Abstract
The transforming activity of SV40 large T antigen is due to the ability of this protein to interfere with and modify a variety of cellular regulatory processes (Tooze 1981). Cellular proto-oncogene products have been shown to play key roles in such normal processes (Weinberg 1985; Bishop 1987). It is thus conceivable that SV40-mediated transformation may both affect the functioning of certain proto-oncogenes and, reciprocally, be influenced by the particular proto-oncogene expression patterns and oncogene activation events present in various cells. In order to gain further insight into this aspect of large T-antigen action, we investigated the ability of specific activated cellular oncogenes to play a role in SV40-mediated transformation. The studies described below demonstrate that such cellular proteins may indeed dramatically affect the ability of SV40 to cause transformation. Furthermore, the aberrant expression of cellular oncogenes may greatly influence the biochemical and physiological consequences of large T-antigen action in the transformed cell.
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© 1989 Springer-Verlag Berlin · Heidelberg
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Michalovitz, D., Amsterdam, A., Oren, M. (1989). Interactions Between SV40 and Cellular Oncogenes in the Transformation of Primary Rat Cells. In: Knippers, R., Levine, A.J. (eds) Transforming Proteins of DNA Tumor Viruses. Current Topics in Microbiology and Immunology, vol 144. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74578-2_8
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DOI: https://doi.org/10.1007/978-3-642-74578-2_8
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