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Einfluß von Thiolen auf die subzelluläre Wirkungsvermittlung der organischen Nitrate

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Vasoaktive Substanzen bei Herzinsuffizienz

Zusammenfassung

Organische Nitrate wirken auf subzellulärer Ebene über eine Stimulierung des Enzyms Guanylzyklase (E.C. 4.6.1.2) [1, 9]. Dieses Enzym ist verantwortlich für die Bildung von cGMP (zyklisches Guanosin-3′:5′-monophosphat) aus GTP (Guano-sin-5′-triphosphat). Das gebildete cGMP relaxiert konzentrationsabhängig über noch unbekannte Zwischenschritte die glatte Gefäßmuskulatur und vermittelt so die hämodynamische Wirkung der organischen Nitrate.

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Authors and Affiliations

  1. Pharmakologisches Institut der Universität, Moorenstraße 5, D-4000, Düsseldorf 1, Germany

    H. Schröder

Authors
  1. H. Schröder
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  2. E. Noack
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Editor information

Editors and Affiliations

  1. Zentrum der Inneren Medizin, Abteilung für Kardiologie, Klinikum der Johann-Wolfgang-Goethe Universität, Theodor-Stern-Kai 7, D-6000, Frankfurt, Germany

    Wulf-Dirk Bussmann

  2. Innere Medizin III, Medizinische Universitätsklinik, Hugstetter Str. 55, D-7800, Freiburg i. Br., Germany

    H. Just

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© 1986 Springer-Verlag Berlin Heidelberg

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Schröder, H., Noack, E. (1986). Einfluß von Thiolen auf die subzelluläre Wirkungsvermittlung der organischen Nitrate. In: Bussmann, WD., Just, H. (eds) Vasoaktive Substanzen bei Herzinsuffizienz. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71486-3_6

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  • DOI: https://doi.org/10.1007/978-3-642-71486-3_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-16946-8

  • Online ISBN: 978-3-642-71486-3

  • eBook Packages: Springer Book Archive

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