Abstract
The observation of an enhanced platelet reactivity after infusion of prostacyclin in clinical studies [1] suggests the possibility that the administration of this compound might inhibit the endogenous release of prostacyclin and, consequently, result in hyperactive platelets. In order to explore this possibility, we have studied the effects of acute and chronic administration of Iloprost in the rat, on the release of 6-keto-PGF1α from in vitro perfused aortas.
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Sinzinger H, Silberbauer K, Horsch AK, Gall A (1981) Decreased sensitivity of human plate-lets to PGI2 during long-term intraarterial prostacyclin infusion in patients with peripheral vascular disease — a rebound phenomenon? Prostaglandins 21: 49
Galli C, Petroni A, Socini A, Agradi E, Colombo C, Folco GC, Tremoli E (1981) Platelet- vessel wall interactions: effects of platelets and plasma on the antiaggregatory activity and 6- keto-PGF1α production in isolated perfused aortas. Prostaglandins 22: 703
Salmon JA (1978) A radioimmunoassay for 6-keto-Prostaglandin F1α. Prostaglandins 15: 383
Krause W, Schubert M (1983) Pharmacokinetics and biotransformation of the prostacyclin analogue, ZK 36 374. II. Blood and plasma levels and passage of the blood/brain barrier in the rat. Eur J Drug Metab Pharmacokinet 8: 145
Tremoli E, Socini A, Petroni A, Galli C (1982) Increased platelet aggregability is associated with increased prostacyclin production by vessel walls in hypercholesterolemic rabbits. Prostaglandins 24: 397
Fitzgerald GA, Smith B, Pedersen AK, Brash AR (1984) Increased prostacyclin biosynthesis in patients with severe atherosclerosis and platelet activation. N Engl J Med 310: 1065
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© 1987 Springer-Verlag, Berlin Heidelberg
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Masi, I., Giani, E., Mosconi, C., Galli, C. (1987). Effects of Iloprost Treatment in the Rat on Prostacyclin Release from Isolated Aortas. In: Gryglewski, R.J., Stock, G. (eds) Prostacyclin and Its Stable Analogue Iloprost. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71499-3_16
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DOI: https://doi.org/10.1007/978-3-642-71499-3_16
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-71501-3
Online ISBN: 978-3-642-71499-3
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