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VLA-4-Mediated Signaling

  • Chapter
Leukocyte Integrins in the Immune System and Malignant Disease

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 231))

Abstract

The VLA (very late antigens) constitute the β1 subfamily of integrin adhesion receptors defined by at least nine α-chains that share a noncovalently linked common β-chain, termed β1 (CD29) (Hynes 1992; Schwartz 1993). The VLA mainly function as cell surface receptors mediating cell-to-cell and cell-to-extracellular matrix (ECM) adhesive interactions. They constitute a major class of adhesive receptors expressed by T cells. On resting CD4+ T cells, the VLA/CD29 antigens are preferentially expressed on the CD45RO+ CD45RA− helper/inducer (memory) subset (Morimoto et al. 1985). VLA molecules are thought to play a major role in the interaction between these helper cells and the surrounding ECM or aid their migration into tissues (Shimizu and Shaw 1991). Apart from a role in cell adhesion, recent studies have clearly shown the VLA receptors to transduce signals in a wide variety of cells, including T lymphocytes (Schwartz et al. 1991; Shattil and Brugge 1991; Sultan et al. 1991). For example, several laboratories, including ours, have shown that the binding of T cells with ECM through VLA- β1-integrins provides costimulatory signals for T cell proliferation (Matsuyama et al. 1989; Nojima et al. 1990; Yamada et al. 1991a, b; Ennis et al. 1993). VLA-β1-integrins are also reported to be involved in T or B cell differentiation through interaction with fibronectin (FN), expressed on stromal cells in thymus or bone marrow, respectively (Salomon et al. 1994; Williams et al. 1991).

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Authors and Affiliations

  1. Division of Tumor Immunology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts, 02115, USA

    C. Morimoto, S. Iwata & K. Tachibana

  2. Department of Clinical Immunology and AIDS Research Center, Institute of Medical Science, University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo, 108, Japan

    C. Morimoto

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  1. C. Morimoto
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  2. S. Iwata
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  3. K. Tachibana
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Editors and Affiliations

  1. Institute of Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, Trogerstr. 9, D-81675, Munich, Germany

    Bernhard Holzmann M.D.  & Hermann Wagner M.D., Ph.D.  & 

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© 1998 Springer-Verlag Berlin Heidelberg

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Morimoto, C., Iwata, S., Tachibana, K. (1998). VLA-4-Mediated Signaling. In: Holzmann, B., Wagner, H. (eds) Leukocyte Integrins in the Immune System and Malignant Disease. Current Topics in Microbiology and Immunology, vol 231. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71987-5_1

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  • DOI: https://doi.org/10.1007/978-3-642-71987-5_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71989-9

  • Online ISBN: 978-3-642-71987-5

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