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The Role of Complement in Injury

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Immune Consequences of Trauma, Shock, and Sepsis

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Abstract

Complement is of importance for restricting microorganisms to their normal sites such as skin and gut as well as for clearing the blood stream of these invaders. During evolution organisms had complement for host defense before they were provided with antibodies (Muller-Eberhard 1975). This cascade system can be activated by an antibody fixed to an antigen but also in a more nonspecific way without antibodies. Chemotaxis, opsonization, and lysis of bacteria or injured or foreign cells are influenced by products formed when complement is activated, a process modulated by inhibitors. Hereditary defects leading to reduced amounts of complement from the alternative pathway are associated with repeated and sometimes life-threatening infections (Muller-Eberhard 1978). The same effect can be observed after extensive injuries leading to consumption of complement or after starvation or by prolonged medication with corticosteroids (Alexander et al. 1979; Alexander 1980; Atkinson et al. 1973).

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Authors
  1. M. Heideman
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Editors and Affiliations

  1. Dept. of Surgery, LM University Munich Klinikum Großhadern, Marchioninistr. 15, 8000, Munich 70, Germany

    Eugen Faist

  2. University of California, San Diego, California, 92103, USA

    John L. Ninnemann Ph. D. (Associate Adjunct Professor of Surgery) (Associate Adjunct Professor of Surgery)

  3. University of Alberta Edmonton, Alberta, T6G 2H7, Canada

    Douglas R. Green Ph. D. (Associate Professor of Immunology) (Associate Professor of Immunology)

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© 1989 Springer-Verlag, Berlin Heidelberg

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Heideman, M. (1989). The Role of Complement in Injury. In: Faist, E., Ninnemann, J.L., Green, D.R. (eds) Immune Consequences of Trauma, Shock, and Sepsis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73468-7_26

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  • DOI: https://doi.org/10.1007/978-3-642-73468-7_26

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73470-0

  • Online ISBN: 978-3-642-73468-7

  • eBook Packages: Springer Book Archive

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