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Retroviral Proteinases

  • Conference paper
Retroviruses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 157))

Abstract

Limited proteolysis is a well-established posttranslational mechanism by which cellular and viral precursor proteins are cleaved by specific proteinases into functional species (Koch and (Richter 1980). Examples of such cellular proteins are the neuropolypeptide prohormones (Mains et al. 1983) and propiocortin, while the best known viral polyproteins are the polio (Summers and Maizel 1968; Jacobson and Baltimore 1968) and retroviral gag and gag-pol encoded polyproteins (Dickson et al. 1984). Two recent reviews during the past year have focused on viral proteinases coded for by positive-strand RNA viruses e.g., picorna and toga-flavivirus families (Kräusslich and Wimmer 1988), or by plant viruses (Wellink and van Kammen 1988). The focus of this review will be on a discussion of the biochemical properties as well as functions of retroviral proteinases (PR). These enzymes cleave both gag and gag-pol encoded polyproteins (cleavage of the env encoded polyprotein occurs via a cellular Golgilocalized enzyme).

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Authors and Affiliations

  1. Laboratory of Molecular Virology and Carcinogenesis, BRI-Basic Research Program, NCI-Frederick Cancer Research Facility, Frederick, MD, 21701, USA

    S. Oroszlan & R. B. Luftig

  2. Department of Microbiology, Immunology and Parasitology, Louisiana State Medical School, 1901 Perdido St., New Orleans, LA, 70112-1393, USA

    S. Oroszlan & R. B. Luftig

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  1. S. Oroszlan
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  2. R. B. Luftig
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Editors and Affiliations

  1. Dept. of Biochemistry, Lineberger Cancer Research Ctr., University of North Carolina at Chapel Hill, CB #7295, 246 Lineberger Bldg., Chapel Hill, NC, 27599, USA

    Ronald Swanstrom Ph.D. (Associate Professor of Biochemistry) (Associate Professor of Biochemistry)

  2. Dept. of Microbiology, School of Medicine, University of Southern California, 2011 Zone Avenue HMR 401, Los Angeles, CA, 90033, USA

    Peter K. Vogt M.D.

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© 1990 Springer-Verlag Berlin · Heidelberg

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Oroszlan, S., Luftig, R.B. (1990). Retroviral Proteinases. In: Swanstrom, R., Vogt, P.K. (eds) Retroviruses. Current Topics in Microbiology and Immunology, vol 157. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75218-6_6

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  • DOI: https://doi.org/10.1007/978-3-642-75218-6_6

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