Zusammenfassung
Natürliche und synthetische Retinoide greifen an zahlreichen Punkten in das Immunsystem ein: Die humorale und celluläre Immunantwort kann durch Retinoide verändert werden, die Interferonsynthese wird durch Retinoide beeinflußt, Granulocyten und Entzündungsmediatoren werden durch Retinoide moduliert. Die vielfältigen Angriffsmöglichkeiten der Retinoide im Immunsystem erschweren die Übertragung experimentell gewonnener Daten auf eine Therapie immunologisch bedingter Dermatosen. Allerdings können bereits heute bestimmte entzündliche Krankheitsbilder erfolgreich mit Retinoiden behandelt werden.
Unser Wissen über die Beeinflussung immunologischer Vorgänge durch Retmoide ist noch fragmentarisch und inkomplett. Die vorliegende Arbeit soll deshalb einen Überblick über die physiologischen und pharmakologischen Wirkungen natürlicher und synthetischer Retinoide auf die Immunantwort zum gegenwärtigen Zeitpunkt geben.
Summary
Natural and synthetic retinoids have marked effects on the immune system: retinoids change humoral and cell-mediated immunity, retinoic acid inhibits production of interferon, retinoids modulate polymor- phonuclear granulocytes and mediators of inflammation. The multiple retinoid actions on the immune system render more difficult to transfer experimental data to therapy of immunological dermatoses. But the use of retinoids in the treatment of a variety of skin disorders in which inflammation is a significant component is now successfull.
Our knowledge about immunological effects of retinoids is still quite fragmentary and rather incomplete. An overview of physiological and pharmacological mechanisms of natural and synthetic retinoids on the immune system is given in the present article.
Preview
Unable to display preview. Download preview PDF.
Literaturverzeichnis
Abb, J, Abb, H, Deinhardt, F.: Effect of retinoic acid on the spontaneous and interferon-induced activity of human natural killer cells. Int. J. Cancer 30, 307–310 (1982).
Abb, J, Abb, H, Deinhardt, P: Retinoic acid suppression of human leukocyte interferon production. Immunopharmacology 4, 303–310 (1982).
Abb, J, Deinhardt, P: Effects of retinoic acid on the human lymphocyte response to mitogens. Exp. Cell Biol. 48, 169–179 (1980).
Abb, J, Deinhardt, R: Retinoid-induced growth inhibition of herpes virus-transformed marmoset lymphoblastoid cell lines. Oncology 38, 346 (1981).
Bang, B G, Bang, F B, Foard, M A.: Lymphocyte depression induced in chickens on diets deficient in vitamin A and other components. Amer. J. Path. 68, 147–162 (1972).
Bang, G B, Foard, M A, Bang, P B.: The effect of vitamin A deficiency and Newcastle disease on lymphoid cell systems in chickens. Proc. Soc. exp. Biol. 143, 1140–1146 (1973).
Barnett, J B.: Immunopotentation of the IgE antibody response by 13-cis-retinoic acid. Int. Arch. Allergy 67, 287–290 (1982).
Barnett, J B, Bryant, R L: Adjuvant and immunosuppressive effects of retinol and Tween-80 on IgG production in mice. Int. Arch. Allergy 63, 145–152 (1980).
Baron, S, Kleyn, K M, Russell, J K, Blalock, J E.: Retinoic acid: enhancement of a tumor and inhibition of interferon’s antitumor action. J. nat. Cancer Inst. 67, 95–97 (1981).
Bauer, R, Gollnick, H. (eds.): Retinoide in der Praxis. Grosse Verlag, Berlin (1984).
Bauer, R, Gollnick, H, Brand, G, Orfanos, C E.: 13-cis-retinoic acid modulates the immune response of human blood lymphocytes to Con A and PWM in vitro. Arch. derm. Res. 275, 270 (1983).
Bauer, R, Orfanos, C E.: Influence of retinoid on human blood cells in vitro. TMMP-retinoid inhibits the mitogenic properties of lectins and modulates the lymphocytic response. In: Orfanos, C E, Braun-Falco, O, Farber, E M. (eds.): Retinoids. Advances in basic research and therapy, pp 153–160(1981).
Bauer, R, Orfanos, C E.: Trimethylmethoxyphenyl retinoic acid (Ro 10-1670) inhibits mitogen induced DNA-synthesis in peripheral blood lymphocytes in vitro. Brit. J. Derm. 105, 19–24 (1981).
Bauer, R, Orfanos, C E.: Contemporary aspects of lupus erythematosus and its subsets. In: Rook, A, Maibach, H. (eds.): Recent advances in dermatology, pp 213–236 (1983).
Bauer, R, Orfanos, C E.: Effects of synthetic retinoids on human peripheral blood lymphocytes and polymorphonuclears in vitro. In: Cuncliff, W J, Miller, A J. (eds.): Retinoid therapy, pp 101–118 (1983).
Bauer, R, Schütz, R, Orfanos, C E.: Granulocyten-Migration in vitro bei Psoriasis-Patienten unter aromatischem Retinoid. Z. Hautkr. 57, 1247–1254 (1982).
Bauer, R, Schütz, R, Orfanos, C E.: Impaired motility and random migration of vital polymorphonuclears in vitro after therapy with oral aromatic retinoid in psoriasis. Int. J. Derm. 23, 72–77 (1984).
Bauer, R, Stadler, R, Brand, G, Orfanos, C E.: In-vitro and in-vivo-Effekte eines neuen synthetischen Retinoids (Arotinoid). Hautarzt 34, Suppl. VI, 270–272 (1983).
Bauer, R, Stadler, R, Immel, C, Orfanos, C E.: Acantholyse und eosinophile Spongiose: Pemphigus herpetiformis. Hautarzt 34, 13–17 (1983).
Bauer, R, Stadler, R, Orfanos, C E.: Cutaner Erythematodes: erste Erfahrungen mit oraler Retino-id-Therapie. Z. Hautkr. 57, 463–464 (1982).
Bauer, R, Stadler, R, Gollnick, H.: Cutan-disseminierter LE: Therapie mit aromatischem Retinoid. Hautarzt 34, Suppl. VI, 38–39 (1983).
Blalock, J E, Gifford, G E.: Inhibition of interferon action by vitamin A J. gen. Virol. 29, 315–324 (1975)..
Blalock, J E, Gifford, G E.: Suppression of interferon production by vitamin A J. gen. Virol. 32, 143–147 (1976).
Blalock, J E, Gifford, G E.: Comparison of the suppression of interferon production and inhibition of its action by vitamin A and related compounds. Proc. Soc. exp. Biol. 153, 298–300 (1976).
Blalock, J E, Gifford, G E.: Retinoic acid (vitamin A acid) induced transcriptional control of interferon production. Proc. nat. Acad. Sci. (Wash.) 74 (No. 12), 5382–5386 (1977).
Boyle, J, Dick, D C, Mackie, R M.: Treatment of extensive virus warts with etretinate (Tigason) in a patient with sarcoidosis. Clin. exp. Derm. 8, 33–36 (1983).
Bradshwaw, D, Cashin, C H, Kennedy, A J.: Anti-inflammatory effects of the retinoids. In: Cuncliff, WJ, Miller, A J. (eds.): Retinoid therapy, pp 335–343 (1983).
Breitman, T R, Selonick, S E, Collins, S J.: Induction of differentiation of the human promyelocy-tic leukemia cell line (HL-60) by retinoic acid. Proc. nat. Acad. Sci. (Wash.) 77, 2936–2940 (1980).
Bryant, R L, Barnett, J B.: Adjuvant properties of retinol on IgE production in mice. Int. Arch. Allergy 59, 69–74 (1979).
Camisa, C, Eisenstat, B, Ragaz, A, Weissmann, G: The effects of retinoids on neutrophil functions in vitro. J. Amer. Acad. Derm. 6, 620–629 (1982).
Cloudy, A L, Rouchouse, B, Boucheron, S, Le Petit, J C: Treatment of cutaneous lymphoma with etretinate. Brit. J. Derm. 109, 49–56 (1983).
Cohen, B E, Cohen, I K.: Vitamin A. Adjuvant and steroid antagonist in the immune response. J. Immun. (Baltimore) 111, 1376–1380 (1973).
Darip, M D, Sirisinha, S, Lamb, A J.: Effect of vitamin A deficiency on susceptibility of rats to An giostrongylus cantonensis. Proc. Soc. exp. Biol. 161, 600–604 (1979).
Dennert, G, Lotan, R.: Effects of retinoic acid on the immune system stimulation of T killer cell induction. Europ. J. Immun. 8, 23–29 (1978).
Dicken, C H.: Retinoids: a review. J. Amer. Acad. Derm. 11, 541–552 (1984).
Dingle, J T.: Studies on the mode of action of excess vitamin A. 3. Release of bound protease by the action of vitamin A. Biochem. J. 79, 509–512 (1961).
Dresser, D W.: Adjuvanticity of vitamin A. Nature (Lond.) 217, 527–529 (1968).
Dubertret, L, Lebreton, C, Touraine, R.: Inhibition of neutrophil migration by etretinate and its main metabolite. Brit. J. Derm. 107, 681–690 (1982).
Edelman, G M, Cunningham, B A, Reeke, G N, Becker, J W, Waxdall, M J, Wang, J L.: The conva-lent and three-dimensional structure of concanavalin. Proc. nat. Acad. Sci. (Wash.) 69, 2580–2584 (1972).
Edelson, Y, Beretti, B, Grupper, C: Treatment of epidermodysplasia verruciformis or multiple ver-rucae planae by oral aromatic retinoid (Ro 10-9359 — Tigason). In: Orfanos, C E, Braun-Falco, O, Farber, E M. (eds.): Retinoid. Advances in basic research and therapy. Berlin, Springer-Verlag, p 446 (1981).
Engel, H J, Schütz, R.: Leukocyten — Rana esculenta. Publ. Wiss. Film Sekt. Med. 3, 233–247 (1976).
Falchuck, K R, Walker, W A, Perotto, J L, Isselbucher, KJ.: Affect of vitamin A on the systemic and local antibody responses to intragastrically administered bovine serum albumin. Infect. Immun. (Wash.) 17, 361–365 (1977).
Felix, E L, Loyd, B, Cohen, M H.: Inhibition of the growth and development of a transplantable murine melanoma by vitamin A. Science (N.Y.) 189, 886–888 (1975).
Fell, H B, Dingle, J T.: Studies on the mode of action of excess vitamin A 6. Lysosomal protease and the degradation of cartilage matrix. Biochem. J. 87, 403–408 (1963).
Floersheim, G L, Bollag, W.: Accelerated rejection of skin homograft by vitamin A acid. Transplantation (Baltimore) 15 (No. 4), 564–567 (1972).
Flynn, P J, Miller, W J, Weisdorf, D J, Arthur, D C, Brunning, R, Branda, R F: Retinoic acid treatment of acute promyelocytic leukemia: in vitro and in vivo observations. Blood 62, 1211–1217 (1983).
Frank, M.: Zur Frage der Resistenzverminderung gegen Infektionen bei der A-Avitaminose. Med. Klin. 15, 486–488 (1935).
Fredriksson, T.: Oral treatment of psoriasis and pustulosis palmo-plantaris with Ro 10-9359. Der-matologica (Basel) 157, Suppl. 1, 13–18 (1978).
Glauert, A M, Daniel, M R, Luca, J A, Dingle, J T.: Studies on the mode of action of excess of vitamin A VII. Changes in the fine structure of erythrocytes during hemolysis by vitamin A. J. Cell. Biol. 17, 111–121 (1963).
Gold, E J, Mertelsmann, R H, Itri, L M, Gee, T, Arlin, Z, Kempin, S, Clarkson, B, Moore, M A S.: Phase I clinical trial of 13-cis-retinoic acid in myelodysplastic syndromes. Cancer Treatm. Rep. 67, 981–986 (1983).
Goldfarb, R H, Herberman, R B.: Natural killer cell reactivity regulatory interactions among phor-bol ester, interferon, cholera toxin, and retinoic acid. J. Immun. (Baltimore) 126, 2129–2135 (1981).
Gresser, L: On the mechanisms of the antitumor effects of interferon. Tex. Rep. Biol. Med. 35, 394–398 (1977).
Grupper, C H, Berretti, B.: Lupus erythematosus and etretinate. In: Cuncliffe, W J, Miller, A J. (eds.): Retinoid therapy pp 73–81 (1983).
Hamaoka, T, Katz, D, Benacerraf, B.: Hapten-specific IgE antibody responses in mice. II. Cooperative interactions between adoptively transferred T and B lymphocytes in the development of IgE. J. exp. Med. 138, 538–556 (1973).
Herberman, R B, Ortaldo, J R, Bonnard, G D.: Augmentation by interferon of human natural and antibody-dependent cell-mediated cytotoxicity. Nature (Lond.) 277, 221–223 (1978).
Hersle, K, Mobacken, H, Sloberg, K, Thilander, H.: Severe oral lichen planus: treatment with an aromatic retinoid (etretinate). Brit. J. Derm. 106, 77–80 (1982).
Jablonska, S, Obalek, S, Wolska, H, Jarzabek-Chorzelska, M.: Ro 10-9359 in epidermodysplasia verruciformis. Preliminary report In: Orfanos, C E, Braun-Falco, O, Farber, E M. (eds.): Retinoids. Advances in basic research and therapy. Berlin, Springer-Verlag pp 401–405 (1981).
Jurin, M, Tannock, I F.: Influence of vitamin A on immunological response. Immunology 23, 283–287 (1982).
Kessler, J F, Meyskens, F Ljr, Levine, N, Lynch, P Y, Jones, S E.: Treatment of cutaneous T-cell lymphoma (mycosis fungoides) with 13-cis-retinoic acid. Lancet 1, 1345–1347 (1983).
Knippel, I, Bauer, R, Orfanos, C E.: No influence of three synthetic retinoids (Ro 10-1670, Ro 4-3780, Ro 13-6298) on lipoxygenase activity in two in vitro systems. In: Cuncliffe, W J, Miller, A J. (eds.): Retinoid therapy, pp 345–347 (1983).
Krishnan, S, Bhuyan, U N, Talwar, G P, Ramalingaswami, V.: Effect of vitamin A and protein calorie undernutrition on immune responses. Immunology 27, 383–392 (1984).
Krishnan, S, Krishnan, A D, Mustafa, A S, Talwar, G P, Ramalingaswami, V.: Effect of vitamin A and undernutrition on the susceptibility of rodents to a malarial parasite Plasmodium berghei. J. Nutr. 106, 784–791 (1976).
Lassen, H.: Z. Immunforsch. 73 (1932). Zitiert aus: Frank, M.: Zur Frage der Resistenzverminderung gegen Infektionen bei der A-Avitaminose. Med. Klin. 15, 486–488 (1935).
Lee, W I, Radett, B, Shalita, A R.: Effect of isotretinoin on neutrophil function. Clin. Res. 31, 518 a (1983).
Levine L, Ohuchi, K.: Retinoids as well as tumor promoters enhance deacylation of cellular lipids and prostaglandin production in MDCK cells. Nature (Lond.) 276, 274–275 (1978).
Lindsahl, P, Leary, P, Gresser, I.: Enhancement by interferon of the specific cytotoxicity of sensitized lymphocytes. Proc. nat. Acad. Sci. (Wash.) 69, 721–725 (1972).
Lotan, R.: Effects of vitamin A and its analogs (retinoids on normal and neoplastic cells). Biochem. Biophys. Acta 605, 33–91 (1980).
Lotan, R, Dennert, G.: Stimulatory effects of vitamin A on induction of cell-mediated cytotoxicity in vivo. Cancer Res. 39, 55–58 (1979).
Lotan, R, Nicolson, G L: Inhibitory effects of retinoic acid or retinyl acetate on the growth of un-transformed, transformed, and tumor cell lines in vitro. J. nat. Cancer Inst. 59, 1717–1722 (1977).
Lucy, J A, Dingle, J T.: Fat soluble vitamins and biological membranes. Nature (Lond.) 204, 156–160 (1964).
Lutzner, M A, Blanchet-Bardon, C, Puissant, A.: Oral aromatic retinoid (Ro 10-9359) treatment of two patients suffering with the severe form of epidermodysplasia verruciformis. In: Orfanos, C E, Braun-Falco, O, Färber, E M. (eds.): Retinoids. Advances in basic research and therapy. Berlin, Springer-Verlag, pp 407–410 (1981).
Marks, R, Finlay, A, Nicholls, S, Barton, S.: The effects of retinoids on stratum corneum. Structure and function. In: Orfanos, C E, Braun-Falco, O, Färber, E M. (eds.): Retinoids. Advances in basic research and therapy. Berlin, Springer-Verlag, pp 77–83 (1981).
Maujid, B, Sirisinha, S, Lamb, A J.: The effect of vitamin A and protein deficiency on complement levels in rats. Proc. Soc. exp. Biol. 158, 92–95 (1978).
Meeks, R G, Chen, R F: TTie effect of membrane detergents and retinoic acid on membrane micro-viscosity. Fed. Proc. 38, 540 (1979).
Meltzer, M S, Cohen, B E.: Tumor suppression by Mycobacterium bovis (strain BCG) enhanced by vitamin A. J. Nat. Cancer Inst. 53, 585–587 (1974).
Meyskens, F L, Salmon, S E.: Inhibition of human melanoma colony formation by retinoids. Cancer Res. 39, 4055–4057 (1979).
Micksche, M, Cerni, C, Kokron, O, Titscher, R, Wrba, H.: Stimulation of immune response in lung cancer patients by vitamin A therapy. Oncology 234–238 (1977).
Nauss, K M, Mark, D A, Suskind, R M.: The effect of vitamin A deficiency on the in vitro cellular immune response of rats. J. Nutr. 109, 1815–1823 (1979).
Okudaira, J, Ishizaka, K.: Reaginic antibody formation in the mouse. III. Collaboration between hapten-specific memory cells and carrier specific helper cells for secondary antihapten antibody formation. J. Immun. (Baltimore) 113, 563–573 (1974).
Orfanos, C E.: Oral retinoids. Present status. Brit. J. Derm. 103, 473–481 (1980).
Orfanos, C E, Bauer, R.: Evidence for anti-inflammatory activities of oral synthetic retinoids. Brit. J. Derm. 109, Suppl. 25, 55–60 (1983).
Orfanos, C E, Braun-Falco, O, Färber, E M. (eds.): Retinoids. Advances in basic research and therapy. Berlin, Springer-Verlag (1981).
Orfanos, C E, Mahrle, G, Goerz, G, Happle, R, Hofbauer, M, Landes, E, Schimpf, A.: Laboratory investigations in patients with generalized psoriasis under oral retinoid treatment. A multicenter study of computerized data. Dermatologica (Basel) 159, 62–70 (1979).
Patek, P Q, Collins, J L, Yogeeswaran, G, Dennert, G.: Antitumor potential of retinoic acid: stimulation of immune mediated effectors. Int. J. Cancer 24, 624–628 (1979).
Pickett-Heaps, J D.: Aspects of spindle evolution. Ann. N.Y. Acad. Sci. 253, 352–361 (1975).
Piagatto, P D, Fioroni, A, Riva, F, Brogo, M A, Morandotti, A, Altomare, G F, Finzi, A F: Effects of isotretinoin on the neutrophil chemotaxis in cystic acne. Dermatologica (Basel) 167, 16–18 (1983).
Plewig, G, Wagner, A.: Anti-inflammatory effects of 13-cis-retinoic acid. Arch. derm. Res. 270, 89–94 (1981).
Poretz, R D, Goldstein, I J.: Protein-carbohydrate interaction. On the mode of binding of aromatic moieties to concanavalin A, the phytohemagglutin of the jack bean. Biochem. Pharmacol. 20, 2727–2739 (1971).
Rhodes, J.: Human interferon action: reciprocal regulation by retinoic and ß-carotene. J. nat. Cancer Inst. 70, 833 (1983).
Rhodes, J. Oliver, S.: Retinoids as regulators of macrophage function. Immunology 40, 467–472 (1980).
Rhodes, J, Stokes, P, Abrams, P.: Human tumor-induced inhibition of interferon action in vitro: reversal of inhibition by β-carotene (pro-vitamin A). Cancer Immun. Immunother. 16, 189–192 (1984).
Ruzicka, T, Meurer, M.: Behandlung des cutanen Lupus erythematodes mit dem aromatischen Retinoid Tigason (Etretinat). Zbl. Haut-u. Geschl.-Kr. 150, Heft 8, 655–656 (1985).
Sani, B P, Hill, D L.: Retinoic acid-A binding protein in chick embryo metatarsal skin. Biochem. Biophys. Res. Commun. 61, 1276–1282 (1984).
Sani, B P, Hill, D L.: A retinoic acid-binding protein from chick skin. Cancer Res. 36, 404–413 (1976).
Saurat, J H, Didierjean, L, Gluckman, E, Bussel, A.: Graft versus host reaction and lichen planus-like eruption in man. Brit. J. Derm. 92, 591–592 (1985).
Saurat, J H, Gluckman, E, Bussel, A, Didierjean, L, Puissant, A.: The lichen planus-like eruption after bone marrow transplantation. Brit. J. Derm. 92, 675–681 (1975).
Schliwa, M, Euteneuer, U, Herzog, W, Weber, K.: Evidence for rapid structural and functional changes of the melanophore microtubule-organizing center upon pigment movements. J. Cell Biol. 83, 623–632 (1979).
Schuppli, R.: The efficacy of the new retinoid (Ro 10-9359) in lichen planus. Dermatologica (Basel) 157, Suppl. 1, 60–63 (1978).
Scrimshaw, N S, Taylor, C E, Gordon, J E.: Interaction of nutrition and infection. WHO Monog. Ser. No 57 (1968).
Shalita, A R, Konecky, E A, Kee, W L.: Effect of isotretinoin on neutrophil chemotaxis and phagocytosis in acne conglobata. Clin. Res. 30, 608a (1982).
Sidell, N, Famatiga, E, Golub, S H: Augmentation of human thymocyte proliferative responses by retinoic acid. Exp. Cell Biol. 49, 239–245 (1981).
Sirisinha, S, Darip, M D, Moonkardni, P, Ongsakul, M, Lamb, A J.: Impaired local immune response in vitamin A-deficient rats. Clin. exp. Immun. 40, 127–135 (1980).
Sirisinha, S, Suskind, R, Edelman, R, Asvapaka, C, Olson, R E.: Secretory and serum IgA in children with protein calorie malnutrition. Pediatrics 55, 166–170 (1975).
Solomon, F: Organizing microtubules in the cytoplasm. Cell 22, 331–332 (1980).
Sonis, S, Shklar, G.: Preliminary immunologie studies on retinoid inhibition of experimental carci-nogenesis. J. oral Med. 36, 117–120 (1981).
Spitznagel, J K, Allison, A C: Mode of action of adjuvants: retinol and other lysosome-labilizing agents as adjuvants. J. Immun. (Baltimore) 101, 119–127 (1970).
Sporn, M B, Clamon, G H, Dunlop, N M, Newton, D L, Smith, J M, Safflotti, U.: Activity of vitamin A analogues in cell culture of mouse epidermis and organ cultures of hamster trachea. Nature (Lond.) 253, 47–50 (1975).
Sporn, M B, Newton, D L.: Chemoprevention of cancer with retinoids. Fed. Proc. 38, 2528–2534 (1979).
Stadler, R, Orfanos, C E.: Erythema anulare centrifugum mit Pustulation. Hautarzt 32, 564–566 (1981).
Strickland, S, Mahdavi, V.: The induction of differentiation in tetracarcinoma stem cells by retinoic acid. Cell 15, 393–403 (1978).
Suskind, R M.: Malnutrition and the immune response. Raven Press. New York (1977).
Taub, R N, Krabtz, A R, Dresser, D W.: The effect of localized injection of adjuvant material on the draining lymph node. J. Histol. Immun. 18, 171–186 (1970).
Todaro, G J, De Larco, J E, Sporn, M B.: Retinoids block phenotypic cell transformation produced by sarcoma growth factor. Nature (Lond.) 276, 272–274 (1978).
Tsambaos, D, Orfanos, C E.: Ultrastructural evidence suggesting an immunomodulatory activity of oral retinoid. Brit. J. Derm. 104, 37–45 (1981).
Waldinger, T P, Ellis, C N, Quint, K, Voorhees, J J.: Treatment of cutaneous sarcoidosis with isotretinoin. Arch. Derm. (Chicago) 119, 1003–1105 (1983).
Ziboh, V A, Price, B, Fulton, J.: Effects of retinoic acid on prostaglandin biosynthesis in guinea — pig skin. J. invest. Derm. 63, 370–374 (1975).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Bauer, R., Kreysel, H.W. (1987). Retinoide und Immunologie Physiologische und pharmakologische Wirkungen natürlicher und synthetischer Retinoide auf die Immunantwort. In: Hornstein, O.P., Hundeiker, M., Schönfeld, J. (eds) Neue Entwicklungen in der Dermatologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72828-0_3
Download citation
DOI: https://doi.org/10.1007/978-3-642-72828-0_3
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-18063-0
Online ISBN: 978-3-642-72828-0
eBook Packages: Springer Book Archive