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Purging of Bone Marrow with a Cocktail of Monoclonal Antibodies (VIB-pool) for Autologous Transplantation

  • Conference paper
Modern Trends in Human Leukemia VII

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 31))

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Abstract

Children with relapsed common acute lymphoblastic leukemia (ALL), B-non-Hodgkin lymphoma (B-NHL), and B-acute lymphocytic leukemia (B-ALL) have a very poor prognosis. If there is no HLA-identical donor, the patient should be considered for autologous bone marrow transplantation. Collected autologous marrow should be cleansed of contaminating tumor cells without destroying hemopoietic stem cells. We report here the results of our investigations with a cocktail of three monoclonal antibodies (VIL-A 1, VIB-C 5, and VIB-E 3 — the VIB pool — kindly given to us by Dr. Knapp of Vienna) concerning in vitro cytotoxicity against ALL blast cells and leukemic cells lines, lytic capacity with rabbit and human complement, and stem cell toxicity, together with our findings concerning the ex vivo purging of the marrow of four children.

This investigation was supported by the Internationale Gesellschaft für Chemo- und Immunotherapie, Vienna

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References

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Authors and Affiliations

  1. Department of Pediatrics, University Hospital of Jena, GDR

    F. Zintl, B. Reiners, H. Thränhardt, J. Hermann, D. Fuchs & J. Prager

Authors
  1. F. Zintl
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  2. B. Reiners
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  3. H. Thränhardt
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  4. J. Hermann
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  5. D. Fuchs
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  6. J. Prager
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Editor information

Editors and Affiliations

  1. Medizinische Klinik, Abteilung für klinische Chemie, Universitäts-Krankenhaus Eppendorf, Martinistraße 52, 2000, Hamburg 20, Germany

    Rolf Neth

  2. Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD, 20205, USA

    Robert C. Gallo

  3. Institute of Cancer Research, Chester Beatty Laboratories, Leukemia Research Fund Centre, Fulham Road, London, SW3 6JB, UK

    Melvyn F. Greaves

  4. Abteilung für Hämatologie und Onkologie, Universitäts-Kinderklinik, Martinistraße 52, 2000, Hamburg 20, Germany

    Hartmut Kabisch

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© 1987 Springer-Verlag Berlin Heidelberg

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Zintl, F., Reiners, B., Thränhardt, H., Hermann, J., Fuchs, D., Prager, J. (1987). Purging of Bone Marrow with a Cocktail of Monoclonal Antibodies (VIB-pool) for Autologous Transplantation. In: Neth, R., Gallo, R.C., Greaves, M.F., Kabisch, H. (eds) Modern Trends in Human Leukemia VII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 31. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72624-8_19

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  • DOI: https://doi.org/10.1007/978-3-642-72624-8_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-17754-8

  • Online ISBN: 978-3-642-72624-8

  • eBook Packages: Springer Book Archive

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