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Intrathecal Baclofen in Spasticity

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Local-spinal Therapy of Spasticity

Abstract

The syndrome of spasticity still confronts us with several unsolved problems in the theoretical as well as in the clinical field.

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References

  1. Angel RW, Hofmann WW (1963) The H reflex in normal, spastic and rigid subjects. Arch Neurol 8:591–596

    Article  Google Scholar 

  2. Andrews PLR, Wood KL (1986) Systemic baclofen stimulates gastric motility and secretion via a central action in the rat. Br J Pharmacol 89:461–467

    PubMed  CAS  Google Scholar 

  3. Aptekar RG, Ford F, Bleck EE (1976) Light patterns as a mean of assessing and recording gait. Part 1: Methods and results in normal children. Dev Med Child Neurol 18:31–36

    Article  PubMed  CAS  Google Scholar 

  4. Aptekar RG, Ford F, Bleck EE (1976) Light patterns as a mean of assessing and recording gait. Part 2: Results in children with cerebral palsy. Dev Med Child Neurol 18:37–40

    Article  PubMed  CAS  Google Scholar 

  5. Aring CD (1973) Pain in multiple sclerosis. J Am Med Assoc 223:547

    Article  CAS  Google Scholar 

  6. Ashworth B (1964) Preliminary trial of carisoprodol in multiple sclerosis. Practitioner 192:540–542

    PubMed  CAS  Google Scholar 

  7. Ault A, Evans HE (1981) The depressant action of baclofen on the isolated spinal cord of the neonatal rat. Eur J Pharmacol 71:357–364

    Article  PubMed  CAS  Google Scholar 

  8. Ault B, Nadler JV (1983) Anticonvulsant-like actions of baclofen in the rat hippocampal slice. Br J Pharmacol 78:701–708

    PubMed  CAS  Google Scholar 

  9. Awapara J (1950) Detection and identification of metabolites in tissued by means of paper chromatography. Fed Proc 9:148

    Google Scholar 

  10. Badr GG, Matousek M, Frederiksen PK (1983) A quantitative EEG analysis of the effects of baclofen on man. Neuropsycho-biology 10:13–18

    Article  CAS  Google Scholar 

  11. Barker I, Grant I (1982) Convulsions after abrupt withdrawal of baclofen. Lancet II:556–557

    Article  Google Scholar 

  12. Basmajian JV (1975) Lioresal treatment of spasticity in multiple sclerosis. Am J Phys Med 54:175–177

    PubMed  CAS  Google Scholar 

  13. Baum E (1981) Motographie 1. Bundesanstalt für Arbeitsschutz, Wirtschaftsverlag

    Google Scholar 

  14. Bayerl JR, Gruia D (1985) Klinische Vergleichsstudie der Antispastika Memantin und Baclofen. Therapiewoche 35:5440–5444

    Google Scholar 

  15. Bazemore AW, Elliott KAC, Florey E (1957) Isolation of factor I. J Neurochem 1:334–339

    Article  CAS  Google Scholar 

  16. Ben-Ari J, Henry JL (1976) Effects of the parchlorphenyl derivate of GAB A on spinal neurones in the cat. J Physiol (Lond) 259:469–470

    Google Scholar 

  17. Benecke R, Conrad B, Höhne J, Meinck HM (1983) Quantitative analyses of the effect of antispastic drugs upon locomotor activity. Agressologie 24:147–149

    Google Scholar 

  18. Benecke R, Conrad B, Meinck HM (1984) Neue Erkenntnisse zur Pathophysiologie der Spastizität. In: Conrad B, Benecke R, Bauer HJ (eds) Die klinische Wertung der Spastizität. Schattauer, Stuttgart New York, pp 17–31

    Google Scholar 

  19. Benedito MAC, Leite JR (1981) Baclofen as an anticonvulsant in experimental models of convulsions. Exp Neurol 72:346–351

    Article  PubMed  CAS  Google Scholar 

  20. Bergamini L, Riccio A, Bergamasco B (1966) Un farmaco ad azione antispastica della musculatura striata. Sperimentatione clinica di un derivato del GABA. Minerva Med 57:2723–2725

    PubMed  CAS  Google Scholar 

  21. Birkmayer W (1972) Spasticity — a topical survey. Huber, Wien

    Google Scholar 

  22. Bousquet P, Feldman J, Bloch R, Schwartz J (1981) The central hypotensive action of baclofen in the anaesthetized cat. Eur J Pharmacol 76:193–201

    Article  PubMed  CAS  Google Scholar 

  23. Bowery NG (1982) Baclofen 10 years on. Trends Pharmacol Sci 3:400–403

    Article  CAS  Google Scholar 

  24. Bowery NG (1983) Le Baclofene tel qu’il se présente au bout de dix ans. Gaz Med Fr 90:2891–2897

    Google Scholar 

  25. Bowery NG, Hill DR, Hudson AL, Doble A, Middlemiss DN, Shaw J, Turnhull M (1980) (-)Baclofen decreases neurotransmitter release in the mammalian CNS by action at a novel GABA receptor. Nature 283:92–94

    Article  PubMed  CAS  Google Scholar 

  26. Brill B, Greve J (1985) Photographische Bewegungsanalyse bei neurologischen Störungen und ihre Bedeutung für die Rehabilitation. In: Schimrigk K, Haaß A (eds) Zentrale Bewegungsstörungen — Arzneimittelinterferenzen. Perimed, Erlangen, pp 37–54

    Google Scholar 

  27. Brodie BB (1960) The importance of dissociation constant and lipid-solubility in influencing the passage of drugs into the cerebrospinal fluid. J Pharmacol Exp Ther 130:20–25

    PubMed  CAS  Google Scholar 

  28. Burke D, Andrews C, Knowles L (1971) The action of a GABA derivate in human spasticity. J Neurol Sci 14:199–208

    Article  PubMed  CAS  Google Scholar 

  29. Burke D, Gillies DJ, Lance JW (1970) The quadriceps stretch reflex in human spasticity. J Neurol Neurosurg Psychiatry 33:216–223

    Article  PubMed  CAS  Google Scholar 

  30. Capek R, Esplin B (1982) Baclofen-induced decrease of excitability of primary afferents and depression of monosynaptic transmission in cat spinal cord. Can J Physiol Pharmacol 60:160–167

    Article  PubMed  CAS  Google Scholar 

  31. Cartlidge NEF, Hudgson P, Weightman D (1974) A comparison of baclofen and diazepam in the treatment of spasticity. J Neurol Sci 23:17–24

    Article  PubMed  CAS  Google Scholar 

  32. Cendrowski W, Sobczyk W (1977) Clonazepam, baclofen and placebo in the treatment of spasticity. Eur Neurol 16: 257–262

    Article  PubMed  CAS  Google Scholar 

  33. Chahl LA, Walker SB (1980) The effect of baclofen on the cardiovascular system of the rat. Br J Pharmacol 69:631–637

    PubMed  CAS  Google Scholar 

  34. Coletti A, Mandelli A, Minoli G, Tredici EP (1980) Post-anoxic action myoclonus (Lance-Adams syndrome) treated with levodopa and gabaergic drugs. J Neurol 223:67–70

    Article  PubMed  CAS  Google Scholar 

  35. Conrad B, Benecke R (1985) Bewegungsanalyse zentralmotorischer Krankheiten als Mittel der Therapiekontrolle. In: Schimrigk K, Haaß A (eds) Zentrale Bewegungsstörungen — Arzneimittelinterferenzen. Perimed, Erlangen, pp 55–63

    Google Scholar 

  36. Conrad B, Benecke R, Meinck HM (1984) Qualitative and quantitative Aspekte der spastischen Bewegungsstörung der unteren Extremität. In: Conrad B, Benecke R, Bauer HJ (eds) Die klinische Wertung der Spastizität. Schattauer, Stuttgart New York, pp 73–84

    Google Scholar 

  37. Corli O, Roma G, Bacchini M, Battagliarin G, Di Piazza D, Brambilla C, Grossi E (1984) Double-blind placebo-controlled trial of baclofen, alone and in combination, in patients undergoing voluntary abortion. Clin Ther 6:800–807

    PubMed  CAS  Google Scholar 

  38. Corston RN, Johnson F, Godwin-Austen RB (1981) The assessment of drug treatment of spastic gait. J Neurol Neurosurg Psychiatry 44:1035–1039

    Article  PubMed  CAS  Google Scholar 

  39. Curtis DR, Game CJA, Johnston GAR, McCulloch RM (1974) Central effects of β-(p-chlorphenyl)-gamma-aminobutyric acid. Brain Res 70:493–500

    Article  PubMed  CAS  Google Scholar 

  40. Curtis DR, Lodge D, Bornstein JC, Peet MJ (1981) Selective effect of (-)baclofen on spinal synaptic transmission in the cat. Exp Brain Res 42:158–170

    Article  PubMed  CAS  Google Scholar 

  41. Curtis DR, Johnston GAR (1974) Amino acid transmitters in the mammalian central nervous system. Ergeb Physiol 69:97–188

    PubMed  CAS  Google Scholar 

  42. Cutting DA, Jordan CC (1975) Alternative approach to analgesia: Baclofen as a model compound. Br J Pharmacol 54:171–176

    PubMed  CAS  Google Scholar 

  43. Davidoff RA (1980) Effects of baclofen on synaptic activity in the spinal cord. In: Feldman RG, Young RR, Koella WP (eds) Spasticity: Disordered motor control. Year Book, Chicago, pp 421–436

    Google Scholar 

  44. Davidoff RA, Sears ES (1974) The effects of Lioresal on synaptic activity in the isolated spinal cord. Neurology 24:957–963

    PubMed  CAS  Google Scholar 

  45. Davies J (1981) Selective depression of synaptic excitation in cat spinal neurons by baclofen: an iontophoretic study. Br J Pharmacol 72:373–384

    PubMed  CAS  Google Scholar 

  46. Defeudis FV (1982) Studies on GABA and cardiovascular function using in vivo and in vitro technics. Drug Develop Res 2:507–517

    Article  CAS  Google Scholar 

  47. Defeudis FV (1983) Gamma-aminobutyric acid and cardiovascular function. Experientia 39:845–849

    Article  PubMed  CAS  Google Scholar 

  48. Delwaide PJ (1985) Electrophysiological analysis of the mode of action of muscle relaxants in spasticity. Ann Neurol 17:90–95

    Article  PubMed  CAS  Google Scholar 

  49. Delwaide PJ, Cordonnier M (1977) Traitement médicamenteux de la spasticité. Méd Hyg 35:2053–2061

    Google Scholar 

  50. Delwaide PJ, Cordonnier M, Gadea-Ciria M (1978) Excitability relationship between lower limb myotactic arcs in spasticity. J Neurol Neurosurg Psychiatry 41:636–641

    Article  PubMed  CAS  Google Scholar 

  51. Delwaide PJ, Martinelli P, Crenna P (1980) Clinical neurophysiological measurement of spinal reflex activity. In: Feldman RG, Young GG, Koalla WP (eds) Spasticity: disordered motor control. Year Book, Chicago, pp 345–371

    Google Scholar 

  52. Delwaide P, Schoenen J (1984) Auswahl des Antispastikums unter besonderer Berücksichtigung der jeweils vorliegenden Pathophysiologie der Spastizität. In: Conrad B, Benecke R, Bauer HJ (eds) Die klinische Wertung der Spastizität. Schattauer, Stuttgart New York, pp 91–96

    Google Scholar 

  53. Di Chiro G (1966) Observations on the circulation of the cerebrospinal fluid. Acta Radiol [Diagn] (Stockh) 5:988–996

    Google Scholar 

  54. Dickinson AH, Brewer CM, Hayes NA (1985) Effect of topical baclofen on C-fibre-evoked neuronal activity in the rat dorsal horn. Neuroscience 14:557–562

    Article  Google Scholar 

  55. Dimitrijevic MR, Nathan PW (1967) Studies of spasticity in man. 2. Analysis of stretch reflexes in spasticity. Brain 90:333–358

    Article  PubMed  CAS  Google Scholar 

  56. Dimitrijevic MR, Sherwood AM (1980) Spasticity: medical and surgical treatment. Neurology 30:19–27

    PubMed  CAS  Google Scholar 

  57. Drayer BP, Rosenbaum AE (1978) Studies of the third circulation. J Neurosurg 48:946–953

    Article  PubMed  CAS  Google Scholar 

  58. Duncan GW, Shahani BT, Young RR (1976) An evaluation of baclofen treatment for certain symptoms in patients with spinal cord lesions: a double-blind cross over study. Neurology (Minneapolis) 26:441–446

    CAS  Google Scholar 

  59. Dunlap K (1981) Two types of gamma-aminobutyric acid receptors on embryonic sensory neurones. Br J Pharmacol 74:579–585

    PubMed  CAS  Google Scholar 

  60. Enna SJ, Maggi A (1979) Biochemical pharmacology of gabaergic agonists. Life Sci 24:1727–1738

    Article  PubMed  CAS  Google Scholar 

  61. Fehr HU, Bein HJ (1974) Sites of action of a new muscle relaxant (baclofen, Lioresal, CIBA 34 647-Ba). J Int Med Res 2:36–47

    CAS  Google Scholar 

  62. Feldman RG, Kelly-Hayes M, Comony JP, Foley JM (1978) Baclofen for spasticity in multiple sclerosis: double-blind crossover and three-year study. Neurology 28:1094–1098

    PubMed  CAS  Google Scholar 

  63. Florey E (1954) An inhibitory and an excitatory factor of mammalian central nervous system, and their actions on a single sensory neuron. Arch Int Physiol 62:33–53

    Article  PubMed  CAS  Google Scholar 

  64. Foerster O (1911) Die Behandlung spastischer Lähmungen durch Resektion hinterer Rückenmarkswurzeln. Ergeb Chir 2:174–209

    Google Scholar 

  65. Fox S, Krnjević K, Morris ME, Puil E, Werman R (1978) Action of baclofen on mammalian synaptic transmission. Neuroscience 3:495–515

    Article  PubMed  CAS  Google Scholar 

  66. From A, Heltberg A (1975) A double-blind trial with baclofen and diazepam in spasticity due to multiple sclerosis. Acta Neurol Scand 51:158–166

    Article  PubMed  CAS  Google Scholar 

  67. Fromm GH, Terrence CF, Chattha AS, Glass JD (1980) Baclofen in trigeminal neuralgia. Its effect on the spinal trigeminal nucleus: a pilot study. Arch Neurol 37:768–771

    Article  PubMed  CAS  Google Scholar 

  68. Fung SC, Swarbrick MJ, Fillenz M (1985) Effect of baclofen on in vitro noradrenaline release from rat hippocampus and cerebellum: an action at an alpha2-adrenoceptor. Neurochem Int 7:155–163

    Article  PubMed  CAS  Google Scholar 

  69. Fukuda H, Kudo Y, Ono H (1977) Effects of β-(p-chlorphenyl-)GABA (baclofen) on spinal synaptic activity. Eur J Pharmacol 44:17–24

    Article  PubMed  CAS  Google Scholar 

  70. Gemer HJ, Rauda DW, Witterstätter K (1979) Die soziale Situation von Querschnittgelähmten. Eine empirische Untersuchung. Rehabilitation 18:135–149

    Google Scholar 

  71. Gerschenfeld HM (1973) Chemical transmission in invertebrate central nervous systems and neuromuscular junction. Physiol Rev 53:1–119

    PubMed  CAS  Google Scholar 

  72. Ghose K, Holmes KM, Matthewson K (1980) Complications of baclofen overdosage. Postgrad Med J 56:865–867

    Article  PubMed  CAS  Google Scholar 

  73. Gillis RA, Yamada KA, Dimicco JA, Williford DJ, Segal SA, Hamosh P, Norman WP (1984) Central gamma-aminobutyric acid involvement in blood pressure control. Fed Proc 43:32–38

    PubMed  CAS  Google Scholar 

  74. Gray JA, Metz A, Goodwin GM, Green AR (1986) The effect of GABA-mimetic drugs, progabide and baclofen, on the biochemistry and function of 5-hydroxytryptamine and noradrenaline. Neuropharmacology 25:711–716

    Article  PubMed  CAS  Google Scholar 

  75. Green AR (1986) Changes in GABA biochemistry and seizure threshold. Ann NY Acad Sci 462:105–119

    Article  PubMed  CAS  Google Scholar 

  76. Hammond DL, Drower EJ (1984) Effects of intrathecally administered THIP, baclofen and muscimol on nociceptive threshold. Eur J Pharmacol 103:121–125

    Article  PubMed  CAS  Google Scholar 

  77. Hassan N, McLellan DL (1980) Double-blind comparison of single doses of DS 103-282, baclofen and placebo for suppression of spasticity. J Neurol Neurosurg Psychiatry 43:1132–1136

    Article  PubMed  CAS  Google Scholar 

  78. Hassler R (1981) Neuronale Grundlagen der spastischen Tonussteigerung. In: Bauer HJ, Koella WP, Struppler A (eds) Therapie der Spastik. Verlag für angewandte Wissenschaften, München, pp 11–38

    Google Scholar 

  79. Hattab JR (1980) Review of European trials with baclofen. In: Feldman RG, Young RR, Koella WP (eds) Spasticity: disordered motor control. Symposia Specialists, Miami, pp 71–75

    Google Scholar 

  80. Hayashi T, Nagai K (1956) Action of amino acids on the motor cortex of higher animals, especially γ-amino-β oxybutyric acid as a real inhibitory principle in brain. Proc XX Int Physiol Congress:410

    Google Scholar 

  81. Head H, Riddoch G (1917) The automatic bladder, excessive sweating and some other reflex conditions in gross injuries of the spinal cord. Brain 40:188–263

    Article  Google Scholar 

  82. Hedley DW, Maroun JA, Espir MLE (1975) Evaluation of baclofen for spasticity in multiple sclerosis. Postgrad Med J 51:615–622

    Article  PubMed  CAS  Google Scholar 

  83. Henry JL (1980) Pharmacologic studies on baclofen in the spinal cord of the cat. In: Feldman RG, Young RR, Koella WP (eds) Spasticity: disordered motor control. Year Book, Chicago, pp 437–452

    Google Scholar 

  84. Herman R (1970) The myotactic reflex: Clinico-physiological aspects of spasticity and contracture. Brain 99:237–312

    Google Scholar 

  85. Howe JR, Zieglgänsberger W (1986) D-Baclofen does not antagonize the actions of l-baclofen on rat neocortical neurons in vitro. Neurosci Lett 72:99–104

    Article  PubMed  CAS  Google Scholar 

  86. Hudgson P, Weightman D (1971) Baclofen in the treatment of spasticity. Br Med J 4:15–18

    Article  PubMed  CAS  Google Scholar 

  87. Hyser CL, Drake ME (1984) Status epilepticus after baclofen withdrawal. J Natl Med Assoc 76:533–538

    PubMed  CAS  Google Scholar 

  88. Jensen D (1979) Spastiske nedre urinveier. Er det indisert med. In: Dietrichson P, Nyberg-Hansen R (eds) Spastisotet og rigiditet. Cyba-Geigy, Switzerland, pp 259–271

    Google Scholar 

  89. Johnston GAR, Hailstone MH, Freeman CG (1980) Baclofen: stereo-selective inhibition of excitant amino acid release. J Pharm Pharmacol 32:230–231

    Article  PubMed  CAS  Google Scholar 

  90. Jones RF, Burke D, Marosszeky JE, Gillies JD (1970) A new agent for the control of spasticity. J Neurol Neurosurg Psychiatry 33:464–468

    Article  PubMed  CAS  Google Scholar 

  91. Jones RF, Lance JW (1976) Baclofen in the long-term management of spasticity. Med J Aust 1:654–657

    PubMed  CAS  Google Scholar 

  92. Kehoe JS, Marder E (1976) Identification and effects of neural transmitters in invertebrates. Annu Rev Pharmacol 16:245–268

    Article  CAS  Google Scholar 

  93. Koella WP (1980) Baclofen: its general pharmacology and neuropharmacology. In: Feldman RG, Young GG, Koalla WP (eds) Spasticity: disordered motor control. Year Book, Chicago, pp 383–396

    Google Scholar 

  94. Krogsgaard-Larsen P, Scheel-Kruger J, Kofod H (1979) GABA-neurotransmitters. Academic Press, New York

    Google Scholar 

  95. Krnjevic K (1974) Chemical nature of synaptic transmission in vertebrates. Physiol Rev 54:418–540

    CAS  Google Scholar 

  96. Kurnick NB (1956) Autonomic hyperreflexia and its control in patients with spinal cord lesions. Ann Intern Med 44:678–686

    PubMed  CAS  Google Scholar 

  97. Lalley PM (1980) Unexpected disinhibitory effects of baclofen on cardiovascular and respiratory neurons. Brain Res Bull 5:565–573

    Article  CAS  Google Scholar 

  98. Lalley PM (1980) Inhibition of depressor cardiovascular reflexes by a derivate of gamma-aminobutyric acid (GABA) and by general anesthetics with suspected GABA-mimetic effects. J Pharmacol Exp Ther 215:418–425

    PubMed  CAS  Google Scholar 

  99. Lalley PM (1983) Biphasic effects of baclofen on phrenic motoneurons: possible involvement of two types of gamma-aminobutyric acid (GABA) receptors. J Pharmacol Exp Ther 226:616–624

    PubMed  CAS  Google Scholar 

  100. Lalley PM (1986) Effects of baclofen and gamma-aminobutyric acid on different types of medullary respiratory neurons. Brain Res 376:392–395

    Article  PubMed  CAS  Google Scholar 

  101. Lang HD, Dürr W, Hoffmann J, Koeth R (1980) Post-clinical follow-up of spinal patients through domestic check-ups. Paraplegia 18:140–144

    Article  PubMed  CAS  Google Scholar 

  102. Lanz E, Däubler F, Eissner D, Brod KH, Theiß D (1986) Der Einfluß der spinalen Liquordynamik auf die subarachnoidale Ausbreitung rückenmarksnah applizierter Substanzen. Reg Anaesth 9:4–8

    PubMed  CAS  Google Scholar 

  103. Levine IM, Jossmann PB, DeAngelis V (1972) Quantitative Wirkungsbeurteilung von CIBA 34 647 Ba. Ein vorläufiger Bericht. In: Birkmayer W (ed) Aspekte der pp 50–70

    Google Scholar 

  104. Levy RA, Proudfit HK (1977) The analgesic action of baclofen. J Pharmacol Exp Ther 202:437–442

    PubMed  CAS  Google Scholar 

  105. Lipscomb DJ, Meredith TJ (1980) Baclofen overdose. Postgrad Med J 56:108–109

    Article  PubMed  CAS  Google Scholar 

  106. Lloyd KG, Bartholini G, Morselli P (1986) GABA and mood disorders. Raven Press, New York

    Google Scholar 

  107. Lloyd KG, Pilc A (1984) Chronic antidepressants and GABA synapses. Neuropharmacology 23:841–842

    Article  CAS  Google Scholar 

  108. Löscher W (1982) Comparative assay of anticonvulsant and toxic potencies of sixteen GABAmimetic drugs. Neuropharmacology 21:803–810

    Article  PubMed  Google Scholar 

  109. Lowitzsch K, D’Amato P, Krämer G (1981) Wirkung von Lioresal auf Kontraktion und isometrische Kraft der quergestreiften Muskulatur. In: Bauer HJ, Koella WP, Struppler A (eds) Therapie der Spastik. Verlag für angewandte Wissenschaften, München, pp 173–175

    Google Scholar 

  110. Martensson A, Knutsson E (1981) Effects of baclofen on different components in the disorganized motor control in spastic paresis. In: Bauer HJ, Koella WP, Struppler A (eds) Therapie der Spastik. Verlag für angewandte Wissenschaften, München, pp 193–199

    Google Scholar 

  111. Matthews PBC (1959) The dependence of tension upon extension in the stretch reflex of the soleus muscle in the decerebrate cat. J Physiol (Lond) 147:521–546

    CAS  Google Scholar 

  112. Matthews WB (1966) Ratio of maximum H reflex to maximum M response as a measure of spasticity. J Neurol Neurosurg Psychiatry 29:201–204

    Article  PubMed  CAS  Google Scholar 

  113. May CR (1983) Baclofen overdose. Ann Emerg Med 12:171–173

    Article  PubMed  CAS  Google Scholar 

  114. McDowell FH (1981) Treatment of spasticity. Drugs 22:401–408

    Article  PubMed  CAS  Google Scholar 

  115. McLellan DL, Selwyn M, Cooper IS (1978) Time course of clinical and physiological effects of stimulation of the cerebellar surface in patients with spasticity. J Neurol Neurosurg Psychiatry 41:150–160

    Article  PubMed  CAS  Google Scholar 

  116. Meldrum B (1984) GABAergic agents as anticonvulsants in baboons with photosensitive epilepsy. Neurosci Lett 47:345–349

    Article  PubMed  CAS  Google Scholar 

  117. Michel M (1983) Rehabilitationsverlauf nach Schädelhirntrauma bei Kindern — eine neurophysiologische Studie. Rehabilitation 22:137–148

    PubMed  CAS  Google Scholar 

  118. Milhorat TH (1975) The third circulation revisited. J Neurosurg 42:628–635

    Article  PubMed  CAS  Google Scholar 

  119. Misgeld U, Klee MR, Zeise ML (1981) Baclofen blockiert die GABAerge Hemmung im Hippocampus. In: Bauer HJ, Koella WP, Struppler A (eds) Therapie der Spastik. Verlag für angewandte Wissenschaften, München, pp 111–114

    Google Scholar 

  120. Morselli P, Lloyd KG (1986) Epilepsy and GABA receptor agonists: Basic and clinical research. Raven Press, New York

    Google Scholar 

  121. Müller H, Vogelberger W, Aigner K, Herget HF, Hempelmann G (1983) Kontinuierliche peridurale Opiatapplikation mit einer implantierten Pumpe. Implantationstechnik und erste Ergebnisse. Reg Anaesth (Anaesthesist) 6:47–51

    Google Scholar 

  122. Neuhäuser G (1975) Methods of assessing and recording motor skills and movement patterns. Dev Med Child Neurol 17:369–386

    Article  PubMed  Google Scholar 

  123. Noth J, Friedemann HH (1984) Die Analyse langlatenziger Dehnungsreflexe zur Erkennung spastischer Syndrome. In: Conrad B, Benecke R, Bauer HJ (eds) Die klinische Wertung der Spastizität. Schattauer, Stuttgart, New York, pp 113–121

    Google Scholar 

  124. Olpe HR, Baudry M, Fagni L, Lynch G (1982) The blocking action of baclofen on excitatory transmission in the rat hippocampal slice. J Neurosci 2:698–703

    PubMed  CAS  Google Scholar 

  125. Olpe HR, Demiéville H, Baltzer H, Bencze WL, Koella WP, Wolf P, Haas HL (1978) The biological activity of d-and l-baclofen. Eur J Pharmacol 52:133–136

    Article  PubMed  CAS  Google Scholar 

  126. Olsen PZ, Diamantopoulos E (1967) Excitability of spinal motor neurones in normal subjects and patients with spasticity, Parkinsonian rigidity and cerebellar hypotonia. J Neurol Neurosurg Psychiatry 30:325–331

    Article  PubMed  CAS  Google Scholar 

  127. Otsuka M, Yanagisawa M (1980) The effect of substance P and baclofen on motorneurons of isolated spinal cord of the newborn rat. J Exp Biol 89:201–214

    PubMed  CAS  Google Scholar 

  128. Panerai AE, Massei R, De Silva E, Sacerdote P, Monza G, Mantegazza P (1985) Baclofen prolongs the analgesic effect of fentanyl in man. Br J Anaesth 57:954–955

    Article  PubMed  CAS  Google Scholar 

  129. Paulson GW (1976) Overdose of Lioresal. Neurology 26:1105–1106

    PubMed  CAS  Google Scholar 

  130. Pedersen E, Arlien-Soborg P, Grynderup V (1970) GABA derivate in spasticity. Acta Neurol Scand 46:257–266

    Article  PubMed  CAS  Google Scholar 

  131. Pedersen A, Arlien-Soborg P, Mai P (1974) The mode of action of the GABA derivate baclofen in human spasticity. Acta Neurol Scand 50:665–680

    Article  PubMed  CAS  Google Scholar 

  132. Penn RD, Paice JA, Gottschalk W, Ivankovich AD (1984) Cancer pain relief using chronic morphine infusion. Early experience with a programmable implanted drug pump. J Neurosurg 61:302–306

    Article  PubMed  CAS  Google Scholar 

  133. Persson B, Henning M (1980) Central cardiovascular and biochemical effects of baclofen in the conscious rat. J Pharm Pharmacol 32:417–422

    Article  PubMed  CAS  Google Scholar 

  134. Piercy M, Hollister RP (1979) Effects of intravenous baclofen on dorsal horn neurons in spinal cat. Eur J Pharmacol 53:379–382

    Article  Google Scholar 

  135. Pinto ODS, Polikar M, Debono G (1972) Results of international clinical trials with Lioresal. Postgrad Med J 48:18–23

    Google Scholar 

  136. Polacek L, Schuppien W (1972) Vier Jahre in der Behandlung der multiplen Sklerose mit Lioresal. In: Birkmayer W (ed) Aspekte der Muskelspastik. Huber, Bern Stuttgart Wien, pp 123–127

    Google Scholar 

  137. Potashner SJ (1978) Baclofen: effects on aminoacid release. Can J Physiol Pharmacol 56:150–156

    Article  PubMed  CAS  Google Scholar 

  138. Prosiegel M, Neu I, Pfaffenrath V, Nahme M (1982) Thrombozytenaggregation und Multiple Sklerose. Nervenarzt 53:227–230

    PubMed  CAS  Google Scholar 

  139. Roberts E, Chase TN, Tower DB (1976) GABA in nervous system function. Raven Press, New York

    Google Scholar 

  140. Roberts E, Frankel S (1950) γ-aminobutyric acid in the brain. Fed Proc 9:219

    Google Scholar 

  141. Sachais BA, Logue JN, Carey MS (1977) Baclofen, a new antispastic drug. Arch Neurol 34:422–428

    Article  PubMed  CAS  Google Scholar 

  142. Saito K, Konishi S, Otsuko M (1975) Antagonism between Lioresal and substance P in the rat spinal cord. Brain Res 97:177–182

    Article  PubMed  CAS  Google Scholar 

  143. Sawa GM, Paty DW (1979) The use of baclofen in treatment of spasticity in multiple sclerosis. Can J Neurol Sci 6:351–356

    PubMed  CAS  Google Scholar 

  144. Sawynok J (1986) Baclofen activates two distinct receptors in the rat spinal cord and guinea pig ileum. Neuropharmacology 25: 795–798

    Article  PubMed  CAS  Google Scholar 

  145. Sawynok J, Dickson C (1984) D-Baclofen: Is it an antagonist at baclofen receptors? Prog Neuropsychopharmacol Biol Psychiatry 8:729–731

    Article  PubMed  CAS  Google Scholar 

  146. Sawynok J, Dickson C (1985) D-Baclofen is an antagonist at Baclofen receptors mediating antinociception in the spinal cord. Pharmacology 31:248–259

    Article  PubMed  CAS  Google Scholar 

  147. Sawynok J, Dickson C (1985) Evidence for the involvement of descending noradrenergic pathways in the antinociceptive effect of baclofen. Brain Res 335:89–97

    Article  PubMed  CAS  Google Scholar 

  148. Sawynok J, Reid A (1986) Clonidine reverses baclofen-induced increases in noradrenaline turnover in rat brain. Neurochem Res 11:723–731

    Article  PubMed  CAS  Google Scholar 

  149. Schepelmann F (1974) Dissociation of motoricity in cerebral lesions. In: Umbach W, Koepchen P (eds) Central-rhythmic and regulation. Hippokrates, Stuttgart, pp 295–301

    Google Scholar 

  150. Schepelmann F (1975) The treatment of spasticity by Foerster’s operation. In: Klug W, Brock M, Klinger M, Spoerri O (eds) Meningiomas-Multiple sclerosis-Forensic problems in neurosurgery. Springer, Berlin Heidelberg New York, pp 417–419

    Google Scholar 

  151. Schepelmann F (1979) Rhythmic patterns of motor activity after lesions of the central nervous system in man. Acta Neurochir (Wien) 49:153–189

    Article  CAS  Google Scholar 

  152. Schepelmann F (1976) Human motor activity in decerebrate states and their sequelae. Acta Neurochir (Wien) 46:185–217

    Article  Google Scholar 

  153. Seyfert S, Straschill M (1982) Elektroenzephalographische Veränderungen unter Baclofen. Z Elektroenzeph Elektromyogr 13:161–166

    CAS  Google Scholar 

  154. Sill JC, Schumacher K, Southorn K, Reuter J, Yaksh TL (1986) Bradycardia and hypotension associated with baclofen used during general anesthesia. Anesthesiology 64:255–258

    Article  PubMed  CAS  Google Scholar 

  155. Sindou M, Millet MF, Moretiemais J, Eysette M (1981) Results of selective posterior rhizotomy in the treatment of painful and spastic paraplegia secondary to multiple sclerosis. Appl Neurophysiol 45:335–340

    Google Scholar 

  156. Smith DF (1984) Stereoselectivity of spinal neurotransmission: effects of baclofen enantiomer on tail-flick reflex in rats. J Neural Transm 60:63–67

    Article  PubMed  CAS  Google Scholar 

  157. Smolenski C, Muff S, Smolenski-Kautz S (1981) A double-blind comparative trial of a new muscle relaxant, tizanidine (DS 103-284) and baclofen in the treatment of chronic spasticity in multiple sclerosis. Curr Med Res Opin 7:374–383

    PubMed  CAS  Google Scholar 

  158. Steardo L, Leo A, Marano E (1984) Efficacy of baclofen in trigeminal neuralgia and some other painful conditions. Eur Neurol 23:51–55

    Article  PubMed  CAS  Google Scholar 

  159. Struppler A (1981) Klinik und Physiologie der Spastik. In: Bauer HJ, Koella WP, Struppler A (eds) Therapie der Spastik. Verlag für angewandte Wissenschaften, München, pp 115–124

    Google Scholar 

  160. Swartzwelder HS, Bragdon AC, Sutch CP, Ault B, Wilson WA (1986) Baclofen suppresses hippocampal epileptiform activity at low concentrations without suppressing synaptic transmission. J Pharmacol Exp Ther 237:881–887

    PubMed  CAS  Google Scholar 

  161. Terrence CF, Fromm GH (1981) Complications of baclofen withdrawal. Arch Neurol 38:588–589

    Article  PubMed  CAS  Google Scholar 

  162. Terrence CF, Fromm GH, Roussan MS (1983) Baclofen: Its effect on seizure frequency. Arch Neurol 40:28–29

    Article  PubMed  CAS  Google Scholar 

  163. Warren SA, Warren KG (1981) Multiple sclerosis and related diseases: a relationship to diabetes mellitus. Can J Neurol Sci 8:35–39

    PubMed  CAS  Google Scholar 

  164. Wesendanger M (1967) Morphological, electrophysiological and pathological aspects of interneurones: In: Widén L (ed) Recent advances in clinical neurophysiology. Elsevier, Amsterdam, pp 47–58

    Google Scholar 

  165. Williford DJ, DiMicco JA, Gillis RA (1980) Evidence for the presence of a tonically active forebrain GABAsystem influencing central sympathetic outflow in the cat. Neuropharmacology 19:245–250

    Article  PubMed  CAS  Google Scholar 

  166. Wilson PR, Yaksh TL (1978) Baclofen is antinociceptive in the spinal intrathecal space of animals. Eur J Pharmacol 51:323–330

    Article  PubMed  CAS  Google Scholar 

  167. Yaksh TL, Müller H (1982) Spinal opiate analgesia. Experimental and clinical studies. Springer, Berlin Heidelberg New York

    Google Scholar 

  168. Yaksh TL, Reddy SV (1981) Studies in the primate on the analgetic effects associated with intrathecal actions of opiates, alphaadrenergic agonists and baclofen. Anesthesiology 54:451–467

    Article  PubMed  CAS  Google Scholar 

  169. Yamada KA, Norman WP, Hamosh P, Gillis RA (1982) Medullary ventral surface GABA receptors affect respiratory and cardiovascular function. Brain Res 248:71–78

    Article  PubMed  CAS  Google Scholar 

  170. Young RR, Delwaide PJ (1981) Drug therapy: spasticity. N Engl J Med 304:96–99

    Article  PubMed  CAS  Google Scholar 

  171. Zander KJ, Puerner K, Struppler A (1981) Motorische Kontrollmechanismen beim hemispastischen Syndrom. Effekte von Baclofen. In: Bauer HJ, Koella WP, Struppler A (eds) Therapie der Spastik. Verlag für angewandte Wissenschaften, München, pp 149–162

    Google Scholar 

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Müller, H., Zierski, J., Dralle, D., Hoffmann, O., Michaelis, G. (1988). Intrathecal Baclofen in Spasticity. In: Müller, H., Zierski, J., Penn, R.D. (eds) Local-spinal Therapy of Spasticity. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72954-6_15

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