Abstract
The hepatitis B viruses, also called hepadnaviruses, are enveloped DNA viruses which primarily infect liver cells (reviewed by Ganem and Varmus 1987). The most important member of this virus family is the human hepatitis B virus (HBV; Dane et al. 1970), which is the causative agent of a severe form of hepatitis in humans. Since the virus is preferentially transmitted by contact with infected blood or blood products, this form of hepatitis was called serum hepatitis or hepatitis B in contrast to hepatitis A, which is caused by a Picornavirus typically transmitted by contaminated food.
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References
Acs G, Sells M, Purcell R, Price P, Engle R, Shapiro M, Popper H (1987) Hepatitis B virus produced by transfected Hep G2 cells causes hepatitis in chimpanzees. Proc Natl Acad Sci USA 84: 4641–4644
Babinet C, Farza H, Morello D, Hadchouel M, Pourcel C (1985) Specific expression of hepatitis B surface antigen (HBsAg) in transgenic mice. Science 230: 1160–1163
Bartenschlager R, Schaller H (1988) The amino terminal domain of the hepadnaviral P-gene encodes the terminal protein (genome linked protein) believed to prime reverse transcription The EMBO Journal 7: 4185–4192.
Chisari F, Pinkert C, Milich D, Filipi P, McLachlan A, Palmiter R, Brinster R (1985) A transgenic mouse model of the chronic hepatitis B surface antigen carrier state. Science 230: 1157–1160
Chang C, Jeng K, Hu C, Lo S, Su T, Ting L, Chou C, Han S, Pfaff E, Salfeld J, Schaller H (1987) Production of hepatitis B virus in vitro by transient expression of cloned HBV DNA in a hepatoma cell line. EMBO J. 6: 675–680
Dane D, Cameron C, Biggs M (1970) Virus like particles in serum of patients with Australia antigen associated hepatitis. Lancet 1: 695–698
Galle P, Schlicht HJ, Fischer M, Schaller H (1988) Production of infectious duck hepatitis B virus in a human hepatoma cell line. J Virol 62: 1736–1740
Ganem D, Varmus H (1987) The molecular biology of the hepatitis-B viruses. Ann. Rev. Biochem. 56: 651–693
Hoofnagle J, Shafritz D, Popper H (1987) Chronic type B hepatitis and the “healthy” HBsAg carrier state. Hepatology 7: 758–763
Junker M, Galle P, Schaller H (1987) Expression and replication of the hepatitis-B virus genome under foreign promoter control Nucleic Acids Res 15: 10117–10132
Linial M (1987) Creation of a processed pseudogene by retroviral infection. Cell 49: 93–102
Nagaya T, Nakamura T, Tokino T, Tsurimoto T, Imai M, Mayumi T, Kamino K, Yamamura K, Matsubara K (1987) The mode of hepatitis B virus DNA integration in chromosomes of human hepatocellular carcinoma. Genes and Development 1: 773–782
Popper H, Shafritz D, Hoofnagle J (1987 a) Relation of the hepatitis B virus carrier state to hepatocellular carcinoma. Hepatology 7: 764–772
Popper H, Roth L, Purcell R, Tennant B, Gerin J (1987 b) Hepatocarcinogenicity of the wood-chuck hepatitis virus. Proc Natl Acad Sci USA 84: 866–870
Schlicht HJ, Galle P, Schaller H (1987 a) The hepatitis B viruses: molecular biology and recent tissue culture systems J Cell Sci [Suppl] 7: 197–212
Schlicht HJ, Salfeld J, Schaller H (1987 b) The pre-C region of the duck hepatitis-B virus is essential for synthesis and secretion of processed core proteins but not for virus formation. J Virol 61: 3701–3709
Schlicht HJ, Radziwill G, Schaller H (1989) Synthesis and encapsidation of duck hepatitis B virus reverse transcriptase do not require formation of core polymerase fusion proteins. Cell 56: 85–92
Spandau D, Lee C (1988) trans-Activation of viral enhancers by the hepatitis B virus X protein. J Virol 62: 427–434
Sprengel R, Kuhn C, Will H, Schaller H (1985) Comparative sequence analysis of duck and human hepatitis-B virus genomes. J Med Virol 15: 323–333
Summers J, Smolec J, Snyder R (1978) A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks. Proc Natl Acad Sci USA 75: 4533–4537
Sureau C, Roup-Lemonne J, Mullins J, Essex M (1986) Production of hepatitis B virus by a differentiated human hepatoma cell line after transfection with cloned circular HBV DNA. Cell 47: 37–47
Tsurimoto T, Fujiyama A, Matsubara K (1987) Stable expression and replication of hepatitis B virus genome in an integrated state in a human hepatoma cell line transfected with the cloned viral DNA. Proc Natl Acad Sci USA 84: 444–448
Tuttleman J, Pugh J, Summers J (1986) In vitro experimental infection of primary duck hepatocyte cultures with duck hepatitis-B virus. J Virol 58: 17–25
Will H, Cattaneo R, Koch H, Darai G, Schaller H, Schellekens P, van Eerd C, Deinhardt F (1982) Cloned HBV DNA causes hepatitis in chimpanzees. Nature (London) 299: 740–741
Will H, Cattaneo R, Darai G, Deinhardt F, Schellekens H, Schaller H (1985) Infectious hepatitis B virus from cloned DNA of known nucleotide sequence. Proc Natl Acad Sci USA 82: 891–895
Yaginuma K, Shirakata Y, Kobayashi M, Koike K (1987) Hepatitis B virus (HBV) particles are produced in a cell culture system by transient expression of transfected HBV DNA. Proc Natl Acad Sci USA 84: 2678–2682
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© 1989 Springer-Verlag Berlin · Heidelberg
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Schlicht, HJ., Schaller, H. (1989). Analysis of Hepatitis B Virus Gene Functions in Tissue Culture and In Vivo. In: Knippers, R., Levine, A.J. (eds) Transforming Proteins of DNA Tumor Viruses. Current Topics in Microbiology and Immunology, vol 144. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74578-2_32
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DOI: https://doi.org/10.1007/978-3-642-74578-2_32
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