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Blutung, Schock und Sepsis

  • Conference paper
Gynäkologie und Geburtshilfe 1988

Summary

Hemorrhage and sepsis may lead to multiple organ system failure caused by a redistribution of cardiac output and a reduction of tissue perfusion. The pathophysiologic changes caused by hemorrhage are frequently prevented by rapid diagnosis of the cause of the bleeding (e.g., vessel injury or coagulation disorder) and its therapy. The pathophysiologic changes in sepsis are mediated by toxins which affect almost every organ system. Knowledge of the predisposing factors, rapid recognition of signs and symptoms, and understanding of the underlying pathobiochemical and pathophysiologic changes are mandatory in the successful therapy of septic shock. The main therapeutic principle remains removal of the focus.

Zusammenfassung

Blutung und Sepsis können durch Fehlverteilung des Herz-zeitvolumens mit Reduktion der Gewebeperfusion zu einem Multiorganversagen führen. Die pathophysiologischen Veränderungen der Blutung können dabei durch rechtzeitiges Erkennen der Blutungsursache (Blutung infolge Gefäßverletzung, Gerinnungsstörung) und deren Beseitigung meist behoben werden. Die pathophysiologischen Veränderungen der Sepsis werden durch Toxine hervorgerufen, deren mediatorvermittelte, kaskadenartige Wirkung nahezu alle Organsysteme des Körpers beeinflußt. Das Wissen um prädisponierende Faktoren für die Entwicklung dieses Krankheitsbildes, rechtzeitiges Erkennen der Zeichen und Symptome, Verständnis der pathobiochemischen und pathophysiologischen Veränderungen sind unabdingbar für eine erfolgreiche Therapie des septischen Schocks, deren Schwerpunkt die Herdsanierung ist.

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Authors and Affiliations

  1. Frauenklinik und Poliklinik, Technischen Universität rechts der Isar, München, Deutschland

    H. Graeff & R. Deckardt

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  1. H. Graeff
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  2. R. Deckardt
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Editors and Affiliations

  1. Universitäts-Frauenklinik, Schanzenstr. 46, CH-4031, Basel, Schweiz

    Hans Ludwig

  2. Universitäts-Frauenklinik, Sigmund-Freud-Str. 25, D-5300, Bonn 1, Bundesrepublik Deutschland

    Dieter Krebs

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© 1989 Springer-Verlag Berlin Heidelberg

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Graeff, H., Deckardt, R. (1989). Blutung, Schock und Sepsis. In: Ludwig, H., Krebs, D. (eds) Gynäkologie und Geburtshilfe 1988. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74784-7_427

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  • DOI: https://doi.org/10.1007/978-3-642-74784-7_427

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74785-4

  • Online ISBN: 978-3-642-74784-7

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