Abstract
Cytosine arabinoside (Ara-C) is one of the most effective agents in the treatment of acute myelogenous leukemia (AML). Recently, low-dose Ara-C therapy has been the subject of topical interest in view of its differentiation-inducing effect on leukemic blast cells. Many patients, however, develop severe aplasia with low-dose Ara-C therapy [1, 6, 10, 11]. The aim of our study was to obtain some information about causes of this aplasia, i.e., to determine whether the lesion is primarily in the hemopoietic stem cells or whether there is any additional damage done to stromal elements.
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© 1987 Springer-Verlag Berlin Heidelberg
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Elstner, E., Goldschmidt, H., Wächter, M., Ihle, R. (1987). Sensitivity of Stromal Elements from Human Bone Marrow Cells to Cytosine Arabinoside In Vitro. In: Neth, R., Gallo, R.C., Greaves, M.F., Kabisch, H. (eds) Modern Trends in Human Leukemia VII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 31. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72624-8_39
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DOI: https://doi.org/10.1007/978-3-642-72624-8_39
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