Abstract
A field theory [1] models malignancy as a state “added” to, and capable of interacting with, other normal states composing the field associated with any living cell. The theory may be downscaled from the (multi) cellular to the level of topologically disordered motions of chromatin and DNA strings occurring before or at interphase when chromatids are iteratively dilated in cells mitotically driven by a potential from special “source” cells. Clonal development of tumors might result from the extremely low efficiency with which the driving potential activates its corresponding gene(s) P in one (or exceedingly few) source-dependent cell. Most normal cells are assumed to have gene P “curled up” in some nonexpressed configuration in a segment j (say) within a lattice or plaquette unfolded from crumpled preimages during chromatid decondensation [11–13].
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References
Matioli GT (1982) Annotation on stem cells and differentiation fields. Differentiation 21:139
De-Gennes P (1979) Scaling concepts in polymer physics. Cornell University Press, Ithaca
Suzuki M (1983) Brownian motion with geometrical restrictions. In: Yonezawa F, Ninomiya T (eds) Topological disorder in condensed matter. Springer, Berlin Heidelberg New York Tokyo (Springer series in solid-state sciences, vol 46)
Coniglio A, Stanley E (1984) Screening of deeply invaginated clusters and the critical behavior of the random superconducting network. Phys Rev Lett 52:1068
Mandelbrot BB (1983) The fractal geometry of nature. Freeman, San Francisco
Abraham RH (1985) Dynamics, vol 0–4. Sci Front Press
Percival I, Richards D (1985) Introduction to dynamics. Cambridge University Press, Cambridge
Krylov NS (1979) Raboty po obosnovaniiu statisticheskoi fiziki. Princeton University Press, Princeton
Lichtenberg AJ, Lieberman MA (1982) Regular and stochastic motion. Springer, Berlin Heidelberg New York
Zaslavsky GM (1985) Chaos in dynamic systems. Harwood, London
Rivier N (1987) Continuous random networks. From graphs to glasses. Adv Phys 36:95
Kantor Y, Kardar M, Nelson DR (1987) Tethered surfaces: Static and dynamics. Phys Rev A 35:3056
Coniglio A, Majid I, Stanley HE (1987) Conformation of a polymer chain at the “theta” point: Connection to the external perimeter of a percolation cluster. Phys Rev B 35:3617
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© 1987 Springer-Verlag Berlin Heidelberg
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Matioli, G.T. (1987). Cancer Clonality and Field Theory. In: Neth, R., Gallo, R.C., Greaves, M.F., Kabisch, H. (eds) Modern Trends in Human Leukemia VII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 31. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72624-8_61
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DOI: https://doi.org/10.1007/978-3-642-72624-8_61
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