Abstract
The survival and development of neurons is regulated by epigenetic factors (for review see Thoenen and Edgar, 1985). For example, the protein, Nerve Growth Factor (NGF), has been demonstrated to play a role in the nervous system: both peripheral sympathetic and sensory neurons derived from the neural crest need NGF for survival during development, and for maintenance during adulthood (see Thoenen and Edgar, 1985). Furthermore, it now seems that NGF plays a trophic role in the maintenance of magnocellular, cholinergic neurons of the central nervous system (Otten et al., 1985). The role of NGF in vivo is also reflected by the necessity for its presence for the survival of NGF-responsive neurons in culture (Thoenen and Edgar, 1985). Recently, it has become apparent that a variety of neurons that do not respond to NGF require other soluble trophic factors if they are to survive in vitro (see Barde et al., 1983). Two putative trophic molecules have been isolated by virtue of their ability to support neuronal survival in culture (Barde et al., 1982; Barbin et al., 1984). The role of these factors in vivo remains to be determined.
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References
Acheson, A., D. Edgar, R. Timpl, and H. Thoenen (1986) Regulation of enzyme synthesis in chromaffin cells by contact with the basement membrane protein, laminin. J. Cell Biol. 102: 151–159.
Adler, R., M. Manthorpe, S.D. Skaper, and S. Varon (1981) Polyornithine neurite promoting factors. Brain Res. 206: 129–144.
Barbin, G., M. Manthorpe, and S. Varon (1984) Purification of the chick eye ciliary neurotrophic factor. J. Neurochem. 43: 1468–1478.
Barde, Y.-A., D. Edgar, and H. Thoenen (1982) Purification of a new neurotrophic factor from mammalian brain. EMBO J. 1: 549–553.
Barde, Y.-A., D. Edgar, and H. Thoenen (1983) New neurotrophic factors. A. Rev. Physiol. 45: 601–612.
Baron-van Evercooren, A., H.K. Kleinman, S. Ohno, P. Marangos, J.P. Schwartz, and M.E. Dubois-Dalcq (1982) Nerve growth factor, laminin, and fibronectin promote neurite growth in human fetal sensory ganglia cultures. J. Neurosci. Res. 8: 179–193.
Collins, F. (1978) Induction of neurite outgrowth by a conditioned medium factor bound to the culture substratum. Proc. Natl. Acad. Sci. (USA) 75: 5210–5213.
Cornbrooks, C.J., D.J. Carey, J.A. McDonald, R. Timpl, and R.P. Bunge (1983) In vivo and in vitro observations on laminin production by Schwann cells. Proc. Natl. Acad. Sci. (USA) 80: 3850–3854.
Davis, G.E., M. Manthorpe, E. Engvall, and S. Varon (1985) Isolation and characterization of rat schwannoma neurite promoting factor: Evidence that the factor contains laminin. J. Neurosci. 5: 2662–2671.
Dohrmann, U., D. Edgar, M. Sendtner, and H. Thoenen (1986) Muscle-derived factors that support survival and promote fiber outgrowth from embryonic chick motor neurons in culture. Dev. Biol., in press.
Dziadek, M., D. Edgar, M. Paulsson, R. Timpl, and R. Fleischmajer (1986) Basement membrane proteins produced by Schwann cells and in Neurofibromatosis. Annals N.Y. Acad. Sci., in press.
Edgar, D. (1985) Nerve growth factor and molecules of the extracellular matrix in neuronal development. J. Cell Sci. Suppl. 3: 107–113.
Edgar, D., and H. Thoenen (1982) Modulation of NGF-induced survival of chick sympathetic neurons. Dev. Brain Res. 5: 89–92.
Edgar, D., R. Timpl, and H. Thoenen (1984) The heparin-binding domain of laminin is responsible for its effects on neurite outgrowth and neuronal survival. EMBO J. 3: 1463–1468.
Ide, C., K. Tohyama, R. Yokota, T. Nitatori, and S. Onodera (1983) Schwann cell basal lamina and nerve regeneration. Brain Res. 288: 61–75.
Lander, A.D., D.K. Fujii, D. Gospodarowicz, and L.F. Reichardt (1982) A heparan sulfate proteoglycan induces rapid neurite outgrowth in vitro. J. Cell Biol. 94: 574–582.
Lander, A.J., D.K. Fujii, D. Gospodarawicz, and L.F. Reichardt (1985) Neurite outgrowth promoting factors in conditioned medium are complexes containing laminin. Proc. Natl. Acad. Sci. (USA) 82: 2183–2187.
Ott, U., E. Odermatt, J. Engel, H. Furthmayr, and R. Timpl (1982) Protease resistance and conformation of laminin. Eur. J. Biochem. 123: 63–72.
Otten, U., G. Weskamp, M. Schlumpf, W. Lichtensteiger, and W.C. Mobley (1985) Effects of antibodies against NGF on developing cholinergic forebrain neurons in rat. Soc. Neurosci. Abst. Vol. 11, Part 1, p. 661.
Rogers, S.L., K.J. Edson, P.C. Letourneau, and S.C. McLoon (1986) Distribution of laminin in the developing peripheral nervous system of the chick. Dev. Biol. 113: 429–435.
Sakashita, S., E. Engvall, and E. Ruoslahti (1980) Basement membrane protein laminin binds to heparin. FEBS Lett. 116: 243–246.
Terranova, V.P., C.N. Rao, T. Kalebic, I.M. Margulies, and L.A. Liotta (1983) Laminin receptor on human breast carcinoma cells. Proc. Natl. Acad. Sci. (USA) 80: 444– 448.
Thoenen, H., and D. Edgar (1985) Neurotrophic factors. Science 229: 238–242.
Timpl, R., H. Rohde, P.G. Robey, S.I. Rennard, S.M. Foidart, and G.R. Martin (1979) Laminin - a glycoprotein from basement membranes. J. Biol. Chem. 254: 9933– 9937.
Von der Mark, K., and U. Kiihl (1985) Laminin and its receptor. Biochim. Biophys. Acta 823: 147–160.
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© 1988 Springer-Verlag Berlin
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Edgar, D., Nurcombe, V., Dohrmann, U. (1988). Substrates Influencing the Survival and Development of Neural Cells in Vitro. In: Wolff, J.R., Sievers, J., Berry, M. (eds) Mesenchymal-Epithelial Interactions in Neural Development. NATO ASI Series, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71837-3_26
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DOI: https://doi.org/10.1007/978-3-642-71837-3_26
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