Skip to main content
SpringerLink
Log in

The Significance of Food Allergy in Atopic Dermatitis

  • Conference paper
Food Allergy in Infancy and Childhood

  • 111 Accesses

Abstract

Atopic dermatitis is an inflammatory skin disorder which frequently begins in early infancy. It is characterized by extreme pruritus, chronically relapsing course, and specific distribution. The rash is generally an erythematous, papulovesicular eruption, frequently with serous discharge and crusting, and progresses to a scaly, lichenified rash over time [1]. The distribution of the rash typically varies with age [2], involving the cheeks and extensor surfaces of the arms and legs in infancy, the flexor surfaces in the young child, and flexor surfaces, hands and feet in the teenage patient and young adult. Unlike most dermatoses, atopic dermatitis has no primary skin lesion but is identified by a constellation of symptoms. The classification system recently proposed by Hanifin and Rajka [3] has been generally accepted and provides suitable diagnostic criteria for the disorder.

Supported by grants AI24439 and AI00830 from the National Institute of Allergy and Infectious Diseases and by grants RR-30 and RR-00052 from the General Clinical Research Centers Program of the Division of Research Resources, National Institutes of Health. Data was managed and analyzed with CLINFO. The author is a recipient of the Allergic Diseases Academic Award, NIH.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Blaylock WK (1976) Atopic dermatitis: diagnosis and pathobiology. J Allergy Clin Immunol 57:62–79

    Article  PubMed  CAS  Google Scholar 

  2. Hill LW, Sulzberger MG (1935) Evaluation of atopic dermatitis. Arch Belg Dermatol Syphiligr 32:451–463

    Google Scholar 

  3. Hanifin JM, Rajka G (1980) Diagnostic features of atopic dermatitis. Acta Derm Venerol 92 (Suppl): 44–47

    Google Scholar 

  4. Hanifin JM (1981) Atopic dermatitis. In: Safari B, Good RA (eds) Comprehensive immunology. Plenum, New York, p 301

    Google Scholar 

  5. Wise F, Sulzberger MB (1983) Yearbook of dermatology and syphilology. Yearbook Medical, Chicago, p 59

    Google Scholar 

  6. Johnson ML (1977) Prevalence of dermatologic disease among persons 1–74 years of age: United States. Advance data from vital and health statistics of the National Center for Health Statistics, no 4

    Google Scholar 

  7. Kjellman N-IM (1977) Atopic disease in seven year old children. Acta Paediatr Scand 66:465–471

    Article  PubMed  CAS  Google Scholar 

  8. Hanifin JM (1986) Pharmacophysiology of atopic dermatitis. Clin Rev Allergy 4:43–65

    PubMed  CAS  Google Scholar 

  9. Leung DYM, Geha RS (1986) Immunoregulatory abnormalities in atopic dermatitis. Clin Rev Allergy 4:67–86

    PubMed  CAS  Google Scholar 

  10. NIAID Task Force Report (1979) Dermatologic allergy. Asthma and the other allergic diseases. NIH Publication no 79-387, (1974) p 375

    Google Scholar 

  11. Johnson E, Irons J, Patterson R, Roberts M (1974) Serum IgE concentration in atopic dermatitis. J Allergy Clin Immunol 54:94–99

    Article  PubMed  CAS  Google Scholar 

  12. Rajka G (1975) The Aetiology of atopic dermatitis. In: Rook A (ed) Major problems in dermatology. Atopic dermatitis, vol 3. Saunders, London, pp 52–54

    Google Scholar 

  13. Hofman DR, Yamamoto FY, Sellar B, Haddad Z (1975) Diagnosis of IgE-me-diated reactions to food antigens by radioimmunoassay. Clin Immunol 55:256–267

    Google Scholar 

  14. Pasternack B (1965) The prediction of asthma in infantile eczema. J Pediatr 66:164–165

    Article  PubMed  Google Scholar 

  15. Stifler WC (1965) A twenty-one year follow-up of infantile eczema. J Pediatr 66:166–167

    Article  PubMed  Google Scholar 

  16. Mihm MC, Soter NA, Dvorak HF, Austen KF (1976) The structure of normal skin and the morphology of atopic eczema. J Invest Dermatol 67:305–312

    Article  PubMed  Google Scholar 

  17. Sampson HA (1985) Role of immediate food hypersensitivity in the pathogenesis of atopic dermatitis. J Allergy Clin Immunol 71:473–478

    Article  Google Scholar 

  18. Sampson HA, Jolie PA (1984) Increased plasma histamine concentrations after food challenges in children with atopic dermatitis. N Engl J Med 311:372–376

    Article  PubMed  CAS  Google Scholar 

  19. Sampson HA, Broadbent K (1987) “Spontaneous” basophil histamine release and histamine releasing factor in patients with atopic dermatitis and food hypersensitivity. J Allergy Clin Immunol 79:241

    Google Scholar 

  20. Paganelli R, Levinsky RJ, Brostoff J, Wraith DG (1979) Immune complexes containing food proteins in normal and atopic subjects after oral challenge and effect of sodium cromoglycate on antigen absorption. Lancet 1:1270

    Article  PubMed  CAS  Google Scholar 

  21. Brostoff J, Carini C, Wraith DG, Johns P (1979) Production of IgE complexes by allergen challenge in atopic patients and the effect of sodium cromoglycate. Lancet 1:1268

    Article  PubMed  CAS  Google Scholar 

  22. Paganelli R, Atherton DJ, Levinsky R (1983) Differences between normal and milk allergic subjects in their immune responses after milk ingestion. Arch Dis Child 58:201

    Article  PubMed  CAS  Google Scholar 

  23. Chenowith DE, Hugli TE (1980) Biologically active peptides of complement: techniques and significance of C3a and C5a measurement. In: Nakamura RM, Tucker ES (eds) Immunoassays: clinical laboratory techniques for the 1980’s. Liss, New York, pp 443–461

    Google Scholar 

  24. Sampson HA, McCaskill CM (1985) Food hypersensitivity in atopic dermatitis: evaluation of 113 patients. J Pediatr 107:669

    Article  PubMed  CAS  Google Scholar 

  25. Dolovich J, Hargreave FE, Chalmers R, Shier KJ, Gauldre J, Bienenstock J (1973) Late cutaneous allergic responses in isolated IgE-dependent reactions. J Allergy Clin Immunol 52:38

    Article  PubMed  CAS  Google Scholar 

  26. Solley GO, Gleich GJ, Jordan RE, Schroeter AL (1976) The late phase of the immediate wheal and flare skin reaction: its dependence upon IgE antibodies. J Clin Invest 58:408

    Article  PubMed  CAS  Google Scholar 

  27. Brunner M, Walzer M (1928) Absorption of undigested proteins in human beings: the absorption of unaltered fish protein in adults. Arch Intern Med 42:173

    Google Scholar 

  28. Wilson SJ, Walzer M (1935) Absorption of undigested proteins in human beings. IV. Absorption of unaltered egg protein in infants. Am J Dis Child 50:49

    CAS  Google Scholar 

  29. Gleich GJ, Leiferman KM (1986) Eosinophils and hypersensitivity disease. In: Reed CE (ed) Proceedings of the XII International Congress of Allergology and Clinical Immunology. Mosby, St. Louis, pp 124–130

    Google Scholar 

  30. Leiferman KM, Peters MS, Gleich GJ (1986) The eosinophil and cutaneous edema. J Am Acad Dermatol 15:513

    Article  PubMed  CAS  Google Scholar 

  31. Leiferman KM, Ackerman SJ, Sampson HA, Haugen HS, Venenice PY, Gleich GJ (1985) Dermal deposition of eosinophil granule major basic protein in atopic dermatitis: comparison with onchocerciasis. N Engl Med 313:282–285

    Article  CAS  Google Scholar 

  32. Gleich GJ, Frigas E, Loegering DA, Wassom DL, Steinmuller D (1979) Cytotoxic properties of eosinophil major basic protein. J Immunol 123:2925–2927

    PubMed  CAS  Google Scholar 

  33. O’Donnel MC, Ackerman SJ, Gleich GJ, Thomas LL (1983) Activation of basophil and mast cell histamine release by eosinophil granule major basic protein. J Exp Med 157:1981–1991

    Article  Google Scholar 

  34. Thueson DO, Speck LS, Lett-Brown MA, Grant JA (1979) Histamine-releasing activity. I. Production by mitogen-or antigen-stimulated human mononuclear cells. J Immunol 123:626

    PubMed  CAS  Google Scholar 

  35. Thueson DO, Speck LS, Lett-Brown MA, Grant JA (1979) Histamine-releasing activity. II. Interaction with basopohils and physicochemical characterization. J Immunol 123:633

    CAS  Google Scholar 

  36. Sedgwick JD, Holt PG, Turner KJ (1981) Production of a histamine-releasing lymphokine by antigen-or mitogen-stimulated human peripheral T cells. Clin Exp Immunol 45:409

    PubMed  CAS  Google Scholar 

  37. Kaplan AP, Haak-Frendscho M, Fauci A, Dinarello L, Haibert E (1985) A histamine-releasing factor from activated human mononuclear cells. J Immunol 135:2027

    PubMed  CAS  Google Scholar 

  38. Schulman ES, Proud D, Liu MC, MacGlashan DW, Lichtenstein LM, Plaut M (1985) Human lung macrophages induce histamine release from basophils and mast cells. Am Rev Respir Dis 131:230

    PubMed  CAS  Google Scholar 

  39. Orchard MA, Kagey-Sobotka A, Proud D, Lichtenstein LM (1986) Basophil histamine release induced by a substance from stimulated human platelets. J Immunol 136:2240

    PubMed  CAS  Google Scholar 

  40. McDonald SM, Lichtenstein LM, Proud D, Plaut M, Naclerio RM, MacGlashan DW, Kagey-Sobotka A (1987) Studies of IgE-dependent histamine releasing factors: heterogeneity of IgE. J Immunol 139:506

    Google Scholar 

  41. Marone G, Giugliano R, Lembo G, Ayala F (1986) Human basophil releasability. II. Changes in basopohil releasability in patients with atopic dermatitis. J Invest Dermatol 87:19

    Article  PubMed  CAS  Google Scholar 

  42. Yodoi J, Ishizaka K (1979) Lymphocytes bearing Fc-receptors for IgE. 1. Presence of human and rat lymphocytes with FcE-receptors. J Immunol 122:2577

    PubMed  CAS  Google Scholar 

  43. Spiegelberg HL (1984) Structure and function of Fc receptors for IgE on lymphocytes, monocytes and macrophages. Adv Immunol 35:61

    Article  PubMed  CAS  Google Scholar 

  44. Capron M, Spiegelberg HL, Prin L, Bennich H, Butterworth AE, Pierce RJ, Ouaissi M, Capron A (1984) Role of IgE receptors in effector function of human eosinophils. J Immunol 132:462

    PubMed  CAS  Google Scholar 

  45. Capron A, Ameisen JC, Joseph M, Auriault C, Tonnel AB, Caen J (1985) New functions for platelets and their pathological implications. Int Arch Allergy Appl Immunol 77:107

    Article  PubMed  CAS  Google Scholar 

  46. Cines DB, van der Keyl H, Levinson AI (1986) In vitro binding of an IgE protein to human platelets. J Immunol 136:3433

    PubMed  CAS  Google Scholar 

  47. Bruynzeel-Koomen C, van Wichen DF, Toonstra J, Berrens L, Bruynzeel PLB (1986) The presence of IgE molecules on epidermal Langerhans cells in patients with atopic dermatitis. Arch Dermatol Res 278:199

    Article  PubMed  CAS  Google Scholar 

  48. Sampson HA, Albergo R (1984) Comparison of results of skin tests, RAST, and double-blind placebo-controlled food challenges in children with atopic dermatitis. J Allergy Clin Immunol 74:26–33

    Article  PubMed  CAS  Google Scholar 

  49. Burks AW, Sampson HA (1988) A controlled trial of oral cromolyn in children with atopic dermatitis and documented food hypersensitivity. J Allergy Clin Immunol 81:417–423

    Article  PubMed  CAS  Google Scholar 

  50. Ohman S, Johansson SGO (1974) Immunoglobulins in atopic dermatitis. Acta Derm Venerol 54:193–202

    PubMed  CAS  Google Scholar 

  51. Stone SP, Gleich GJ, Muller SA (1976) Atopic dermatitis and IgE relationship between changes in IgE levels and severity of disease. Arch Dermatol 112:1254–1255

    Article  PubMed  CAS  Google Scholar 

  52. Kajosaari M, Saarinen UM (1983) Prophylaxis of atopic disease by six months total solid food elimination. Acta Paediatr Scand 72:411

    Article  PubMed  CAS  Google Scholar 

  53. Saarinen UM, Kajosaari M (1980) Does dietary elimination in infancy prevent or only postpone a food allergy? Lancet 1:166

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. H. A. Sampson
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Kinderklinik Dr. v. Haunersches Kinderspital, Universität München, Lindwurmstraße 4, 8000, München 2, Germany

    H. K. Harms

  2. Kinder- und Poliklinik, Universitätsklinikum Rudolf Virchow Standort, Charlottenburg Heubnerweg 6, 1000, Berlin 19, Germany

    U. Wahn

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Sampson, H.A. (1989). The Significance of Food Allergy in Atopic Dermatitis. In: Harms, H.K., Wahn, U. (eds) Food Allergy in Infancy and Childhood. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74357-3_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-74357-3_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-50636-2

  • Online ISBN: 978-3-642-74357-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation