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Familial and Hereditary Non-polyposis Colorectal Cancer: Issues Relevant for Surgical Practice

  • Conference paper
Rectal Cancer

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 146))

  • 132 Accesses

Abstract

About 15% of patients with colorectal cancer report a family history of this disease. An estimated 1%–5% of patients have hereditary non-polyposis colorectal cancer (HNPCC). Recently, DNA mismatch repair genes associated with this syndrome were identified. For about 50% of families in which HNPCC occurs, DNA-based diagnosis and presymptomatic DNA testing are now feasible. Diagnosis of a hereditary tumour syndrome is relevant for both the patient with cancer and his or her close relatives. The complexities of family studies warrant the forming of a multidisciplinary team which may choose to work within a specialized cancer family clinic.

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Author information

Authors and Affiliations

  1. Department of Clinical Genetics, University Hospital Vrije Universiteit, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands

    F. H. Menko

  2. Department of Human Genetics, Medical Genetics Center, Sylvius Laboratories, Leiden University, Leiden, The Netherlands

    J. T. Wijnen & P. Meera Khan

  3. Foundation for the Detection of Hereditary Tumours, Leiden, The Netherlands

    H. F. A. Vasen

  4. Department of Medical Genetics, Faculty of Medicine, University of Groningen, Groningen, The Netherlands

    R. H. Sijmons

Authors
  1. F. H. Menko
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  2. J. T. Wijnen
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  3. H. F. A. Vasen
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  4. R. H. Sijmons
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  5. P. Meera Khan
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Editor information

Editors and Affiliations

  1. Klinik für Chirurgie und Chirurgische Onkologie, Universitätsklinikum Charité, Robert-Rössle-Klinik, Lindenberger Weg 80, D-13125, Berlin, Germany

    Peter M. Schlag

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© 1998 Springer-Verlag Berlin · Heidelberg

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Menko, F.H., Wijnen, J.T., Vasen, H.F.A., Sijmons, R.H., Khan, P.M. (1998). Familial and Hereditary Non-polyposis Colorectal Cancer: Issues Relevant for Surgical Practice. In: Schlag, P.M. (eds) Rectal Cancer. Recent Results in Cancer Research, vol 146. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71967-7_2

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  • DOI: https://doi.org/10.1007/978-3-642-71967-7_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71969-1

  • Online ISBN: 978-3-642-71967-7

  • eBook Packages: Springer Book Archive

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