Abstract
Our experimental work in the rodent is concerned with the plasticity of immature cerebral cortex, and more specifically with the effects of focal cerebral lesions in infancy on the organization of the corticospinal motor system. Our interest in this problem derives from certain observations related to focal brain damage and to recovery from it in the human infant. At the outset, we would therefore like to briefly summarize relevant observations in man and point out some of the questions they raise that are not readily answerable by clinical studies, but are amenable to study in the experimental animal.
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References
Adams CE, Mihailoff GA, Woodward DJ (1983) A transient component of the developing corticospinal tract arises in visual cortex. Neurosci Lett 36: 243–248
Basser LS (1962) Hemiplegia of early onset and the faculty of speech with special reference to the effects of hemispherectomy. Brain 85: 427–460
Bates CA, Killackey KP (1984) The emergence of a discretely distributed pattern of corticospinal projection neurons. Dev Brain Res 13: 265–273
Castro AJ (1975) Ipsilateral corticospinal projections after large lesions of the cerebral hemisphere in neonatal rats. Exp Neurol 46: 1–8
D’Amato CJ, Hicks SP (1978) Normal development and posttraumatic plasticity of corticospinal neurons in rats. Exp Neurol 60: 557–569
Goldman PS (1972) Developmental determinants of cortical plasticity. Acta Neurobiol Exp 32: 495–511
Hall RD, Lindholm EP (1974) Organization of motor somatosensory neocortex in the albino rat. Brain Res 66: 23–38
Hicks SP, D’Amato JC (1970) Motor-sensory and visual behavior after hemispherectomy in newborn and mature rats. Exp Neurol 29: 416–438
Kiessling LS, Denckla MB, Carlton M (1983) Evidence for differential hemispheric function in children with hemiplegic cerebral palsy. Dev Med Child Neurol 25: 727–734
Kennard MA (1940) Relation of age to motor impairment in man and in subhuman primates. AMA Arch Neurol Psychiatry 48: 227–240
Leong SK, Lund R (1973) Anomalous bilateral corticofugal pathways in albino rats after neonatal lesions. Brain Res 62: 218–221
Leong SK, Lund R (1976) An experimental study of the corticofugal system following cerebral lesions in the albino rat. Exp Brain Res 26: 235–247
Levine SC, Huttenlocher PR, Banich MT, Duda E (1987) Factors affecting cognitive functioning in hemiplegic children. Dev Med Child Neurol 29: 27–35
Olmos J de, Hardy H, Heimer L (1978) The afferent connections of the main and accessory olfactory bulb formation in the rat: an experimental HRP study. J Comp Neurol 181: 213–244
Reinoso BS, Castro AJ (1985) Analysis of corticospinal plasticity using retrograde fluorescent tracers in rats. Soc Neurosci Abstr 11: 1286
Rye DB, Saper CB, Wainer BH (1984) Stabilization of the tetramethylbenzidine ( TMB) reaction product. J Histochem Cytochem 32: 1145–1153
Sharp FR, Evans KL (1983) Bilateral C14 2-deoxyglucose uptake by motor pathways after unilateral neonatal cortex lesions in the rat. Dev Brain Res 6: 1–11
Sloper J, Brodal P, Powell TPS (1983) An anatomical study of the effects of unilateral removal of sensorimotor cortex in infant monkeys on the subcortical projections of the contralateral sensorimotor cortex. Brain 106: 707–716
St James-Roberts I (1981) A reinterpretation of hemispherectomy data without functional plasticity of the brain. Brain Language 13: 31–53
Stanfield BB, O’Leary DDM (1985) The transient corticospinal projection from the occipital cortex during the postnatal development of the rat. J Comp Neurol 238: 236–248
Ueki K (1966) Hemispherectomy in the human with special reference to the preservation of function. Prog Brain Res 21: 285–338
Vargha-Khadem F, O’Gorman AM, Watters GV (1985) Aphasia and handedness in relation to hemispheric side, age at injury and severity of cerebral lesion during childhood. Brain 108: 677–696
Westphal C (1874) Über einige Bewegungs-Erscheinungen an gelähmten Gliedern. Arch Psychiatr 4: 747–759
Wilson PJE (1970) Cerebral hemispherectomy for infantile hemiplegia: a report of 50 cases. Brain 93: 147–180
Wise SP, Murray EA, Coulter JD (1979) Somatotopic organization of corticospinal and corticotrigeminal neurons in the rat. Neuroscience 4: 65–78
Woods BT, Teuber H-L (1979 a) Changing patterns of childhood aphasia. Ann Neurol 3: 273–280
Woods BT, Teuber H-L (1978 b) Mirror movements after childhood hemiparesis. Neurology 28: 1152–1158
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© 1988 Springer-Verlag Berlin Heidelberg
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Huttenlocher, P.R., Raichelson, R. (1988). Post-Lesion Neural Plasticity in Cerebral Cortex: the Response of Rat Sensorimotor Cortex to Neonatal Ablation of the Opposite Hemisphere. In: Flohr, H. (eds) Post-Lesion Neural Plasticity. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73849-4_16
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DOI: https://doi.org/10.1007/978-3-642-73849-4_16
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