Abstract
The c-myb proto-oncogene, which encodes a nuclear DNA binding protein (Boyle 1984, Kempnauer 1984) has been reported to be expressed predominantly in normal tissue and tumor cells of hematopoietic origin (Westin 1982; Gonda 1982). Moreover, for each hematopoietic lineage examined, the steady state levels of c-myb mRNA expression are highest in immature cells. These properties of the c-myb gene and its products are consistent with the idea that c-myb regulates hematopoietic maturation by controlling the expression of other genes. We have begun to examine this hypothesis using B-cell tumor lines.
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References
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© 1986 Springer-Verlag Berlin · Heidelberg
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Bender, T.P., Kuehl, W.M. (1986). Structure and Expression of c-myb Protooncogene mRNA in Murine B-Cells. In: Melchers, F., Potter, M. (eds) Mechanisms in B-Cell Neoplasia. Current Topics in Microbiology and Immunology, vol 132. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71562-4_22
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DOI: https://doi.org/10.1007/978-3-642-71562-4_22
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