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Drug-Induced Alteration of Ganglioside Biosynthesis

  • Conference paper
Gangliosides and Modulation of Neuronal Functions

Part of the book series: NATO ASI Series ((ASIH,volume 7))

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Abstract

The glycosphingolipid biosynthesis may be regulated at two major points; one at the genetic level, where the carbohydrate series and possibly the substitution by carbohydrate side chains is decided. Second to this, the total amount and the component ratio distribution may be epigenetically regulated. The latter mechanism may include glycolipid changes during the cell cycle (2,3,4,5,6) or upon cell to cell contact (7,8,9). Besides this, a number of drugs, among them lectins, differentiation inducers and opiates, apparently interfere with this epigenetic regulation.

Short hand designations for gangliosides are as defined earlier (1), The neutral oligosaccharide back-bone is given as an index and the number of sialic acid residues by an Arabic numeral. Positional isomers are specified by adding a, b, c.

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Abbreviations

CMH:

ceramide monohexoside

CDH:

ceramide dihexoside

CTH:

ceramide trihexoside

CTetH:

ceramide tetrahexoside

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Author information

Authors and Affiliations

  1. Physiologisch-Chemisches Institut und Med. Zentrum für Hygiene und Mikrobiologie Abteilung Virologie, Philipps-Universität, 3550, Marburg, Germany

    H. Wiegandt

  2. Med. Zentrum für Hygiene und Mikrobiologie Abteilung Virologie, Philipps-Universität, 3550, Marburg, Germany

    K. Radsak

Authors
  1. H. Wiegandt
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  2. K. Radsak
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Editor information

Editors and Affiliations

  1. Zoological Institute, University of Stuttgart-Hohenheim, Garbenstr. 30, 7000, Stuttgart 70, Germany

    Hinrich Rahmann

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© 1987 Springer-Verlag Berlin Heidelberg

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Wiegandt, H., Radsak, K. (1987). Drug-Induced Alteration of Ganglioside Biosynthesis. In: Rahmann, H. (eds) Gangliosides and Modulation of Neuronal Functions. NATO ASI Series, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71932-5_24

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  • DOI: https://doi.org/10.1007/978-3-642-71932-5_24

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71934-9

  • Online ISBN: 978-3-642-71932-5

  • eBook Packages: Springer Book Archive

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