Abstract
The definitional characteristics of CEBs (Sect. 1.3) portray two primary sites of action, the heart and vascular smooth muscle. The acute pharmacologic profile of each CEB reflects actions at both sites. In addition, CEBs can be expected to have other effects related to inhibition of excitation-contraction coupling (e.g. nonvascular smooth muscle) or excitation-secretion coupling. The acute response to CEBs will hemodynamically represent a complex expression of direct (e.g. vasodilator and cardiac) and indirect [e.g. reflex sympathetic activation 565) or inhibition of aldosterone release 566)] effects.
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© 1988 Springer-Verlag Berlin Heidelberg
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Smith, R.D., Wolf, P.S., Regan, J.R., Jolly, S.R. (1988). Preclinical Pharmacology. In: The Emergence of Drugs which Block Calcium Entry. Progress in Clinical Biochemistry and Medicine, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73228-7_4
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DOI: https://doi.org/10.1007/978-3-642-73228-7_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-73230-0
Online ISBN: 978-3-642-73228-7
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