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Transplacental Carcinogenesis, Mouse, Rat, Hamster

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Genital System

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

Abstract

In spite of the statement made in older textbooks that the placenta forms a protective barrier for the embryo and fetus, today we can state with certainty that most chemicals, many vi- mses, and even some blood cells, are transferred through the placenta and may cause disease in the offspring. Cancer can also be induced by compounds transferred across the placenta during the prenatal period.

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References

  • Alexandrov VA (1983) Role of the matemal organism in transplacental carcinogenesis. I ARC Sci Publ 51:65–79

    CAS  Google Scholar 

  • Althoff J, Pour P, Grandjean C, Marsh S (1977) Transplacental effects of nitrosamines in Syrian hamsters. III. Dimethyl- and dipropylnitrosamine. Z Krebsforsch Klin Onkol 90:79–86

    Article  CAS  Google Scholar 

  • Antonioli DA, Rosen S, Burke L, Donahue V (1979) Glandular dysplasia in diethylstilbestrol- associated vaginal adenosis. Am J Clin Pathol 71: 715–721

    PubMed  CAS  Google Scholar 

  • Barber HRK, Sommers SC (1974) Vaginal adenosis, dysplasia and clear cell adenocarcinoma after diethylstilbestrol treatment in pregnancy. Obstet Gynecol 43: 645–652

    PubMed  CAS  Google Scholar 

  • Druckrey H, Ivankovic S, Preussmann R (1966) Teratogenic and carcinogenic effects in the offspring after single injection of ethylnitrosourea to pregnant rats. Nature 210:1378–1379

    Article  PubMed  CAS  Google Scholar 

  • Forsberg JG (1973) Cervicovaginal epithelium: its origin and development. Am J Obstet Gynecol 115:1025–1043

    PubMed  CAS  Google Scholar 

  • Forsberg JG, Kalland T (1981) Neonatal estrogen treatment and epithelial abnormalities in the cervicovaginal epithelium of adult mice. Cancer Res 41:721–734

    PubMed  CAS  Google Scholar 

  • Goth R, Rajewsky MF (1972) Ethylation of nucleic acids by ethylnitrosourea-l-14C in the fetal and adult rat. Cancer Res 32:1501–1505

    PubMed  CAS  Google Scholar 

  • Herbst AL, Scully RE (1970) Adenocarcinoma of the vagina in adolescence. A report of 7 cases including 6 clear- cell carcinomas. Cancer 25: 745–757

    Article  PubMed  CAS  Google Scholar 

  • Herbst AL, Ulfelder H, Poskanzer DC (1971) Adenocarcinoma of the vagina. Association of matemal stilbestrol therapy with tumor appearance in young women. N EnglJMed 284:878–881

    Article  PubMed  CAS  Google Scholar 

  • Hill EC (1973) Clear cell carcinoma of the cervix and vagina in young women. A report on 6 cases with association of matemal silbestrol therapy and adenosis of the vagina. Am J Obstet Gynecol 116:470–484

    PubMed  CAS  Google Scholar 

  • Larsen CD (1947) Pulmonary tumor induction by transplacental exposure to urethane. JNCI 8: 63–69

    CAS  Google Scholar 

  • Law LW (1940) The production of tumors by injection of a carcinogen into the amniotic fluid of mice. Science 91: 96–97

    Article  PubMed  CAS  Google Scholar 

  • McLachlan JA, Newbold RR, Bullock BC (1980) Long- term effects on the female mouse genital tract associated with prenatal exposure to diethylstilbestrol. Cancer Res 40:3988–3999

    PubMed  CAS  Google Scholar 

  • Menon MM, Bhide SV (1983) Perinatal carcinogenicity of isoniazid (INH) in Swiss mice. J Cancer Res Clin Oncol 105:258–261

    Article  PubMed  CAS  Google Scholar 

  • Miller EW, Pybus FC (1955) The incidence of spontaneous and induced forestomach tumours in mice of two inbred strains and their reciprocal hybrids. Br J Cancer 9: 142–162

    Article  PubMed  CAS  Google Scholar 

  • Miller RW (1973) Prenatal origins of cancer in man: epidemiological evidence. lARC Sci Publ 4:175–180

    Google Scholar 

  • Mohr U, Althoff J (1964) Mögliche diaplacentar-carcino- gene Wirkung von Diäthylnitrosamin beim Goldhamster. Naturwissenschaften 51: 515

    Article  CAS  Google Scholar 

  • Mohr U, Althoff J, Authaler A (1966) Diaplacental effect of the carcinogen diethylnitrosamine in the golden hamster. Cancer Res 26: 2349–2352

    PubMed  CAS  Google Scholar 

  • Mohr U, Emura M, Richter-Reichhelm H-B (1980) Transplacental carcinogenesis. Invest Cell Pathol 3:209–229

    PubMed  CAS  Google Scholar 

  • Newbold RR, McLachlan JA (1982) Vaginal adenosis and adenocarcinoma in mice exposed prenatally or neonatally to diethylstilbe ilbestrol. Cancer Res 42: 2003–2011

    PubMed  CAS  Google Scholar 

  • Nomura T (1975) Transmission of tumors and malformations to the next generation of mice subsequent to urethan treatment. Cancer Res 35: 264–266

    PubMed  CAS  Google Scholar 

  • Ogawa K, Yokokawa K, Tomoyori T, Narasaki M (1983) Initiation of focal hyperplastic hepatic lesions by transplacental administration of ethylnitrosourea in rats of Fl generation, and no transmission of the effect to F2 and F3 generation. Int J Cancer 31: 775–777

    Article  PubMed  CAS  Google Scholar 

  • Pelkonen O (1977) Transplacental transfer of foreign compounds and their metabolism by the foetus. Prog Drug Metab 2:119–161

    CAS  Google Scholar 

  • Plapinger L, Bem HA (1979) Adenosis-like lesions and other cervicovaginal abnormalities in mice treated perinatally with estrogen. JNCI 63: 507–518

    PubMed  CAS  Google Scholar 

  • Rao AR (1982) Inhibitory action of BHA on carcinogenesis in Fl and F2 descendants of mice exposed to DMBA during pregnancy. Int J Cancer 30:121–124

    Article  PubMed  CAS  Google Scholar 

  • Reznik-Schüller HM, Hague BF Jr (1981) Autoradiography in fetal Syrian golden hamsters treated with tritiated diethylnitrosamine. JNCI 66: 773–777

    PubMed  Google Scholar 

  • Rohrbom G (1983) Correlation between mutagenesis and carcinogenesis. lARC Sci Publ 4:168–174

    Google Scholar 

  • Rustia M (1979) Role of hormone imbalance in transplacental carcinogenesis induced in Syrian golden hamsters by sex hormones. Natl Cancer Inst Monogr 51:77–87

    PubMed  CAS  Google Scholar 

  • Schneider P (1981) Multigenerationsstudie zur transpla- zentaren Wirksamkeit von 7, 12-Dimethylbenz(a)anthra- zen bei C57BL/6-Mausen. Dissertation, University of Hannover

    Google Scholar 

  • Scully RE, Robboy S, Welch WR (1978) Pathology and pathogenesis of diethylstilbestrol-related disorders of the female genital tract. In: Herbst AL (ed) Intrauterine exposure to diethylstilbestrol in the human. American College of Obstetricians Gynecologists, Chicago, pp8–22

    Google Scholar 

  • Shah HC, McLachlan JA (1976) The fate of diethylstilbestrol in the pregnant mouse. J Pharmacol Exp Ther 197: 687–696

    PubMed  CAS  Google Scholar 

  • Shay H, Gmenstein M, Weinberger M (1952) Tumor incidence in Fl and F2 generations derived from female rats fed methylcholanthrene by stomach tube prior to conception. Cancer Res 12: 296

    Google Scholar 

  • Smith WE, Rous P (1948) The neoplastic potentialities of mouse embryo tissues. IV. Lung adenomas in baby mice as result of prenatal exposure to urethan. J Exp Med 88: 529–554

    Article  PubMed  CAS  Google Scholar 

  • Spatz M, Laquer GL (1967) Transplacental induction of tumors in Sprague-Dawley rats with cmde cycad material. JNCI 38:233–245

    PubMed  CAS  Google Scholar 

  • Tanaka T (1973) Transplacental induction of tumours and malformations in rats treated with some chemical carcinogens. lARC Sci Publ 4:100–111

    Google Scholar 

  • Tomatis L (1979) Prenatal exposure to chemical carcinogens and its effect on subsequent generations. Natl Cancer Inst Monogr 51:159–184

    PubMed  Google Scholar 

  • Tomatis L, Goodall CM (1969) The occurrence of tumours in Fl, F2 and F3 descendants of pregnant mice injected with 7, 12-dimethylbenz(a)anthracene. Int J Cancer 4: 219–225

    Article  PubMed  CAS  Google Scholar 

  • Tomatis L, Tumsov V, Guibbert D, Duperray B, Mala-veille C, Pacheco H (1971) Transplacental carcinogenic effect of 3-methylcholanthrene in mice and its quantitation in fetal tissues. JNCI 47: 645–651

    PubMed  CAS  Google Scholar 

  • Walker BE (1984) Tumors of female offspring of mice exposed prenatally to diethylstilbestrol. JNCI 73:133–140

    PubMed  CAS  Google Scholar 

  • Wiestler OD, Kleihues P, Rice JM, Ivankovic S (1984) DNA methylation in matemal, fetal and neonatal rat tissues following perinatal administration of procarbazine. J Cancer Res Clin Oncol 108: 56–59

    Article  PubMed  CAS  Google Scholar 

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© 1987 Springer-Verlag Berlin Heidelberg

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Mohr, U., Emura, M., Michaela, Riebe, M., Ernst, H. (1987). Transplacental Carcinogenesis, Mouse, Rat, Hamster. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Genital System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72550-0_24

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  • DOI: https://doi.org/10.1007/978-3-642-72550-0_24

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-72552-4

  • Online ISBN: 978-3-642-72550-0

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