Abstract
Cell surface receptors have been traditionally defined through their specific interaction with purified ligands, but the study of oncogene-coded tyrosine kinases and their proto-oncogene homologs has presented the reciprocal problem — namely, can ligands for putative receptors be identified? The demonstration that the v-erbB oncogene encodes a truncated form of the epidermal growth factor (EGF) receptor (Downward et al. 1984b) provided the first direct evidence that certain oncogene products could be derived from receptor genes, and underscored the possibility that critical alterations in receptor function might directly contribute to neoplasia. Investigators now suspect that other retroviral oncogenes of the tyrosine kinase gene family (v-src, v-abl, v-fes/fps, v-yes, v-fgr, and v-ros), as well as functionally related oncogenes derived from tumor cells (neu, trk, met), could also have arisen from receptor genes. One paradigm involves a member of this gene family, c-fms, which encodes a product related, and possibly identical, to the receptor for the macrophage colony-stimulating factor, CSF-1 (Sherr et al. 1985).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Barbacid M, Lauver AV (1981) Gene products of McDonough feline sarcoma virus have an in vitro-associated protein kinase that phosphorylates tyrosine residues: Lack of detection of this enzymatic activity in vivo. J Virol 40: 812–821
Byrne PV, Guilbert LJ, Stanley ER (1981) Distribution of cells bearing receptors for a colony-stimulating factor (CSF-1) in murine tissues. J Cell Biol 91: 848–853
Coussens L, Van Beveren C, Smith D, Chen E, Mitchell RL, Isacke CM, Verma IM, Ullrich A (1986) Structural alteration of viral homologue of receptor proto-oncogene fms at its carboxyl terminus. Nature 320: 277–280
Das SK, Stanley ER (1982) Structure-function studies of a colony-stimulating factor (CSF-1). J Biol Chem 257: 13679–13684
Downward J, Parker P, Waterfield MD (1984a) Autophosphorylation sites on the epidermal growth factor receptor. Nature 311: 483–485
Downward J, Yarden Y, Mayes E, Scrace G, Totty N, Stockwell P, Ullrich A, Schlessinger J, Waterfield MD (1984b) Close similarity of epidermal growth factor receptor and v-erbB oncogene protein sequences. Nature 307: 521–527
Groffen J, Heisterkamp N, Spurr N, Dana S, Wasmuth JJ, Stephenson JR (1983) Chromosomal localization of the human c-fms oncogene. Nucl Acid Res 11: 6331–6339
Guilbert LJ, Stanley ER (1986) The interaction of 125I-CSF-1 with bone marrow-derived macrophages. J Biol Chem (in press)
Hampe A, Gobet M, Sherr CJ, Galibert F (1984) The nucleotide sequence of the feline retroviral oncogene v-fms shows unexpected homology with oncogenes encoding tyrosine-specific protein kinases. Proc Natl Acad Sci USA 81: 85–89
Huebner K, Isobe M, Croce CM, Golde DW, Kaufman SE, Gasson JC (1985) The human gene encoding GM-CSF is at 5q21-q32, the chromosome region deleted in the 5q anomaly. Science 230: 1282–1285
Jackowski S, Rettenmier CW, Sherr CJ, Rock CO (1986) A guanine nucleotide-dependent phosphatidylinositol-4,5-diphosphate-specific phospholipase C in cells transformed by the v-fms and v-fes oncogenes. J Biol Chem 261:4978–4985
Kawasaki ES, Ladner MB, Wang AM, Van Arsdell J, Warren MK, Coyne MY, Schweickart VL, Lee MT, Wilson KJ, Boosman A, Stanley ER, Ralph P, Mark DF (1985) Molecular cloning of a complementary DNA encoding human macrophage-specific colony-stimulating factor (CSF-1). Science 230: 291–296
LeBeau MM, Westbrook CA, Diaz MO, Larson RA, Rowley JD, Gasson JC, Golde DW, Sherr CJ (1986) Evidence for the involvement of GM-CSF and c-fms in the deletion (5q) in myeloid disorders. Science 231: 984–987
Müller R, Slamon DJ, Adamson ED, Tremblay JM, Muller D, Cline MJ, Verma IM (1983a) Transcription of c-onc genes c-ras ki and c-fms during mouse development. Mol Cell Biol 3: 1062–1069
Müller R, Tremblay JM, Adamson ED, Verma IM (1983b) Tissue and cell type specific expression of two human c-onc genes. Nature 304:454–456
Nienhuis AW, Bunn HF, Turner PH, Gopal TV, Nash WG, O’Brien SJ, Sherr CJ (1985) Expression of the human c-fms proto-oncogene in hematopoietic cells and its deletion in the 5q syndrome. Cell 42:421–428
Rettenmier CW, Chen JH, Roussel MF, Sherr CJ (1985a) The product of the c-fms proto-oncogene: a glycoprotein with associated tyrosine kinase activity. Science 228:320–322
Rettenmier CW, Roussel MF, Quinn CO, Kitchingman GR, Look AT, Sherr CJ (1985b) Transmembrane orientation of glycoproteins encoded by the v-fms oncogene. Cell 40:971–981
Rettenmier CW, Sacca R, Furman WL, Roussel MF, Holt JT, Nienhuis AW, Stanley ER, Sherr CJ (1986) Expression of the human c-fms proto-oncogene product (CSF-1 receptor) on peripheral blood mononuclear cells and choriocarcinoma cell lines. J Clin Invest 77: 1740–1746
Roussel MF, Sherr CJ, Barker PE, Ruddle FH (1983) Molecular cloning of the c-fms locus and its assignment to human chromosome 5. J Virol 48: 770–773
Roussel MF, Rettenmier CW, Look AT, Sherr CJ (1984) Cell surface expression of v-fms-coded glycoproteins is required for transformation. Mol Cell Biol 4: 1999–2009
Sacca R, Stanley ER, Sherr CJ, Rettenmier CW (1986) Specific binding of the mononuclear phagocyte colony stimulating factor, CSF-1, to the product of the v-fms oncogene. Proc Natl Acad Sci USA 83:3331–3335
Sherr CJ, Rettenmier CW, Sacca R, Roussel MF, Look AT, Stanley ER (1985) The c-fms protooncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1. Cell 41: 665–676
Slamon DJ, deKernion JB, Verma IM, Cline MJ (1984) Expression of cellular oncogenes in human malignancies. Science 224: 256–262
Stanley ER, Guilbert LJ, Tushinski RJ, Bartelmez SH (1984) Growth factors regulating mononuclear phagocyte production. In: Volkman A (ed) Mononuclear phagocyte biology. Dekker, New York, pp 373–387
Wheeler EF, Roussel MF, Hampe A, Walker MH, Fried VA, Look AT, Rettenmier CW, Sherr CJ (1986) The amino-terminal domain of the v-fms oncogene product includes a functional signal peptide that directs synthesis of a transforming glycoprotein in the absence of feline leukemia virus gag sequences. J Virol 59: 224–233
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Sherr, C.J., Stanley, E.R. (1986). The c-fms Proto-Oncogene and the CSF-1 Receptor. In: Kahn, P., Graf, T. (eds) Oncogenes and Growth Control. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73325-3_13
Download citation
DOI: https://doi.org/10.1007/978-3-642-73325-3_13
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-18760-8
Online ISBN: 978-3-642-73325-3
eBook Packages: Springer Book Archive