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The Regulation of T-Cell Proliferation: A Role for Protein Kinase C

  • Conference paper
Modern Trends in Human Leukemia VII

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 31))

  • 37 Accesses

Abstract

T-lymphocyte proliferation is regulated by the T-cell growth factor interleukin 2 (IL-2) which exerts its biological effects through an interaction with high-affinity specific IL-2 receptors [1–3]. Quiescent T-lymphocytes neither produce IL-2 nor express IL-2 receptors [2, 4]. However, following immune stimulation there is transcriptional activation of both the IL-2 and IL-2 receptor genes which results in IL-2 synthesis and IL-2 receptor expression [5–7]. T-cell proliferation can then proceed via an autocrine pathway in which the population secretes and responds to its own growth factor.

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References

  1. Smith KA (1980) Immun Rev 41:337

    Article  Google Scholar 

  2. Robb R, Munck A, Smith KA (1981) J Exp Med 154:1455

    Article  PubMed  CAS  Google Scholar 

  3. Cantrell DA, Smith KA (1984) Science 224:1313

    Article  Google Scholar 

  4. Cantrell DA, Smith KA (1983) J Exp Med 158:1895

    Article  PubMed  CAS  Google Scholar 

  5. Efrat S, Pilo S, Kaempfer R (1982) Nature 297:236

    Article  PubMed  CAS  Google Scholar 

  6. Leonard WJ, Kronke M, Peffer NJ, Depper JM, Greene WC (1985) Proc Natl Acad Sci USA 82:6281

    Article  PubMed  CAS  Google Scholar 

  7. Grabstein K, Dower S, Gillis S, Urdal D, Larsen AJ (1986) Immunol 136:4503

    CAS  Google Scholar 

  8. Meuer SC, Fitzgerald KA, Hussey RE, Hodgdon JC, Schlossman SF, Reinherz EL (1983) J Exp Med 157:707

    Article  Google Scholar 

  9. Acuto O, Hussey RE, Fitzgerald KA, Protentis S, Meuer SC, Schlossman SF, Reinherz EL (1983) Cell 34:717

    Article  PubMed  CAS  Google Scholar 

  10. Meuer SC, Cooper DA, Hodgdon JC, Hussey RE, Fitzgerald KA, Schlossman SF, Reinherz EL (1983) Science 222:1239

    Article  PubMed  CAS  Google Scholar 

  11. Meuer SC, Acuto O, Hussey RE, Hodgdon JC, Fitzgerald KA, Schlossman SF, Reinherz EL (1983) Nature 303:808

    Article  PubMed  CAS  Google Scholar 

  12. Brenner MB, Trowbridge JS, Strominger JL (1985) Cell 40:183

    Article  PubMed  CAS  Google Scholar 

  13. Kannelopoulus JM, Wigglesworth NM, Owen MJ, Crumpton MJ (1983) Embo J 2:1807

    Google Scholar 

  14. Borst J, Alexander S, Elder J, Terhorst C (1983) J Biol Chem 258:5135

    PubMed  CAS  Google Scholar 

  15. Oettgen HC, Terhorst C, Cantley LC, Roscoff PM (1985) Cell 40:583

    Article  PubMed  CAS  Google Scholar 

  16. Roscoff PM, Cantley LW (1983) J Biol Chem 260:14053

    Google Scholar 

  17. Imboden JB, Stobo JO (1985) J Exp Med 161:446

    Article  PubMed  CAS  Google Scholar 

  18. Berridge MJ (1984) Biochem J 220:345

    PubMed  CAS  Google Scholar 

  19. Truneh A, Albert F, Golstein P, Schmitt Verhulot (1985) Nature 313:318

    Article  PubMed  CAS  Google Scholar 

  20. Van Wauve JP, De Mey JR, Goosens JG (1980) J Immunol 124:2708

    Google Scholar 

  21. Burns GF, Boyd AW, Beverley PCL (1982) J Immunol 129:1451

    PubMed  CAS  Google Scholar 

  22. Reinherz EL, Meuer SC, Fitzgerald KA, Hussey RE, Levine H, Schlossman S (1982) Cell 30:735

    Article  PubMed  CAS  Google Scholar 

  23. Weiss A, Wiskocil RL, Stobo JD (1984) J Immunol 133:123

    PubMed  CAS  Google Scholar 

  24. Ando I, Hariri G, Wallace D, Beverley P (1983) Euro J Immunol 15:196

    Article  Google Scholar 

  25. Delia D, Greaves MF, Newman M, Sutherland DR, Minowada J, Kung P, Goldstein G (1982) Int J Cancer 29:23

    Article  PubMed  CAS  Google Scholar 

  26. Cantrell DA, Davies AA, Crumpton MJ (1985) Proc Natl Acad Sci USA 82:8158

    Article  PubMed  CAS  Google Scholar 

  27. Davies AA, Cantrell DA, Crumpton MJ (1985) Biosciences 5:867

    CAS  Google Scholar 

  28. Sibley DR, Strasser RH, Caron MG, Lefkowitz RJ (1985) J Biol Chem 260:3883

    PubMed  CAS  Google Scholar 

  29. Huganir RL, Delcour AH, Greengard P, Hess G (1986) Nature 321:774

    Article  PubMed  CAS  Google Scholar 

  30. Shoyab M, Daharao JE, Todaro GT (1979) Nature (London) 279:387

    Article  CAS  Google Scholar 

  31. Cochet C, Gill GN, Meisenhelder J, Cooper JA, Hunter T (1984) J Biol Chem 259:2553

    PubMed  CAS  Google Scholar 

  32. Iwashita S, Fox CF (1984) J Biol Chem 259:2559

    PubMed  CAS  Google Scholar 

  33. Davis RJ, Czech MP (1985) Proc Natl Acad Sci USA 82:1974

    Article  PubMed  CAS  Google Scholar 

  34. Parker PJ, Coussens L, Totty N, Rhee L, Young S, Chen E, Stabel S, Waterfield MD, Ullrich A (1986) Science 233:853

    Article  PubMed  CAS  Google Scholar 

  35. Coussens L, Parker PJ, Rhee L, Yang-Feng TL, Chen E, Waterfield MD, Francke U, Ullrich A (1986) Science 233:859

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Cell Surface Biochemistry, Imperial Cancer Research Laboratories, Lincoln’s Inn Fields, London, UK

    D. A. Cantrell, A. A. Davies, W. Verbi & M. J. Crumpton

Authors
  1. D. A. Cantrell
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  2. A. A. Davies
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  3. W. Verbi
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  4. M. J. Crumpton
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Editor information

Editors and Affiliations

  1. Medizinische Klinik, Abteilung für klinische Chemie, Universitäts-Krankenhaus Eppendorf, Martinistraße 52, 2000, Hamburg 20, Germany

    Rolf Neth

  2. Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD, 20205, USA

    Robert C. Gallo

  3. Institute of Cancer Research, Chester Beatty Laboratories, Leukemia Research Fund Centre, Fulham Road, London, SW3 6JB, UK

    Melvyn F. Greaves

  4. Abteilung für Hämatologie und Onkologie, Universitäts-Kinderklinik, Martinistraße 52, 2000, Hamburg 20, Germany

    Hartmut Kabisch

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© 1987 Springer-Verlag Berlin Heidelberg

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Cantrell, D.A., Davies, A.A., Verbi, W., Crumpton, M.J. (1987). The Regulation of T-Cell Proliferation: A Role for Protein Kinase C. In: Neth, R., Gallo, R.C., Greaves, M.F., Kabisch, H. (eds) Modern Trends in Human Leukemia VII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 31. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72624-8_71

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  • DOI: https://doi.org/10.1007/978-3-642-72624-8_71

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-17754-8

  • Online ISBN: 978-3-642-72624-8

  • eBook Packages: Springer Book Archive

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