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Prostaglandins and Leukotrienes in Monocyte/T Cell Function in Stress and Trauma

  • Conference paper
Immune Consequences of Trauma, Shock, and Sepsis

Abstract

Prostaglandins (PGs) and leukotriene’s (LTs) are products of arachidonic acid metabolism and are produced by many types of mammalian cells. These versatile compounds participate in a variety of normal physiological processes, including the maintenance of blood pressure and body temperature, protection of organs from damage caused by disease, and the regulation of parturition. It is now also clear that the PGs (particularly PGE2) and the LTs (particularly LTB4) are important in the normal regulation of the immune response. Conversely, shifts in the balance of arachidonic acid metabolite production have been implicated in shock, and a wide variety of disease states, including arthritis, malignancy, and the allergic disorders (reviewed by Ninnemann 1988).

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References

  • Anggard E, Arturson G, Jonsson CE (1970) Efflux of prostaglandins in lymph from scalded tissues. Acta Physiol Scand 80: 46A

    Article  PubMed  CAS  Google Scholar 

  • Bach MK (1983) The leukotrienes; their structure, actions, and role in diseases. Current concepts series. Upjohn, Kalamazoo

    Google Scholar 

  • Bankhurst AD, Hastain E, Goodwin JS, Peake GT (1981) The nature of the prostaglandin-producing mononuclear cell in human peripheral blood. J Lab Clin Med 97: 179–186

    PubMed  CAS  Google Scholar 

  • Bockman RS (1979) PGE inhibition of T lymphocyte colony formation. J Clin Invest 64: 812–821

    Article  PubMed  CAS  Google Scholar 

  • Bonta IL, Parnham MJ (1982) Immunomodulatory-antiinflammatory functions of E-type prostaglandins. Minireview with emphasis on macrophage mediated effects. Int J Immunopharmacol 4: 103–109

    Article  PubMed  CAS  Google Scholar 

  • Chouaib S, Chatenoud L, Klatzmann D, Fradelizi D (1984) The mechanism of inhibition of human IL-2 production. II. PGE2 induction of suppressor T lymphocytes. J Immunol 132: 1851–1857

    PubMed  CAS  Google Scholar 

  • Darrow TL, Tomar RH (1980) Prostaglandin-mediated regulation of the mixed lymphocyte culture and generation of cytotoxic cells. Cell Immunol 65: 172–178

    Article  Google Scholar 

  • Enteu U, Enre T, Cavdar AO, Turker RK (1980) An in vitro study on the effect of prostaglandin E2 and F2 alpha on E-rosette forming activity of normal lymphocytes. Prostaglandins Leukotrienes Med 5: 255–261

    Google Scholar 

  • Faist E, Kupper TS, Baker CC, Chaudry IH, Dwyer J, Baue AE (1986) Depression of cellular immunity after major injury. Arch Surg 121: 1000–1005

    Article  PubMed  CAS  Google Scholar 

  • Fischer A, Durandy A, Griscelli C (1981) Role of prostaglandin E2 in the induction of nonspecific T lymphocyte suppressor activity. J Immunol 126: 1452

    PubMed  CAS  Google Scholar 

  • Goldyne ME, Stobo JD (1979) Synthesis of prostaglandins by subpopulations of human peripheral blood monocytes. Prostaglandins 18: 687–695

    Article  PubMed  CAS  Google Scholar 

  • Goodman MG, Weigle WO (1980) Modulation of lymphocyte activation. I. Inhibition by an oxidation product of arachidonic acid. J Immunol 125: 593–600

    PubMed  CAS  Google Scholar 

  • Goodwin JS, Messner RP, Peake GT (1978) Prostaglandin suppression of mitogen-stimulated lymphocytes in vitro. J Clin Invest 62: 753–760

    Article  PubMed  CAS  Google Scholar 

  • Goodwin JS, Wiik A, Lewis M, Bankhurst AD, Williams RC (1979) High affinity binding sites for prostaglandin E on human lymphocytes. Cell Immunol 43: 150–159

    Article  PubMed  CAS  Google Scholar 

  • Goodwin JS, Bromberg S, Staszak C, Kaszubowski PA, Messner RP, Neal JF (1981) Effect of physical stress on sensitivity of lymphocytes to inhibition by prostaglandin E2. J Immunol 127: 518–522

    PubMed  CAS  Google Scholar 

  • Gordon D, Bray M, Morley J (1976) Control of lymphokine secretion by prostaglandins. Nature 262: 401–407

    Article  PubMed  CAS  Google Scholar 

  • Gorski A, Graciong Z, Dupont B (1982) Enhanced colonability of human T lymphocytes causes by their culturing in vitro. Immunology 44: 617–622

    Google Scholar 

  • Grbic JT, Wood JJ, Jordan A, Rodrick ML, Mannick J A (1985) Lymphocytes from burned patients are more sensitive to suppression by prostaglandin E2. Surg Forum 108–110

    Google Scholar 

  • Hamberg M, Jonsson CE (1973) Increased synthesis of prostaglandins in guinea pig following scalding injury. 87: 240

    CAS  Google Scholar 

  • Hansbrough J, Petersonn V, Zapata-Sirvent R, Claman HN (1984) Postburn immunosuppression in an animal model. II. Restoration of cell-mediated immunity by immune-modulating drugs. Surgery 95: 290–295

    PubMed  CAS  Google Scholar 

  • Heggers JP, Loy GL, Robson MC, DelBeccaro EJ (1980) Histological demonstration of prostaglandins and thromboxanes in burned tissue. J Surg Res 28: 110–117

    Article  PubMed  CAS  Google Scholar 

  • Humes JL, Bonney RW, Peius L, Dahlgren ME, Sadowski SS, Kuehl FA, Davies P (1977) Macrophages synthesize and release prostaglandins in response to inflammatory stimuli. Nature 269: 159

    Article  Google Scholar 

  • Kaszubowski PA, Goodwin JS (1982) Monocyte-produced prostaglandin induces Fc gamma receptor expression on human T cells. Cell Immunol 68: 343–348

    Article  PubMed  CAS  Google Scholar 

  • Kennedy MS, Stobo JD, Goldyne ME (1980) In vitro synthesis of prostaglandins and related lipids by populations of human peripheral blood mononuclear cells. Prostaglandins 20: 135–145

    Article  PubMed  CAS  Google Scholar 

  • Morley J, Bray MA, Jones RW, Nugteren DH, VanDorp DA (1979) Prostaglandins and thromboxanes production by human and guinea pig macrophages and leukocytes. Prostaglandins 17: 729–736

    Article  PubMed  CAS  Google Scholar 

  • Neill MA, Henderson WR, Klebanoff SJ (1985) Oxidative degradation of leukotriene C4 by human monocytes and monocyte-derived macrophages. J Exp Med 162: 1634–1644

    Article  PubMed  CAS  Google Scholar 

  • Ninnemann JL (1987) PGE regulates lymphocyte stimulation by I1–2. Proc Am Burn Assoc 19: 10

    Google Scholar 

  • Ninnemann JL (1988) Prostaglandins, leukotrienes, and the immune response. Cambridge University Press, New York

    Book  Google Scholar 

  • Ninnemann JL, Stockland AE (1984) Participation of prostaglandin E in immunosuppression following thermal injury. J Trauma 24: 201–207

    Article  PubMed  CAS  Google Scholar 

  • Oates JA, Roberts LD, Sweetman BJ, Maas RL, Gerkens JF, Tabber DF (1980) Metabolism of the prostaglandins and thromboxanes. Adv Prostaglandin Thromboxane Leukotriene Res 6: 35–41

    CAS  Google Scholar 

  • Oropeza-Rendon RL, Bauer HC, Fischer H (1980) Effect of prostaglandin El on the level of cAMP in bone marrow macrophages. Inhibition of phagocytosis and cell shape changes. J Immunopharmacol 2: 133–147

    Article  PubMed  CAS  Google Scholar 

  • Payan DG, Goetzl EJ (1983) Specific suppression of human T lymphocyte function by leukotriene B4. J Immunol 131: 551–553

    PubMed  CAS  Google Scholar 

  • Rappaport RS, Dodge GR (1982) Prostaglandin E inhibits the production of human interleukin 2. J Exp Med 155: 943–948

    Article  PubMed  CAS  Google Scholar 

  • Rodrick ML, Saporoschetz IB, Wood JJ, Davis CF, Mannick JA (1985) Serum suppression of interleukin-2 (IL-2) production and IL-2 action in thermal injury. Surg Forum 98–99

    Google Scholar 

  • Simkin NJ, Jelinek DF, Lipsky PE (1987) Inhibition of human B cell responsiveness by prostaglandin E2. J Immunol 138: 1074–1081

    PubMed  CAS  Google Scholar 

  • Teodorczyk-Injeyan J, Sparkes BG, Mills GB, Peters WJ, Falk RE (1986) Impairment of T cell activation in burn patients: a possible mechanism of thermal injury-induced immunosuppression. Clin Exp Immunol 65: 570–581

    PubMed  CAS  Google Scholar 

  • Teodorczyk-Injeyan JA, Sparkes BG, Peters WJ, Gerry K, Falls RE (1987) Prostaglandin E-related impaired expression of interleukin 2 receptor in the burn patient. Adv Prostaglandin Thromboxane Leukotriene Res 17: 151–154

    Google Scholar 

  • VanEpps D (1981) Suppression of human lymphocyte migration by PGE2. Inflammation 5: 81–87

    Article  CAS  Google Scholar 

  • Williams JD, Czop JK, Austen KF (1984) Release of leukotrienes by human monocytes on stimulation of their phagocytic receptor for particulate activators. J Immunol 132: 3034–3040

    PubMed  CAS  Google Scholar 

  • Wood JJ, Rodrick ML, Grbic JT, Mannick JA (1986) Suppression of interleukin-2 (IL-2) production in an animal model of thermal injury is related to prostaglandin synthesis. Proc Surg Infect Soc: 33

    Google Scholar 

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Authors
  1. J. L. Ninnemann
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Editors and Affiliations

  1. Dept. of Surgery, LM University Munich Klinikum Großhadern, Marchioninistr. 15, 8000, Munich 70, Germany

    Eugen Faist

  2. University of California, San Diego, California, 92103, USA

    John L. Ninnemann Ph. D. (Associate Adjunct Professor of Surgery) (Associate Adjunct Professor of Surgery)

  3. University of Alberta Edmonton, Alberta, T6G 2H7, Canada

    Douglas R. Green Ph. D. (Associate Professor of Immunology) (Associate Professor of Immunology)

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© 1989 Springer-Verlag, Berlin Heidelberg

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Ninnemann, J.L. (1989). Prostaglandins and Leukotrienes in Monocyte/T Cell Function in Stress and Trauma. In: Faist, E., Ninnemann, J.L., Green, D.R. (eds) Immune Consequences of Trauma, Shock, and Sepsis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73468-7_35

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  • DOI: https://doi.org/10.1007/978-3-642-73468-7_35

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73470-0

  • Online ISBN: 978-3-642-73468-7

  • eBook Packages: Springer Book Archive

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