Abstract
Selenium has been shown to act as an anticarcinogen in many experimental studies but it is also a potent toxin, and the question may be raised whether anticarcinogenic effects can be mediated by cytotoxicity. It is, for example, known that one of the toxic effects of selenium is DNA fragmentation (Shamberger 1985), and DNA fragmentation induced by other toxic substances can lead to an activation of the nuclear enzyme poly (ADP-ribose)polymerase (PARP) (Berger 1985). This enzyme utilizes NAD as a substrate, and it has been proposed that an extensive DNA fragmentation may lead to cell death via NAD depletion. It is thus possible that selenite can interact with other DNA-damaging compounds so that it selectively kills DNA-damaged cells.
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© 1989 Springer-Verlag Berlin Heidelberg
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Högberg, J., Garberg, P., Ståhl, A. (1989). Studies on Selenite-Induced DNA Fragmentation and the Role of Poly(ADP Ribose)Polymerase in Selenite Toxicity. In: Wendel, A. (eds) Selenium in Biology and Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74421-1_15
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DOI: https://doi.org/10.1007/978-3-642-74421-1_15
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