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The Hemolytic Uremic Syndromes

  • Conference paper
Ergebnisse der Inneren Medizin und Kinderheilkunde / Advances in Internal Medicine and Pediatrics

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Abstract

This paper is about a number of disorders occurring in children and adults that, although they have different etiologies and variable clinical expression, share three constant features: acquired hemolytic anemia, thrombocytopenia and renal damage, and one common histological lesion mostly referred to as thrombotic microangiopathy, a term introduced by Symmers in 1952.

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References

  • Adelson E, Heitzmann EJ, Fennessey JF (1954) Thrombohemolytic thrombocytopenic purpura. Arch Intern Med 94: 42–60

    CAS  Google Scholar 

  • Amorosi EL, Karpatkin J (1977) Antiplatelet treatment of thrombotic thrombocytopenic purpura. Ann Intern Med 86: 102–108

    PubMed  CAS  Google Scholar 

  • Amorosi EL, Ullman JE (1966) Thrombotic thrombocytopenic purpura: report of 16 cases and review of the literature. Medicine 45: 139–159

    Google Scholar 

  • Andreoli SP, Bergstein JM (1982) Development of insulin-dependent diabetes mellitus during hemolytic uremic syndrome. J Pediatr 100: 541–545

    PubMed  CAS  Google Scholar 

  • Anthony PP, Kaplan AB (1968) Fatal hemolytic uraemic syndrome in two sibs. Arch Dis Child 43: 316–318

    PubMed  CAS  Google Scholar 

  • Antman KH, Skarin AT, Mayer RJ, Hargreaves HK, Canellos GP (1979) Microangiopathic hemolytic anemia and cancer. A review. Medicine 58: 377–384

    CAS  Google Scholar 

  • Arenson EB, August CS (1975) Treatment of the hemolytic uremic syndrome with aspirin and dipyiidamole. J Pediatr 86: 961–975

    Google Scholar 

  • Ashouri OS, Marbury TC, Fuller TJ, Gaffney E, Grubb WG, Cade JR (1982) Hemolytic uremic syndrome in two postmenopausal women taking a conjugated estrogen preparation. Clin Nephrol 17: 212–214

    PubMed  CAS  Google Scholar 

  • Baker NM, Mills AE, Rachman I, Thomas JEP (1974) Haemolytic uraemic syndrome in typhoid fever. Br Med J 2: 84–87

    PubMed  CAS  Google Scholar 

  • Bale JF, Brasher C, Siegler RL (1980) CNS manifestations of the hemolytic uremic syndrome. Am J Dis Child 134: 869–872

    PubMed  Google Scholar 

  • Barre P, Kaplan BS, de Chadarevian J-P, Drummond KN (1977) Hemolytic uremic syndrome with hypocomplementemia, serum C3NeF and glomerular deposits of C3. Arch Pathol Lab Med 101: 357–361

    PubMed  CAS  Google Scholar 

  • Bar-Ziv J, Ayoub JIG, Fletcher BD (1974) Hemolytic-uremic syndrome: a case presenting with acute colitis. Pediatr Radiol 2: 203–206

    PubMed  CAS  Google Scholar 

  • Beattie TJ, Murphy AV, Willoughby MLN (1981a) Prostacyclin infusion in haemolytic uraemic syndrome of children. Br Med J 283: 470

    CAS  Google Scholar 

  • Beattie TJ, Murphy AV, Willoughby MLN, Machin SJ, Defreyn G (198lb) Plasmapheresis in the haemolytic uraemic syndrome in children. Br Med J 282: 1667–1668

    Google Scholar 

  • Beck JS (1958) Acute radiation nephritis in childhood. Br Med J 2: 489–490

    PubMed  CAS  Google Scholar 

  • Berberich FR, Cuene SA, Chard RL, Hartmann JR (1974) Thrombotic thrombocytopenic purpura. Three cases with platelet and fibrinogen survival times. J Pediatr 84: 503–509

    PubMed  CAS  Google Scholar 

  • Bergstein J, Michael AF, Kjellstand C (1974) Hemolytic-uremic syndrome in adult sisters. Transplantation 17: 487–490

    PubMed  CAS  Google Scholar 

  • Bergstein JM, Kuederli U, Bang NU (1982) Plasma inhibitor of glomerular fibrinolysis in the hemolytic uremic syndrome. Am J Med 73: 322–327

    PubMed  CAS  Google Scholar 

  • Berman N, Finkelstein JZ (1975) Thrombotic thrombocytopenic purpura in childhood. Scand J Haematol 14: 286–294

    PubMed  CAS  Google Scholar 

  • Best LC, Martin TJ, McGuire MB, Preston FE, Russell RGG, Segal DS (1978) Dipyridamole and platelet function. Lancet 11: 846

    Google Scholar 

  • Binda ki Muaka P (1982) Syndrome hémolytique et urémique chez l’enfant. Traitement par des antithrombotiques. Thesis, University of Leuven

    Google Scholar 

  • Binda ki Muaka P, Proesmans W, Eeckels R (1981) The haemolytic uraemic syndrome in childhood: a study of the long term prognosis. Eur J Pediatr 136: 237–243

    Google Scholar 

  • Blättler W, Wegmann W, Herold H, Straub PW (1975) Familiäres hämolytisch urämisches Syndrom. Schweiz Med Wochenschr 105: 1173–1774

    Google Scholar 

  • Bohle A, Heimchen U, Grund KE, Gärtner HV, Meyer D, Bock KD, Bulla M, Bünger P, Diekmann L, Frotscher U, Hayduk K, Kösters W, Strauch M, Scheler F, Christ H (1977) Malignant nephrosclerosis in patient with hemoyltic uremic syndrome (primary malignant nephrosclerosis). Curr Top Pathol 65: 81–113

    PubMed  CAS  Google Scholar 

  • Bos AP, Donckerwolcke RA, Van Vugt AJ (1985) The hemolytic uremic syndrome: prognostic significance of neurological abnormalities. Heiv Paediatr Acta 40: 386–389

    Google Scholar 

  • Brain MC, Dacie JV, O’Hourihane JV (1962) Microangiopathic haemolytic anaemia: the possible role of vascular lesions in pathogenesis. Br J Haemat 8: 358–374

    CAS  Google Scholar 

  • Brandt P, Jespersen J, Gregersen G (1981) Postpartum haemolytic uraemic syndrome treated with antithrombin III. Nephron 27: 15–18

    PubMed  CAS  Google Scholar 

  • Brown CB, Clarkson AR, Robson JC, Cameron JS, Thomson D, Ogg CS (1973) Haemolytic uraemic syndrome in women taking oral contraceptives. Lancet 1: 1479–1481

    PubMed  CAS  Google Scholar 

  • Budd GT, Bukowski RM, Lucas EV, Cato AE, Cochetto DM (1980) Prostacy clin therapy in thrombotic thrombocytopenic purpura. Lancet 11: 915

    Google Scholar 

  • Bukowski RM, King JW, Hewlett JS (1977) Plasm apheresis in the treatment of thrombotic thrombocytopenic purpura. Blood 50: 413–417

    PubMed  CAS  Google Scholar 

  • Burn JC, Berman ER, Fagre JL, Shikes RH, Lum GM (1982) Pancreatic islet cell necrosis associated with hemolytic uremic syndrome. J Pediatr 100: 582–584

    Google Scholar 

  • Byrnes JJ, Khurana M (1977) Treatment of thrombotic thrombocytopenic purpura with plasma. N Engl J Med 297: 1386–1389

    PubMed  CAS  Google Scholar 

  • Byrnes JJ, Moake JL (1986) Thrombotic thrombocytopenic purpura and the haemolytic uraemic syndrome: evolving concepts of pathogenesis and therapy. Clin Haematol 15: 413–442

    PubMed  CAS  Google Scholar 

  • Cameron JS, Vick R (1973) Plasma C3 in haemolytic uraemic syndrome and thrombotic thrombocytogenic purpura. Lancet 11: 975

    Google Scholar 

  • Campbell S, Carré IJ (1965) Fatal haemolytic uraemic syndrome and idiopathic hyperlipidaemia in monozygotic twins. Arch Dis Child 40: 654–658

    PubMed  CAS  Google Scholar 

  • Chamone DA, Proesmans WC, Monnens LA, Binda ki Muaka P, Vermylen JC (1982) Reversible deficient prostacyclin release in childhood hemolytic-uremic syndrome. Int J Pediatr Nephrol 3: 13–16

    PubMed  CAS  Google Scholar 

  • Chu JY, Gleason WA, Mestres HM (1977) Haemolytic uraemic syndrome in dysentery. Lancet 11: 1025–1026

    Google Scholar 

  • Churg J, Koffler D, Paronetto F, Rorat E, Barnett RN (1970) Hemolytic uremic syndrome as a cause of postpartum renal failure. Am J Obstet Gynecol 108: 253–261

    PubMed  CAS  Google Scholar 

  • Clarkson AR, Meadows R, Lawrence JR (1969) Postpartum renal failure. The generalized Schwartzman reaction. Aust Ann Med 18: 209–216

    PubMed  CAS  Google Scholar 

  • Courtecuisse V, Habib R, Monnier C (1967) Non-lethal hemolytic uremic syndromes in children: an electron microscopic study of renal biopsies from six cases. Exp Med Pathol 7: 327–347

    CAS  Google Scholar 

  • Courtecuisse V, Dommergues JP, Rivron J, Chaon P (1975) Syndrome hémolytique et urémique familial avec biopsie rénale normale. Arch Fr Pediatr 32: 749–755

    PubMed  CAS  Google Scholar 

  • Craig JM, Gitlin D (1957) The nature of the hyaline thrombi in thrombotic thrombocytopenic purpura. Am J Pathol 33: 251–265

    PubMed  CAS  Google Scholar 

  • Crocker J, Jones EL (1983) Haemolytic-uremic syndrome complicating long-term mitomycin-C and 5-fluorouracil therapy for gastric carcinoma. J Clin Pathol 36: 24–29

    PubMed  CAS  Google Scholar 

  • Cuttner J (1974) Splenectomy, steroids and dextran 70 in thrombotic thrombocytopenic purpura. JAMA 227: 397–402

    PubMed  CAS  Google Scholar 

  • Deckmyn H, Proesmans W, Vermylen J (1983) Prostacyclin production of whole blood from children: impairment in the hemolytic uremic syndrome and excessive formation in chronic renal failure. Thromb Res 30: 13–18

    PubMed  CAS  Google Scholar 

  • Defreyn G, Proesmans W, Machin JS, Lemmens F, Vermylen J (1982) Abnormal prostacyclin metabolism in the hemolytic uremic syndrome: equivocal effect of prostacyclin infusions. Clin Nephrol 18: 43–49

    PubMed  CAS  Google Scholar 

  • De Jong MC, Monnens LA (1976) Recurrent haemolytic uraemic syndrome. Padiatr Padol 11: 521–527

    PubMed  Google Scholar 

  • Diekmann L (1980) Streptokinase and Heparin-behandlung beim hämolytisch urämischen Syndrom. Klin Padiatr 192: 430–435

    PubMed  CAS  Google Scholar 

  • Dolislager D, Tune B (1978) The hemolytic uremic syndrome. Spectrum of severity and significance of prodromes. Am J Dis Child 132: 55–58

    PubMed  CAS  Google Scholar 

  • Donckerwolcke RA, Kuyten RH, Tiddens HA, Van Gool JD (1979) Haemolytic uraemic syndrome. Pediatrician 8: 378–393

    CAS  Google Scholar 

  • Dosik H, Tricarico F (1970) Haemolytic-uraemic syndrome following mumps vaccination. Lancet 1: 247

    PubMed  CAS  Google Scholar 

  • Drukker A, Winterborn M, Bennett B, Churg J, Spitzer A, Greifer I (1975) Recurrent hemolytic uremic syndrome: a case report. Clin Nephrol 4: 68–72

    PubMed  CAS  Google Scholar 

  • Dubilier LD, Chadwick JA, Leddy JP (1968) Thymic alymphoplasia with hemolytic uremic syndrome. J Pediatr 73: 714–726

    PubMed  CAS  Google Scholar 

  • Dyck RF, Kappell JE, Sheridan D, Card RD (1986) Reversible cyclosporine-associated hemolytic uremic syndrome in a renal transplant recipient: a role for a platelet aggregating factor? Transplant Proc 18: 228–229

    Google Scholar 

  • Eckel RH, Crowell EB, Waterhouse BE, Bosdech MJ (1977) Platelet-inhibiting drugs in thrombotic thrombocytopenic purpura. Arch Intern Med 137: 735–737

    PubMed  CAS  Google Scholar 

  • Edelsten AD, Tuck S (1978) Familial haemolytic uraemic syndrome. Arch Dis Child 53: 255–256

    PubMed  CAS  Google Scholar 

  • Ekberg M, Nilsson JM, Denneberg T (1974) Coagulation studies in hemolytic uremic syndrome and thrombotic thrombocytopenic purpura. Acta Med Scand 196: 373–382

    PubMed  CAS  Google Scholar 

  • Faguet GB, King MB (1974) Thrombotic thrombocytopenic purpura. Treatment with antiplatelet agents. Am J Med Scì 268: 113–116

    PubMed  CAS  Google Scholar 

  • Farr MJ, Roberts S, Morley AR, Dewar PJ, Roberts DF, Uldall PR (1975) The haemolytic-uraemic syndrome: a family study. Q J Med 44: 161–188

    PubMed  CAS  Google Scholar 

  • Feldman JD, Mardiney MR, Unanue ER, Cutting H (1966) The vascular pathology of thrombotic thrombocytopenic purpura: an immunohistochemical and ultrastructural study. Lab Invest 15: 927–946

    PubMed  CAS  Google Scholar 

  • Ferriero DM, Wolfsdorf JP (1981) Hemolytic uremic syndrome associated with Kawasaki disease. Pediatrics 68: 405–406

    PubMed  CAS  Google Scholar 

  • Fischer K, Poschmann A, Oster H (1971) Hämolyse bei schwerer Pneumonie infolge Neuraminidasewirkung. Monatsschr Kinderheilkd 119: 2–8

    PubMed  CAS  Google Scholar 

  • Fitzgerald PJ, Auerbach O, Frame E (1947) Thrombotic acro-angiothrombosis (platelet thrombosis of the capillaries, arterioles and venules. Blood 2: 519–541

    PubMed  CAS  Google Scholar 

  • Folman R, Arbus GS, Churchill B, Gaum L, Huber J (1978) Recurrence of the hemolytic uremic syndrome in a 3 year old child, 4 months after second renal transplantation. Clin Nephrol 10: 121–127

    PubMed  CAS  Google Scholar 

  • Fong JSC, Kaplan BS (1982) Impairment of platelet aggregation in hemolytic-uremic syndrome. Evidence for platelet “exhaustion”. Blood 60: 564–570

    PubMed  CAS  Google Scholar 

  • Fong JS, de Chadarevian JI, Kaplan BS (1982) Hemolytic uremic-syndrome. Current concepts and management. Pediatr Clin North Am 29: 835–865

    PubMed  Google Scholar 

  • Gasser C, Gautier E, Steck A, Siebenmann R, Oechslin R (1955) Hämolytisch-urämische Syndrome: bilaterale Nierenrindennekrosen bei akuten erworbenen hämolytischen Anämien. Schweiz Med Wochenschr 85: 905–909

    PubMed  CAS  Google Scholar 

  • Gianantonio C, Vitacco M, Mendilaharzu F, Rutt A (1964) Hemolytic uremic syndrome. J Pediatr 64: 478–491

    PubMed  CAS  Google Scholar 

  • Gianantonio C, Vitacco M, Mendilaharzu F, Gallo G, Sojo E (1973) The hemolytic uremic syndrome. Nephron 14: 174–192

    Google Scholar 

  • Gillor A, Bulla M, Roth B, Kussmann K, Schrör K, Tekook A, Gladtke E (1983) Plasmapheresis as a therapeutic measure in hemolytic uremic syndrome in children. Klin Wochenschr 61: 363–367

    PubMed  CAS  Google Scholar 

  • Goldstein MH, Gribetz D, Churg J (1979) Le syndrome hémolytique et urdmique et le purpura thrombotique thrombocytopdnique. In: Hamburger J, Crosnier J, Grünfeld JB (eds) Néphrologie. Flammarion, Paris, pp 896–925

    Google Scholar 

  • Gonzalo A, Mampaso F, Gallego N, Bellas C, Segui J, Ortuno J (1981) Hemolytic uremic syndrome with hypocomplementemia and deposits of IgM and C3 in the involved renal tissue. Clin Nephrol 16: 193–199

    PubMed  CAS  Google Scholar 

  • Gore I (1950) Disseminated arteriolar and capillary platelet thrombosis: a morphologic study of its histogenesis. Am J Pathol 26: 155–175

    PubMed  CAS  Google Scholar 

  • Habib R, Mathieu H, Royer P (1958) Maladie thrombotique artdrio-capillaire du rein chez l’enfant. Rev Fr Etud Clin Biol 3: 891–894

    PubMed  CAS  Google Scholar 

  • Habib R, Mathieu H, Royer P (1967) Le syndrome hémolytique et urdmique de l’enfant. Aspects cliniques et anatomiques de 27 observations. Nephron 4: 139–172

    PubMed  CAS  Google Scholar 

  • Habib R, Levy M, Gagnadoux MF, Broyer M (1982) Prognosis of the hemolytic uremic syndrome in children. In: Hamburger J, Crosnier J, Grünfeld JB, Maxwell M (eds) Advances in nephrology. Year Book. Medical Publishers, Chicago, pp 99–128

    Google Scholar 

  • Hagge WW, Holley KE, Burke EC, Stickler GB (1967) Hemolytic-uremic syndrome in two siblings. N Engl J Med 277: 138–139

    PubMed  CAS  Google Scholar 

  • Hauglustaine D, Van Damme B, Vanrenterghem Y, Michielsen P (1981) Recurrent hemolytic uremic syndrome during oral contraception. Clin Nephrol 15: 148–153

    PubMed  CAS  Google Scholar 

  • Hautekete M, Nagler J, Cuykens J, Parizel G, Laekeman G, Herman A (1986) 6 keto PGFIa levels and prostacyclin therapy in 2 adult patients with hemolytic uremic syndrome. Clin Nephrol 26: 157–159

    Google Scholar 

  • Hebert D, Sibley RK, Mauer SM (1986) Recurrence of hemolytic uremic syndrome in renal transplant recipients. Kidn Int 30: 51–58

    Google Scholar 

  • Hellman RM, Jackson DV, Buss DH (1980) Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome in HLA-identical siblings. Ann Intern Med 93: 283–284

    PubMed  CAS  Google Scholar 

  • Hensby CN, Lewis PJ, Hilgard P, Mufti GJ, House J, Webster J (1979) Prostacyclin deficiency in thrombotic thrombocytopenic purpura. Lancet 11: 748

    Google Scholar 

  • Javett SN, Senior B (1962) Syndrome of hemolysis, thrombopenia and nephropathy in infancy. Pediatrics 29: 209–223

    PubMed  CAS  Google Scholar 

  • John HD, Thoenes W (1982) The glomerular lesions in endotheliotropic hemolytic nephroangiopathy (hemolytic uremic syndrome, malignant nephrosclerosis, postpartal renal insufficiency). Pathol Res Pract 173: 236–259

    PubMed  CAS  Google Scholar 

  • Jones RW, Morris MC, Maisey MN, Saxton HM, Chantier C (1981) Endarterial urokinase in childhood hemolytic uremic syndrome. Kidney Int 20: 723–727

    PubMed  CAS  Google Scholar 

  • Jorgensen KA, Pedersen RS (1981) Familial deficiency of prostacyclin production stimulating factor in the hemolytic uremic syndrome of children. Thromb Res 21: 311–315

    PubMed  CAS  Google Scholar 

  • Kaplan BS (1977) Hemolytic uremic syndrome with recurrent episodes: an important subset. Clin Nephrol 8: 495–498

    PubMed  CAS  Google Scholar 

  • Kaplan BS, Drummond KN (1978) The hemolytic uremic syndrome is a syndrome. N Engl J Med 298: 964–966

    PubMed  CAS  Google Scholar 

  • Kaplan BS, Chesney RW, Drummond KN (1975) Hemolytic uremic syndrome in families. N Engl J Med 292: 1090–1093

    PubMed  CAS  Google Scholar 

  • Kaplan BS, Thomson PD, de Chadarevian JP (1977) The hemolytic uremic syndrome. Pediatr Clin North Am 23: 761–777

    Google Scholar 

  • Kapur S, Chandra R, Antonovych T (1977) Acute radiation nephritis. Light and electron microscopic observations. Arch Pathol Lab Med 101: 469–473

    PubMed  CAS  Google Scholar 

  • Karmali MA, Steele BT, Petric M, Lim C (1983) Sporadic cases of haemolytic uraemic syndrome associated with faecal cytotoxin and cytotoxin-producing Escherichia coli in stools. Lancet 1: 619–620

    PubMed  CAS  Google Scholar 

  • Khahn BT, Bathena D, Vaquez M, Luke RG (1976) Role of heparin in the outcome of adult hemolytic uremic syndrome. Nephron 16: 292–301

    Google Scholar 

  • Kibel MA, Barnard PJ (1968) The haemolytic-uraemic syndrome: a survey in Southern Africa. South Afr Med J 42: 692–698

    CAS  Google Scholar 

  • Kirchner KA, Smith RM, Gockerman JP, Luke RC (1982) Hereditary thrombotic thrombocytopenic purpura: microangiopathic hemolytic anemia, thrombocytopenia and renal insufficiency occurring in consecutive generations. Nephron 30: 28–30

    PubMed  CAS  Google Scholar 

  • Koster F, Levin J, Walker L, Tung KSK, Gilman RH, Rahaman MM, Majid MA, Islam S, Williams RC (1978) Hemolytic uremic syndrome after shigellosis. N Engl J Med 298: 927–933

    PubMed  CAS  Google Scholar 

  • Kwaan HC (1979) The pathogenesis of thrombotic thrombocytopenic purpura. Semin Thromb Hemost 5: 184–198

    PubMed  CAS  Google Scholar 

  • Lamvik JD (1962) Acute glomerulonephritis with hemolytic anemia in infants. Pediatrics 29: 224–236

    PubMed  CAS  Google Scholar 

  • Larbre P, Dechelette E, Sellem C, Parchoux B, Marchai A (1979) Le syndrome hémolytique et urémique récidivant. Pediatrie 34: 433–441

    PubMed  CAS  Google Scholar 

  • Leavitt TJ, Merigan TC, Freeman J (1971) Hemolytic-uremic-like syndrome following polycarboxylate interferon induction. Am J Dis Child 121: 43–47

    PubMed  CAS  Google Scholar 

  • Lehnert U, Maak B, Zinth F (1973) Beitrag zum Krankheitsbild des hämolytisch-urämischen Syndroms. Folia Haematol (Leipz) 1: 39–48

    Google Scholar 

  • Leithner C, Sinzinger H, Pohanka E, Schwartz M, Kretchmer G, Syre G (1982) Recurrence of haemolytic uraemic syndrome triggered by cyclosporin after renal transplantation. Lancet 1: 1470

    PubMed  CAS  Google Scholar 

  • Levin M, Walters MDS,Waterfield MD, Stroobant P, Cheng DJ, Barratt TM (1986) Platelet-derived growth factors as possible mediators of vascular proliferation in the sporadic haemolyticuraemic syndrome. Lancet 11: 830–833

    Google Scholar 

  • Levine S, Shearn MA (1964) Thrombotic thrombocytopenic purpura and systemic lupus erythemathosus. Arch Intern Med 113: 826–836

    PubMed  CAS  Google Scholar 

  • Levy M, Gagnadoux MF, Habib R (1980) Pathology of the hemolytic uremic syndrome in children. In: Remuzzi G, Mecca G, de Gaetano G (eds) Hemostasis, prostaglandins and renal disease. Raven, New York, pp 383–397

    Google Scholar 

  • Lian ECY, Harkness DR, Byrnes JJ, Wallach H, Nunez R (1979) Presence of a platelet aggregating factor in the plasma of patients with thrombotic thrombocytopenic purpura. Blood 53: 333–338

    PubMed  CAS  Google Scholar 

  • Lohrmann HP, Adam W, Heymer B, Kubanek B (1973) Microangiopathic hemolytic anemia in metastatic carcinoma. Ann Intern Med 79: 368–375

    PubMed  CAS  Google Scholar 

  • Loirat C, Beaufils F, Sonsino E, Habib R, Andre JL, Broyer M, Costil J, Gagnadoux MF, Guyot C, Mathieu H (1982) Urokinase treatment for hemolytic uremic syndrome in childhood (abstract). Int J Pediatr Nephrol 3: 46

    Google Scholar 

  • Loirat C, Sonsino E, Varga Moreno A, Pillion G, Mercier JC, Beaufils F, Mathieu H (1984) Hemolytic-uremic syndrome: an analysis of the natural history and prognostic features. Acta Paediatr Scand 73: 505–514

    PubMed  CAS  Google Scholar 

  • Lyman NW, Michaelson R, Viscuno RL, Winn R, Mulgoankar S, Jacobs MG (1983) Mitomycininduced hemolytic-uremic syndrome. Successful treatment with corticosteroids and intensive plasma exchange. Arch Intern Med 143: 1617–1618

    PubMed  CAS  Google Scholar 

  • MacWhinney JB, Packer JT, Miller G, Greendyke RM (1962) Thrombotic thrombocytopenic purpura in childhood. Blood 19: 181–199

    Google Scholar 

  • Masotti G, Poggesi L, Galanti G, Neri-Serneri GG (1979) Stimulation of prostacyclin by dipyridamole. Lancet 1: 1412

    PubMed  CAS  Google Scholar 

  • Matsui A, Nagasawa M, Suetake N (1980) Hemolytic-uremic syndrome: a report of an outbreak (abstract). Pediatr Res 14: 997

    Google Scholar 

  • McLean MM, Jones HC, Sutherland DA (1966) Haemolytic uraemic syndrome: a report of an outbreak. Arch Dis Child 41: 76–81

    PubMed  CAS  Google Scholar 

  • Mehta K, Jani P, Gokarn S, Ali U (1980) Hemolytic-uremic syndrome. A tropical look. Int J Pediatr Nephrol 1: 98–103

    Google Scholar 

  • Mettler HE (1969) Isolation of a microtatobiote from patients with hemolytic-uremic syndrome and thrombotic thrombocytopenic purpura and from mites in the United States. N Engl J Med 281: 1023–1027

    PubMed  CAS  Google Scholar 

  • Missiani R, Appiani AC, Edefonti A, Gotti E, Bettinelli A, Giani M, Rossi E, Remuzzi G, Mecca G (1982) Haemolytic-uraemic syndrome: therapeutic effect of plasma infusion. Br Med J 285: 1304–1306

    Google Scholar 

  • Moake JL, Rudy CK, Troll JH, Weinstein MJ, Colannino NM, Azocar M, Seder RH, Hong SL, Deykin D (1982) Unusually large plasma factor VIII: von Willebrand factor multimers in chronic relapsing thrombotic thrombocytopenic purpura. N Engl J Med 307: 1432–1435

    PubMed  CAS  Google Scholar 

  • Moncada S, Korbut R (1978) Dipyridamole and the other phosphodiesterase inhibitors act as antithrombotic agents by potentiating endogenous prostacyclin. Lancet 1: 1286–1289

    PubMed  CAS  Google Scholar 

  • Monnens L, Van Collenburg J, De Jong M, Zoethout H, Van Wieringen P (1978) Treatment of the hemolytic uremic-syndrome. Comparison of the results of heparin treatment with the results of streptokinase treatment. HeIv Paediatr Acta 33: 321–328

    CAS  Google Scholar 

  • Monnens L, Molenaar J, Lambert PH, Proesmans W, Van Munster P (1980a) The complement system in hemolytic uremic syndrome in children. Clin Nephrol 13: 168–171

    PubMed  CAS  Google Scholar 

  • Monnens L, Sanwel-Mantingh M, Lestijo BJ, Van Munster P (1980b) Serum immunoglobulin levels in the hemolytic uremic syndrome in children. Acta Paediatr Belg 33: 157–161

    PubMed  CAS  Google Scholar 

  • Monnens L, Van Aken W, de Jong M (1982) Active intravascular coagulation in the epidemic form of hemolytic uremic syndrome. Clin Nephrol 17: 284–287

    PubMed  CAS  Google Scholar 

  • Monnens L, Van de Meer W, Langenhuysen C, Van Munster P, Van Oostrom C (1985) Platelet aggregating factor in the epidemic form of hemolytic-uremic syndrome in children. Clin Nephrol 24: 135–137

    PubMed  CAS  Google Scholar 

  • Moorthy B, Makker SP (1979) Hemolytic-uremic syndrome associated with pneumococcal sepsis. J Pediatr 95: 558–559

    PubMed  CAS  Google Scholar 

  • Morel-Maroger L (1980) Adult hemolytic uremic syndrome. Kidney Int 18: 125–134

    Google Scholar 

  • Morel-Maroger L, Kanfer A, Solez K, Sraer JD, Richet G (1979) Prognostic importance of vascular lesions in acute renal failure with microangiopathic hemolytic anemia (hemolytic uremic syndrome). Clinicopathologic study in 20 adults. Kidney Int 15: 548–558

    PubMed  CAS  Google Scholar 

  • Moschcowitz E (1925) An acute febrile pleiochromic anaemia with hyaline thrombosis of the terminal arterioles and capillaries. An undescribed disease. Arch Intern Med 36: 89–93

    Google Scholar 

  • Mota-Hernandez F, Gordillo-Paniagua G (1964) Microangiopathia thrombotica renal. Bol Med Hosp Inf Mex 21: 691–696

    CAS  Google Scholar 

  • Mujibur-Rahaman M, Jamiul Alam AKM, Islam MR, Greenough WB, Lindenbaum J (1975) Shigella baccillus dysentery associated with marked leukocytosis and erythrocyte fragmentation. John Hopkins Med J 136: 65–69

    Google Scholar 

  • Nissenson AR, Krumlovsky FA, Del Greco F (1979) Post partum hemolytic-uremic syndrome. Late recovery after prolonged maintenance dialysis. DAMA 242: 173–175

    CAS  Google Scholar 

  • Norkin SA, Freedman HH, Evans GW (1967) Thrombotic thrombocytopenic purpura in siblings. Am J Med 43: 294–303

    PubMed  CAS  Google Scholar 

  • O’Regan S, Chesney RW, Kaplan BS, Drummond KN (1980a) Red cell membrane phospholipid abnormalities in the hemolytic uremic syndrome. Clin Nephrol 15: 14–17

    Google Scholar 

  • O’Regan S, Chesney RW, Mongeau JG, Robitaille P (1980b) Aspirin and dipyridamole therapy in the hemolytic uremic syndrome. J Pediatr 97: 473–476

    PubMed  Google Scholar 

  • O’Regan S, Robitaille P, Mongeau JC, McLonghlin B (1980c) The hemolytic uremic syndrome associated with ECHO 22 infection. Clin Pediatr 19: 125–127

    Google Scholar 

  • Perret B, Gaze H, Zimmermann A, Oetliker O (1979) Syndrome hémolytique urémique familial non endémique: néphrectomie et transplantation. Heiv Paediatr Acta 34: 167–176

    CAS  Google Scholar 

  • Ponticelli C, Maestri O, Imbasciati E, Brancaccio D, Rossi E (1977) Late recovery of renal function in a woman with the hemolytic uremic syndrome. Clin Nephrol 8: 367–370

    PubMed  CAS  Google Scholar 

  • Ponticelli C, Rivolta E, Imbasciati E, Rossi E, Mannucci PM (1980a) Hemolytic uremic syndrome in adults. Arch Intern Med 140: 353–357

    PubMed  CAS  Google Scholar 

  • Ponticelli C, Imbasciati E, Rivolta F, Rossi E, Manucci PM (1980b) Long term follow-up of postpartum hemolytic-uremic syndrome treated with heparin and antiplatelet agents. In: Remuzzi G, Mecca G, de Gaetano G (eds) Hemostasis, prostaglandins and renal disease. Raven, New York, pp 433–441

    Google Scholar 

  • Poschmann A, Fischer K (1974) Hämolytisch-urämisches Syndrom. Med Klin 69: 1821–1834

    PubMed  CAS  Google Scholar 

  • Powell HR, Ekert HS (1974) Streptokinase and antithrombotic therapy in the hemolytic uremic syndrome. J Pediatr 84: 345–349

    PubMed  CAS  Google Scholar 

  • Powell HR, Taylor CM, McCredie DA (1983) Vitamin E treatment of the haemolytic uraemic syndrome (abstract). Eur J Pediatr 140: 200

    Google Scholar 

  • Proesmans W, Eeckels R (1974) Has heparin changed the prognosis of the hemolytic-uremic syndrome? Clin Nephrol 2: 169–173

    PubMed  CAS  Google Scholar 

  • Proesmans W, Binda ki Muaka P, Van Damme B, Vermylen J, Vlietinck R, Eeckels R (1980) Anticoagulant versus no specific treatment in childhood hemolytic uremic syndrome. A randomized prospective study. In: Gruskin AB,Norman ME (eds) Developments in nephrology B. Pediatric nephrology. Proceedings of the fifth international pediatric nephrology symposium 1980, pp 171–174

    Google Scholar 

  • Raghupathy P, Date A, Shastry JCM, Sudarsanam AA, Jadhav M (1978) Haemolytic-uraemic syndrome complicating Shigella dysentery in South Indian children. Br Med J 1: 1518–1521

    PubMed  CAS  Google Scholar 

  • Ray CG, Portman JN, Stamm SJ, Hickman RD (1971) Hemolytic uremic syndrome and myocarditis: association with Coxsackie virus B infection. Am J Dis Child 122: 418–420

    PubMed  CAS  Google Scholar 

  • Remuzzi G, Misiani R, Marchesi D, Livio M, Mecca G, de Gaetano G, Donati MB (1978) Haemolytic uraemic syndrome: deficiency of a plasma factor regulating prostacyclin activity? Lancet 11: 871–872

    Google Scholar 

  • Remuzzi G, Misiani R, Marchesi D, Livio M, Mecca G, de Gaetano G, Donati MB (1979) Treatment of the hemolytic-uremic syndrome with plasma. Clin Nephrol 12: 279–284

    PubMed  CAS  Google Scholar 

  • Rizzoni G, Zachello G, Menegazzo A, Paranello L, Andreetta B, Bucolo C (1982) La syndrome uremico emolitica oggi: una entita da reconsiderare. Riv Ital Pediatr 8: 69–76

    Google Scholar 

  • Rossi EC, Redondo D, Borges WH (1974) Thrombotic thrombocytopenic purpura. Survival following treatment with aspirin, dipyridamole and prednisone. JAMA 228: 1141–1145

    PubMed  CAS  Google Scholar 

  • Rubinstein MA, Kagan BM, MacGillviray, Merliss R, Sacks H (1959) Unusual remission in a case of thrombotic thrombocytopenic purpura syndrome following fresh blood exchange transfusion. Ann Intern Med 51: 1409–1419

    PubMed  CAS  Google Scholar 

  • Seger R, Joller P, Baerlocher K, Kenny A, Dulake C, Leumann E, Spierig M, Hitzig WH (1980) Hemolytic uremic syndrome associated with neuraminidase producing microorganisms: treatment with exchange transfusion. Helv Paediatr Acta 35: 359–367

    PubMed  CAS  Google Scholar 

  • Segonds A, Lauradour N, Suc J, Orfila C (1979) Postpartum hemolytic uremic syndrome: a study of three cases with a review of the literature. Clin Nephrol 12: 229–242

    PubMed  CAS  Google Scholar 

  • Sharman VL, Goodwin FJ (1980) Hemolytic uremic syndrome following chicken pox. Clin Nephrol 14: 49–51

    PubMed  CAS  Google Scholar 

  • Shashaty GG, Atamer MA (1974) Hemolytic uremic syndrome associated with infectious mononucleosis. Am J Dis Child 127: 720–722

    PubMed  CAS  Google Scholar 

  • Shigematsu H, Dikman SH, Churg J, Grishman E, Duffy JL (1976) Mesangial involvement in hemolytic uremic syndrome. A light and electron microscopic study. Am J Pathol 85: 349–362

    PubMed  CAS  Google Scholar 

  • Shinton NK, Galpine JF, Kendall AC, Williams AP (1964) Hemolytic anemia with acute renal disease. Arch Dis Child 39: 455–464

    PubMed  CAS  Google Scholar 

  • Shumway CN, Miller C (1957) An unusual syndrome of hemolytic anemia, thrombocytopenic purpura and renal disease. Blood 12: 1045–1060

    PubMed  Google Scholar 

  • Siegel BM, Friedman IA, Kessler S, Schwarts SO (1957) Thrombohemolytic thrombocytopenic purpura and lupus erythematosus. Ann Intern Med 47: 1022–1029

    PubMed  CAS  Google Scholar 

  • Siegler RL, Bond RE (1980) Simultaneous microangiopathic hemolytic anemia, thrombocytopenia and acute nephropathy in a mother and a child. Am J Dis Child 134: 991–992

    PubMed  CAS  Google Scholar 

  • Singer K (1954) Thrombotic thrombocytopenic purpura. Adv Intern Med 6: 195–234

    PubMed  CAS  Google Scholar 

  • Singer K, Bornstein FP, Wile SA (1947) Thrombotic thrombocytopenic purpura. Blood 2: 542–554

    PubMed  CAS  Google Scholar 

  • Sorrenti LY, Lewy PR (1978) The hemolytic uremic syndrome: experience at a center in the Midwest. Am J Dis Child 132: 59–62

    PubMed  CAS  Google Scholar 

  • Spirer Z, Knobel B, Earon J, Heyman I, Bogair N (1977) Recurrent hemolytic uremic syndrome. Helv Paediatr Acta 32: 165–172

    PubMed  CAS  Google Scholar 

  • Steele BT, Lirenman DS (1978) Acute radiation nephritis and the hemolytic uremic syndrome. Clin Nephrol 11: 272–274

    Google Scholar 

  • Steele BT, Murphy N, Rance CP (1982) An outbreak of hemolytic uremic syndrome associated with ingestion of fresh apple juice. J Pediatr 101: 963–965

    PubMed  CAS  Google Scholar 

  • Stuart J, Winterborn MH, White RHR, Flinn RM (1974) Thrombotic therapy in haemolytic uraemic syndrome. Br Med J 3: 217–221

    PubMed  CAS  Google Scholar 

  • Symmers WSC (1952) Thrombotic microangiopathic haemolytic anaemia. Br Med J 2: 897–903

    PubMed  CAS  Google Scholar 

  • Thoenes W, John HD (1980) Endotheliotropic nephroangiopathy and its various forms: thrombotic microangiopathy, primary malignant nephrosclerosis, hemolytic uremic syndrome. Klin Wochenschr 58: 173–184

    PubMed  CAS  Google Scholar 

  • Thysell H, Oxelius V, Norlin M (1982) Successful treatment of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura with fresh frozen plasma and plasma exchange. Acta Med Scand 212: 285–288

    PubMed  CAS  Google Scholar 

  • Trompeter RS, Schwartz R, Chantler C, Dillon MJ, Haycock GB (1983) Haemolytic uraemic syndrome: an analysis of prognostic features. Arch Dis Child 58: 101–105

    PubMed  CAS  Google Scholar 

  • Tune BM, Groshong T, Plumer LB, Mendoza SA (1974) The hemolytic uremic syndrome in siblings: a prospective study. J Pediatr 85: 682–683

    PubMed  CAS  Google Scholar 

  • Tune BM, Leavitt T.1, Gribbe Ti (1979) The hemolytic uremic syndrome in California: a review of 28 non-heparinized cases with long-term follow-up. J Pediatr 84: 304–310

    Google Scholar 

  • Turi S, Beattie TJ, Belch II, Murphy AV (1986) Disturbances of prostacyclin metabolism in children with hemolytic-uremic syndrome and in first degree relatives. Clin Nephrol 25: 193–198

    PubMed  CAS  Google Scholar 

  • Ullis KC, Rosenblatt RM (1973) Shiga bacillus dysentery complicated by bacteremia and disseminated microvascular coagulation. J Pediatr 83: 90–93

    PubMed  CAS  Google Scholar 

  • Umlass J, Kaiser J (1970) Thrombo-hemolytic thrombocytopenic purpura (TTP): a disease or a syndrome? Am J Med 49: 723–728

    Google Scholar 

  • Upadyaya K, Barwick K, Fishaut M, Kashgarian M, Siegel NJ (1980) The importance of non-renal involvement in hemolytic uremic syndrome. Pediatrics 65: 115–120

    Google Scholar 

  • Upshaw JD (1978) Congenital deficiency of a factor in normal plasma that reverses microangiopatic hemolysis and thrombocytopenia. N Engl J Med 298: 1350–1352

    PubMed  Google Scholar 

  • Uttley WS (1970) Serum levels of fibrin/fibrinogen degradation products in the haemolytic uraemic syndrome. Arch Dis Child 45: 585–589

    Google Scholar 

  • Van Buren D, Van Buren CT, Flechner SM, Maddox AM, Verani R, Kahan BD (1985) De novo hemolytic uremic syndrome in renal transplant recipients immunosuppressed with cyclosporine. Surgery 98: 54–62

    PubMed  Google Scholar 

  • Van Rhijn A, Donckerwolcke RA, Kuyten RH, Van der Heiden C (1977) Liver damage in the hemolytic uremic syndrome. Helv Paediatr Acta 32: 77–81

    PubMed  Google Scholar 

  • Van Stiegmann G, Lilly JR (1979) Surgical lesions of the colon in the hemolytic uremic syndrome. Surgery 85: 357–359

    PubMed  Google Scholar 

  • Vitacco M, Sanchez-Avalos J, Gianantonio C (1973) Heparin therapy in the hemolytic uremic syndrome. J Pediatr 83: 271–275

    PubMed  CAS  Google Scholar 

  • Waddle AJH, Matz LR (1966) Haemolytic uraemic syndrome: a report of two cases in adults. Med J Aust 2: 893–897

    Google Scholar 

  • Wallace DC, Lovric A, Clubb JS, Carseldine DB (1975) Thrombotic thrombocytopenic purpura in four siblings. Am J Med 58: 724–734

    PubMed  CAS  Google Scholar 

  • Webster J, Rees AJ, Lewis PJ, Hensby CN (1980) Prostacyclin deficiency in haemolytic uraemic syndrome. Br Med J 2: 271–272

    Google Scholar 

  • Whitington PF, Friedman AL, Chesney RW (1979) Gastrointestinal disease in the hemolytic uremic syndrome. Gastroenterology 76: 728–733

    PubMed  CAS  Google Scholar 

  • Zuelzer WW, Palmers HD, Newton WA (1950) Unusual glomerulonephritis in younger children. Am J Pathol 26: 1019–1039

    PubMed  CAS  Google Scholar 

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  1. Kindergeneeskunde — Kindernefrologie, Universitaire Ziekenhuizen Leuven, U.Z. Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium

    R. Eeckels

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  1. W. Proesmans
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M. Brandis P. Frick K. Kochsiek G. A. Martini A. Prader

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Proesmans, W., Eeckels, R. (1989). The Hemolytic Uremic Syndromes. In: Brandis, M., Frick, P., Kochsiek, K., Martini, G.A., Prader, A. (eds) Ergebnisse der Inneren Medizin und Kinderheilkunde / Advances in Internal Medicine and Pediatrics. Ergebnisse der Inneren Medizin und Kinderheilkunde / Advances in Internal Medicine and Pediatrics, vol 58. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74042-8_3

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