scholar 

  • Rudel LL, Pitts LL (1978) Male-female variability in the dietary cholesterol-induced hyperlipoproteinemia of cynomolgus monkeys ( Macaca fascicularis ). J Lipid Res 19: 992–998

    Google Scholar 

  • Sade DS (1967) Determinants of dominance in a group of free ranging rhesus monkeys. In: Altman S (ed) Social communication among primates. University of Chicago Press, Chicago

    Google Scholar 

  • Schneiderman N (1983) Behavior, autonomic function and animal models of cardiovascular pathology. In: Dembroski TM, Schmidt TH, Blumchen G (eds) Biobehavioral bases of coronary heart disease. Karger, Basel

    Google Scholar 

  • Schwartz S, Gajdusek C, Shelden S (1981) Vascular wall growth control: the role of endothelium. Arteriosclerosis 1: 107–126

    Article  PubMed  Google Scholar 

  • Shekelle RB, Gale M, Ostfeld AM, Paul O (1983) Hostility, risk of coronary heart disease, and mortality. Psychosom Med 45: 109–114

    PubMed  CAS  Google Scholar 

  • Sokol R, Rolhf FJ (1981) Biometry. Freeman, San Francisco

    Google Scholar 

  • Van Egeren L (1979) Cardiovascular changes during social competition in a mixed-motive game. J Pers Soc Psychol 37: 858–864

    Article  PubMed  Google Scholar 

  • Wagner WD, St Clair RW, Clarkson TB (1978) Angiochemical and tissue changes in Macaca fascicularis fed an atherogenic diet for three years. Exp Mol Pathol 28: 140–153

    Article  PubMed  CAS  Google Scholar 

  • Williams RB (1978) Psychophysiological processes, the coronary–prone behavior pattern, and coronary heart disease. In: Dembroski TM, Weiss SM, Shields JL, Haynes SG, Feinleib M (eds) Coronary–prone behavior. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Williams RB, Haney T, Lee K, Yong Y, Blumenthal J, Whalen R (1980) Type A behavior, hostility and coronary atherosclerosis. Psychosom Med 42: 539–549

    PubMed  Google Scholar 

  • Wright RA, Contrada RJ, Glass DC (1985) Psychophysiologic correlates of Type A behavior. In: Katkin ES, Manuck SB (eds) Advances in behavioral medicine. JAI, Greenwich

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Psychology, Clinical Psychology Center, 604 Engineering Hall, 4015 O’Hara Street, Pittsburgh, PA, 15260, USA

    S. B. Manuck

  2. Arteriosclerosis Research Center, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC, 27109, USA

    T. B. Clarkson

Authors
  1. S. B. Manuck
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  2. J. R. Kaplan
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  3. T. B. Clarkson
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Editor information

Editors and Affiliations

  1. Abteilung Epidemiologie und Sozialmedizin, Medizinische Hochschule Hannover, Konstanty-Gutschow-Straße, 3000, Hannover 61, Germany

    Thomas H. Schmidt

  2. Department of Psychology, University of Maryland, Baltimore County Cantonsville, MD, 21228, USA

    Theodore M. Dembroski

  3. Klinik Roderbirken, 5653, Leichlingen/Rhld. 1, Germany

    Gerhard Blümchen

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© 1986 Springer-Verlag Berlin Heidelberg

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Manuck, S.B., Kaplan, J.R., Clarkson, T.B. (1986). Atherosclerosis, Social Dominance and Cardiovascular Reactivity. In: Schmidt, T.H., Dembroski, T.M., Blümchen, G. (eds) Biological and Psychological Factors in Cardiovascular Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71234-0_28

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  • DOI: https://doi.org/10.1007/978-3-642-71234-0_28

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71236-4

  • Online ISBN: 978-3-642-71234-0

  • eBook Packages: Springer Book Archive

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