Abstract
Chronic monocular deafferentation has been shown to produce an increased excitability in cells of the dorsal lateral geniculate nucleus (dLGN) (Eysel 1979). Furthermore, a recent quantitative morphological study (Somogyi et al. 1987) has shown that chronic monocular deafferentation results in a relative increase in density of the excitatory cortical input to the dLGN neuron. This effect and the changes related to transneural atrophy of the deafferented cells might explain part of the functional changes observed after chronic deafferentation. Nevertheless, denervation supersensitivity might also be involved. Accumulating evidence indicates that the neural transmitter mediating the visual input to dLGN cells acts at an excitatory amino acid receptor (Kemp and Sillito 1982). Natural excitatory amino acids such as L-glutamate and L-aspartate can act at a number of receptors which have been characterized in terms of the specific agonists N-methyl-D-aspartate, quisqualate and kainate (Watkins and Evans 1981). In the present experiments we have addressed the question of possible denervation supersensitivity to excitatory amino acid agonists as a consequence of chronic monocular deafferentation. With the iontophoretic technique the responses of normal and denervated cells in the A-laminae of the dLGN to acetylcholine, N-methyl-D-aspartate and quisqualate were compared. The results indicate that chronic monocular deafferentation increases the relative sensitivity of the denervated cells to quisqualate.
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References
Baughman RW, Gilbert CD (1981) Aspartate and glutamate as possible neurotransmitters in the visual cortex. J Neurosci 1: 427–439
Bird SJ, Aghajanian GJ (1975) Denervation supersensitivity in the cholinergic septohippocampal pathway: a microiontophoretic study. Brain Res 100: 355–370
Cannon WB, Haimovici H (1939) The sensitization of motoneurones by partial “denervation”. Am J Physiol 126: 731–740
Eysel UT (1979) Maintained activity, excitation and inhibition of lateral geniculate neurons after monocular deafferentation in the adult cat. Brain Res 166: 259–271
Eysel UT, Pape H (1987) Lateral excitation in the cat lateral geniculate nucleus. Exp Brain Res 67: 291–298
Eysel UT, Wolfhard U (1984) The effects of partial retinal lesions on activity and size of cells in the dorsal lateral geniculate nucleus. J Comp Neurol 229: 301–309
Eysel UT, Pape H-C, Schayck R van (1986) Excitatory and differential disinhibitory actions of acetylcholine in the lateral geniculate nucleus of the cat. J Physiol 370: 233–254
Guillery RW (1971) Patterns of synaptic interconnections in the dorsal lateral geniculate nucleus of the cat and monkey: a brief review. Vision Res Suppl 3: 211–227
Kemp JA, Sillito AM (1982) The nature of the excitatory transmitter mediating X and Y cell inputs to the cat dorsal lateral geniculate nucleus. J Physiol 323: 377–391
Kjerulf TD, Loeser JD (1973) Neuronal hyperactivity following deafferentation of the lateral cuneate nucleus. Exp Neurol 39: 70–85
Lamour Y, Dutar P, Jobert A (1982) Excitatory effect of acetylcholine on different types of neurones in the first somatosensory neocortex of the rat: laminar distribution and pharmacological characteristics. Neuroscience 10: 107–117
Lima AD de, Singer W (1987) The brain stem projection to the lateral geniculate nucleus in the cat. Identification of cholinergic and monaminergic terminals. J Comp Neurol 259: 92–121
McCall RB, Aghajanian GK (1979) Denervation supersensitivity to serotonin in the facial nu-cleus. Neuroscience 4: 1501–1510
McCough GP, Austin GM, Liu CN, Liu CY (1958) Sprouting as a cause of spasticity. J Neurophysiol 21: 205–216
Menkes DB, Gallagher DW, Reinhard JF, Aghajanian GK (1983) ocx-Adrenoceptor supersensitivity in brain: physiological and receptor binding studies. Brain Res 272: 1–12
Pape H-C, Eysel UT (1988) Cholinergic excitation and inhibition in the visual thalamus of the cat - influences of cortical inactivation and barbiturate anesthesia. Brain Res 440: 79–86
Salt TE (1986) Mediation of thalamic sensory input by both NMD A receptors and non-NMDA receptors. Nature 322: 263–265
Sillito AM, Kemp J A, Berardi N (1983) The cholinergic influence on the function of the cat dorsal lateral geniculate nucleus (dLGN) Brain Res 280: 299–307
Somogyi J, Eysel UT, Hamori J (1987) A quantitative study of morphological reorganization following chronic optic deafferentation in the adult cat dorsal lateral geniculate nucleus. J Comp Neurol 255: 341–350
Watkins JC, Evans RH (1981) Excitatory amino acid transmitters. Annu Rev Pharmacol 21: 165–204
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© 1988 Springer-Verlag Berlin Heidelberg
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Eysel, U.T., Pape, HC., Salt, T., Sillito, A. (1988). Lesion-Induced Relative Supersensitivity to an Excitatory Amino Acid Agonist in the Cat Dorsal Lateral Geniculate Nucleus. In: Flohr, H. (eds) Post-Lesion Neural Plasticity. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73849-4_42
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DOI: https://doi.org/10.1007/978-3-642-73849-4_42
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