Abstract
Ionizing radiation is known to damage DNA by a variety of mechanisms, some or all of which may be responsible for damage induced in the DNA of mammalian cells. Strong evidence points to the significance of DNA damage as the source of the biological consequences of ionizing radiation (Makrigiorgos et al. 1990, Painter 1979, Ward 1988). There are two major reasons for understanding all the chemical reactions which lead to DNA damage in a cell (and to identify those which do not contribute): This knowledge can serve as a basis for predicting the shapes and slopes of yield dose curves for biological effects at low doses and with different radiations, and, it can permit rational approaches to improvements in radiotherapy protocols. Thus it is important that a. reactions which actually occur in vivo be delineated, and b. the damage which causes the biological effects be defined. The overall scenario which is developed should be capable of explaining variations in cellular radiosensitivity caused by radiations of different LET, different oxygen concentrations, and the effects of sensitizers and protectors.
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Ward, J.F. (1991). Mechanisms of Radiation Action on DNA in Model Systems - Their Relevance to Cellular DNA. In: Fielden, E.M., O’Neill, P. (eds) The Early Effects of Radiation on DNA. NATO ASI Series, vol 54. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75148-6_1
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DOI: https://doi.org/10.1007/978-3-642-75148-6_1
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