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Substances with an Antiallergic Effect

  • Chapter
Immunopharmacology

Abstract

Immediate-type hypersensitivity is the hallmark of any allergic reaction. It develops when contact with a specific antigen triggers the formation of IgE antibodies which bind to the Fcɛ receptors of mast cells or basophilic leucocytes. Renewed contact with the same antigen then leads to “bridging”: adjacent antibodies on the cell surface are interconnected by antigen molecules through their antigen-binding portions. At the Fc receptor the antigen-antibody reaction gives rise to a signal that passes through a chain of biochemical reactions which will be described below in some detail. Eventually the signal leads to the release of mediators from the granules of mast cells and basophilic leucocytes.

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References

  • Goldberg ME (ed) (1981): Pharmacological and biochemical properties of drug substances, Vol 3, Published by: American Pharmaceutical Association, Academy of Pharmaceutical Sciences.

    Google Scholar 

  • Ishizaka K (1988): IgE-binding factors and regulation of the IgE antibody response. Ann Rev Immunol, Vol 6, 513–534.

    Article  CAS  Google Scholar 

  • Morley J (1982): Bronchial hyperreactivity. Academic Press, London, New York, Paris, San Diego, San Francisco, São Paulo, Sydney, Tokyo, Toronto.

    Google Scholar 

  • Oppenheim JJ, Rosenstreich DL, Potter M (eds) (1984): Cellular functions in immunity and inflammation. Elsevier/North Holland, New York, Amsterdam.

    Google Scholar 

  • Parker W (1982): Allergic reactions in man. Pharmacological Reviews, Vol 34, No 1, 85–104.

    PubMed  CAS  Google Scholar 

  • Wilson JD (1983): Asthma and allergic diseases: A clinician’s guide to diagnosis and management. ADIS Health Science Press, Sydney, Auckland, Bristol, Boston, Hong Kong, Tokyo.

    Google Scholar 

  • Akasaki M, Jardieu P, Ishizaka K (1986): Immunosuppressive effects of glycosylation inhibiting factor on the IgE and IgG antibody response. The Journal of Immunology, Vol 136, No 9, 3172– 3179.

    Google Scholar 

  • Aim PE (1984): Modulation of mast cell cAMP levels. Int Arch Allergy Appl Immun, Vol 75, 375–378.

    Article  Google Scholar 

  • Alt FW, Blackwell TK, Yancopoulos GD (1987): Development of the primary antibody repertoire. Science, Vol 238, 1079–1087.

    Article  PubMed  CAS  Google Scholar 

  • Askenase PW, Schwartz A, Siegel JN, Gershon RK (1981): Role of histamine in the regulation of cell mediated immunity. Int Arch Allergy Appl Immun, Vol 66 (Suppl 1), 225–233.

    Article  CAS  Google Scholar 

  • Azuma M, Hirano T, Miyajima H, Watanabe N, Yagita H, Enomoto S, Furusawa S, Ovary Z, Kinashi T, Honjo T, Okumura K (1987): Regulation of murine IgE production in SJA/9 and nude mice. Potentiation of IgE production by recombinant interleukin 4. The Journal of Immunology, Vol 139, No 8, 2538 - 2544.

    PubMed  CAS  Google Scholar 

  • Balch CM, Dougherty PA, Cloud GA, Tilden AB (1983): Prostaglandin E2-mediated suppression of cellular immunity in colon cancer patients. Surgery, Vol 92, No 1, 72–77.

    Google Scholar 

  • Batchelor JR, McMichael J (1987): Progress in understanding HLA and disease associations. British Medical Bulletin, Vol 43, No 1, 156–183.

    PubMed  CAS  Google Scholar 

  • Beaven MA, Moore JP, Smith GA, Hesketh TR, Metcalfe JC (1983): The calcium signal and phosphatidylinositol breakdown in 2H3 cells. The Journal of Biological Chemistry, Vol 259, 7137– 7142.

    Google Scholar 

  • Befus D (1987): The role of the mast cell in allergic bronchospasm. Can J Physiol Pharmacol, Vol 65, 435–441.

    Article  PubMed  CAS  Google Scholar 

  • Bernstein IL (1981): Cromolyn sodium in the treatment of asthma: Changing concepts. J Allergy Clin Immunol, Vol 68, No 4, 247–253.

    Article  PubMed  CAS  Google Scholar 

  • Berridge MJ, Irvine RF (1984): Inositol triphosphate, a novel second messenger in cellular signal transduction. Nature, Vol 312, 315–321.

    Article  PubMed  CAS  Google Scholar 

  • Bonney RJ, Humes JL (1984): Physiological and pharmacological regulation of prostaglandin and leukotriene production by macrophages. Journal of Leukocyte Biology, Vol 35, 1–10.

    PubMed  CAS  Google Scholar 

  • Bottomly K (1988): A functional dichotomy in CD4 + T lymphocytes. Immunology Today, Vol 9, No 9, 268–274.

    Article  PubMed  CAS  Google Scholar 

  • Bunting S, Moncada S, Vane JR (1983): The prostacyclin-thromboxane A2 balance: pathophysio-logical and therapeutic implications. British Medical Bulletin, Vol 39, No 3, 271–276.

    PubMed  CAS  Google Scholar 

  • Craps LP (1985): Immunologic and therapeutic aspects of ketotifen. J Allergy Clin Immunol, Vol 76, 389–393.

    Article  PubMed  CAS  Google Scholar 

  • Craps LP (1985): Ketotifen: Highlights in Asthmology. Springer, Heidelberg. Berlin, New York.

    Google Scholar 

  • Craps LP, Greenwood C, Ney UM (1985): Ketotifen and asthma. In: Bronchial-Asthma-Me- chanisms and Therapeutics, 2nd edition ( Weiss EB, Segal MS, Stein M, eds). Little, Brown and Co, Boston, Mass, 734–740.

    Google Scholar 

  • Craps LP, Ney UM (1984): Ketotifen: Current views on its mechanism of action and their therapeutic implications. Respiration, Vol 45, 411–421.

    Article  PubMed  CAS  Google Scholar 

  • Davies RJ, Moodley I (1982): Antiallergic compounds. Pharmac Ther, Vol 17, 279–297.

    Article  CAS  Google Scholar 

  • Deguchi H, Suemura M, Ishizaka A, Ozaki Y, Kishimoto S, Yamamura Y, Kishimoto T (1983): Immunoglobulin E class specific suppressor T cells and factors in humans. The Journal of Immunology, Vol 131 (6), 2751–2756.

    PubMed  CAS  Google Scholar 

  • Delespesse G, Sarfati M, Hofstetter H (1989): Human IgE-binding factors. Immunology Today, Vol 10, No 5, 159–164.

    Article  PubMed  CAS  Google Scholar 

  • Delespesse G, Sarfati M, Peleman R (1989): Influence of recombinant IL-4, IFN-a, and IFN-y on the production of human IgE-binding factor (soluble CD23). The Journal of Immunology, Vol 142, No 1, 134–138.

    PubMed  CAS  Google Scholar 

  • Delespesse G, Sarfati M, Hofstetter H, Frost H, Kilchherr E, Suter U (1989): Human FCER II and IgE-binding factors. Int Arch Allergy Appl Immun, Vol 88, 18–22.

    CAS  Google Scholar 

  • Diamant B (1982): Histamine secretion: Research in retrospect. Agents and Actions. Vol 12, 1 /2, 5–11.

    Article  PubMed  CAS  Google Scholar 

  • Eiser NM (1982): Histamine antagonists and asthma. Pharmac Ther, Vol 17, 239–250.

    Article  CAS  Google Scholar 

  • Esser C, Radbruch A (1989): Rapid induction of transcription of unrearranged sy 1 switch regions in activated murine B cells by interleukin 4. The EMBO Journal, Vol 8, No 2, 483–488.

    PubMed  CAS  Google Scholar 

  • Fernandez JM, Neher E, Gomperts BD (1984): Capacitance measurements reveal stepwise fusion events in degranulating mast cells. Nature, Vol 312, 29 November 1984, 453–454.

    Article  PubMed  CAS  Google Scholar 

  • Finkelman FD, Katona IM, Mosmann TR, Coffman RL (1988): IFN-y regulates the isotypes of Ig secreted during in vivo humoral immune responses. The Journal of Immunology, Vol 140, No 4, 1022–1027.

    PubMed  CAS  Google Scholar 

  • Finkelman FD, Katona IM, Urban JF Jr, Holmes J, Ohara J, Tung AS, Sample J, Paul WE (1988): IL–4 is required to generate and sustain in vivo IgE responses. The Journal of Immunology, Vol 141, No 7, 2335–2341.

    PubMed  CAS  Google Scholar 

  • Galizzi J-P, Cabrillat H, Rousset F, Ménétrier C, de Vries JE, Banchereau J (1988): IFN-y and prostaglandin E2 inhibit IL-4 induced expression of FceR2/CD23 on B lymphocytes through different mechanisms without altering binding of IL-4 to its receptor. The Journal of Immunology, Vol 141, No 6, 1982–1988.

    Google Scholar 

  • Geha RS (1988): Regulation of IgE synthesis in atopic disease. Hospital Practice, Vol 23, No 2, 91–102.

    PubMed  CAS  Google Scholar 

  • Gemsa D, Deimann W, Bärlin E, Seitz M, Leser H-G (1982): Die Rolle von Prostaglandinen aus Makrophagen bei Regulation und Suppression der Immunantwort. Allergologie, Jahrgang 5, Nr 4, 142–150.

    CAS  Google Scholar 

  • Gigl G, Hartweg D, Sanchez-Delgado E, Metz G, Gietzen K (1987): Calmodulin antagonism: A pharmacological approach for the inhibition of mediator release from mast cells. Cell Calcium, Vol 8, 327–344.

    Article  PubMed  CAS  Google Scholar 

  • Gleich JG, Adolphson CR (1986): The eosinophilic leukocyte: Structure and function. Advances in Immunology, Vol 39, 177–253.

    Article  PubMed  CAS  Google Scholar 

  • Goetzl EJ, Payan DG, Goldman DW (1984): Immunopathogenetic roles of leukotrienes in human diseases. Journal of Clinical Immunology, Vol 4, No 2, 79–84.

    Article  PubMed  CAS  Google Scholar 

  • Gomperts BD (1983): Involvement of guanine nucleotide-binding protein in the gating of Ca2+ by receptors. Nature, Vol 306, 3 November 1983, 64–66.

    Article  PubMed  CAS  Google Scholar 

  • Goodwin JS, Ceuppens J (1983): Regulation of the immune response by prostaglandins. Journal of Clinical Immunology, Vol 3, No 4, 295 - 315.

    Article  PubMed  CAS  Google Scholar 

  • Gordon J, Flores-Romo L, Cairns JA, Millsum MJ, Lane PJ, Johnson GD, MacLennan I CM (1989): CD23: a multi-functional receptor/lymphokine? Immunology Today, Vol 10, No 5, 153–157.

    Article  PubMed  CAS  Google Scholar 

  • Hamann KJ, Barker RL, Loegering DA, Gleich GJ (1987): Comparative toxicity of purified human eosinophil granule proteins for newborn larvae of Trichinella spiralis. J Parasitol, Vol 73, No 3, 523 – 529.

    Article  PubMed  CAS  Google Scholar 

  • Hansel TT (1987): Leucocyte typing — OKCD? Lancet Dec 12, 1382–1383.

    Article  Google Scholar 

  • Hansen BL (1986): Why do some individuals produce autoreactive antibodies against receptors and/or their ligands? A possible answer to the question. A review with implications. Scand J Immunol, Vol 24, 363–370.

    Article  PubMed  CAS  Google Scholar 

  • Hanson JM, Rumjanek VM, Morley J (1982): Mediators of cellular immune reactions. Pharmac Ther, Vol 17, 165–198.

    Google Scholar 

  • Hassner A, Saxon A (1984): Isotype specific human suppressor T cells for immunoglobulin E synthesis activated by immunoglobulin E antiimmunoglobulin E immune complexes. The Journal of Immunology, Vol 132 (6), 2844–2849.

    PubMed  CAS  Google Scholar 

  • Huff TF, Yodoi J, Uede T, Ishizaka K (1984): Presence of an antigenic determinant common to rat IgE-potentiating factor, IgE-suppressive factor, and Fc£ receptors on T and B lymphocytes. The Journal of Immunology, Vol 132, No 1, 406–412.

    PubMed  CAS  Google Scholar 

  • Ishizaka K, Jardieu P, Akasaki M, Iwata M (1987): T cell factors involved in the regulation of the IgE synthesis. Int Arch Allergy Appl Immun, Vol 82, 383–388.

    Article  CAS  Google Scholar 

  • Ishizuka Y, Imai A, Nakashima S, Nozawa Y (1983): Evidence for de novo synthesis of phosphati- dylinositol coupled with histamine release in activated rat mast cells. Biochemical and Biophysical Research Communications, Vol 111, No 2, 581–587.

    Article  PubMed  CAS  Google Scholar 

  • Iwata M, Adachi M, Ishizaka K (1988): Antigen-specific T cells that form IgE-potentiating factor. IgG-potentiating factor, and antigen-specific glycosylation-enhancing factor on antigenic stimulation. The Journal of Immunology, Vol 140, No 8, 2534–2542.

    PubMed  CAS  Google Scholar 

  • Iwata M, Akasaki M, Ishizaka K (1984): Modulation of the biologic activities of IgE-binding factor. VI. The activation of phospholipase by glycosylation enhancing factor. The Journal of Immunology, Vol 133, No 3, 1505–1512.

    PubMed  CAS  Google Scholar 

  • Iwata M, Fukutomi Y, Hashimoto T, Sato Y, Sato H, Ishizaka K (1987): Augmentation of the antibody response by antigen-specific glycosylation-enhancing factor. The Journal of Immunology, Vol 138, No 8, 2561–2567.

    PubMed  CAS  Google Scholar 

  • Iwata M, Huff TF, Ishizaka K (1984): Modulation of the biologic activities of IgE-binding factor. V. The role of glycosylation-enhancing factor and glycosylation-inhibiting factor in determining the nature of IgE-binding factors. The Journal of Immunology, Vol 132, No 3, 1286–1293.

    PubMed  CAS  Google Scholar 

  • James MP, Kennedy AR, Eady RAJ (1982): A microscopic study of inflammatory reactions in human skin induced by histamine and compound 48/80. J Investig Dermatol, Vol 78, No 5, 406– 413.

    Google Scholar 

  • Jardieu P, Uede T, Ishizaka K (1984): IgE-binding factors from mouse T lymphocytes. III. Role of antigen-specific suppressor T-cells in the formation of IgE-suppressive factor. The Journal of Immunology, Vol 133, No 6, 3266–3273.

    PubMed  CAS  Google Scholar 

  • Joly F, Bessou G, Benveniste J, Ninio E (1987): Ketotifen inhibits paf-acether biosynthesis and hexosaminidase release in mouse mast cells stimulated with antigen. European Journal of Pharmacology, Vol 144, 133–139.

    Google Scholar 

  • Kanowith-Klein S, Saxon A (1986): Regulation of ongoing IgE synthesis by human T-cell superna- tants derived from atopic and nonatopic donors. Int Arch Allergy Appl Immun, Vol 80, 33–38.

    Article  CAS  Google Scholar 

  • Katz DH (1984): Regulation of the IgE system: Experimental and clinical aspects. Allergy, Vol 39, 81–106.

    Article  PubMed  CAS  Google Scholar 

  • Katz DH, Chen S-S, Liu F-T, Bogowitz CA, Katz LR (1984): Biologically active molecules regulating the immunoglobulin E antibody system, biochemical and biological comparisons of suppressive factor of allergy and enhancing factor of allergy. J Mol Cell Immunol, Vol 1 (3), 157–166.

    PubMed  CAS  Google Scholar 

  • Kennerly DA (1987): Preparation and characterization of mast cell cytoplasts. J Immunol Meth, Vol 97, 173–183.

    Article  CAS  Google Scholar 

  • Kikutani H, Inui S, Sato R, Barsumian EL, Owaki H, Yamasaki K, Kaisho T, Uchibayashi N, Hardy RR, Hirano T, Tsunasawa S, Sakiyama F, Suemura M, Kishimoto T (1986): Molecular structure of human lymphocyte receptor for immunoglobulin E. Cell, Vol 47, 657–665.

    Article  PubMed  CAS  Google Scholar 

  • König W, Pfeil P, Hofmann U, Bujanowski-Weber J, Knöller I (1987): Cellular requirements of IgE-antibody regulation. Path Biol, Vol 35, No 10, 1440–1445.

    Google Scholar 

  • Kosaka Y, Kawabe H, Ishii A (1987): Oxatomide inhibits the release of bronchoconstrictor arachidonic acid metabolites (LTC4 and PGD2) from rat mast cells and guinea-pig lung. Agents and Actions, Vol 21, 32–37.

    Google Scholar 

  • Kraemer MJ, Ochs HD, Furukawa CT, Wedgwood RJ (1982): In-vitro studies of the hyperimmuno- globulin-E disorders: Suppression of spontaneous immunoglobulin E synthesis by allogeneic suppressor T lymphocytes. Clin Immunol Immunopathol, Vol 25 (2), 157–164.

    CAS  Google Scholar 

  • Kuriyama K, Hiyama Y, Nagatahira R, Okuda T, Saito K, Ito K (1986): An antiallergic activity of disodium cromoglycate unrelated to mast cell activation. Agents and Actions, Vol 18, 473–478.

    Article  Google Scholar 

  • Lagunoff D, Martin TW, Read G (1983): Agents that release histamine from mast cells. Ann Rev Pharmacol Toxicol, Vol 23, 331–351.

    Article  CAS  Google Scholar 

  • Leung DYM, Brozek C, Frankel R, Geha RS (1984): IgE-specific suppressor factors in normal human serum. Clin Immunol Immunopathol, Vol 32 (3), 339–350.

    Article  PubMed  CAS  Google Scholar 

  • Leung DYM, Geha RS (1984): Regulation of IgE synthesis in man. Clinical Immunology Reviews, Vol 3 (1), 1–24.

    PubMed  CAS  Google Scholar 

  • Lim LK, Hunt NH, Eichner RD, Weidemann MJ (1983): Cyclic AMP and the regulation of prostaglandin production by macrophages. Biochemical and Biophysical Research Communications, Vol 114, No 1, 248–254.

    Article  PubMed  CAS  Google Scholar 

  • Lutzker S, Rothman P, Pollock R, Coffman R, Alt FW (1988): Mitogen- and Il-4-regulated expression of germ-line Ig y2b transcripts: Evidence for directed heavy chain class switching. Cell, Vol 53, 177–184.

    Article  PubMed  CAS  Google Scholar 

  • Maggi E, Del Prete GF, Tiri A, Macchia D, Parronchi P, Ricci M, Romagnani S (1987): Role of interleukin-4 in the induction of human IgE synthesis and its suppression by interferon-y. La Ricerca Clin Lab, Vol 17, No 4, 363–367.

    CAS  Google Scholar 

  • Martens CL, Jardieu P, Trounstine ML, Stuart SG, Ishizaka K, Moore KW (1987): Potentiating and suppressive IgE-binding factors are expressed by a single cloned gene. Proc Natl Acad Sci USA, Vol 84, 809–813.

    Article  PubMed  CAS  Google Scholar 

  • Mazurek N, Schindler H, Schürholz T, Pecht I (1984): The cromolyn binding protein constitutes the Ca2+ channel of basophils opening upon immunological stimulus. Proc Natl Acad Sci USA, Vol 81, 6841–6845.

    Article  PubMed  CAS  Google Scholar 

  • Nishizuka Y (1984): The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature, Vol 308, 19 April 1984, 693–698.

    Article  PubMed  CAS  Google Scholar 

  • Norn S, Stahlskov P, Kock C, Andersen P, Pedersen M, Tonnesen P, Pedersen PS, Moller NE, Hertz J, Hoiby N (1982): Intrinsic asthma and bacterial histamine release. Agents and Actions, Vol 12, 1/2, 101–102. 5

    Article  Google Scholar 

  • Owen WF, Rothenberg ME, Silberstein DS, Gasson JC, Stevens RL, Austen FK, Soberman RJ (1987): Regulation of human eosinophil viability, density, and function by granulocyte/macrophage colony-stimulating factor in the presence of 3T3 fibroblasts. J Exp Med, Vol 166, 129–141.

    Article  PubMed  CAS  Google Scholar 

  • Pardoll DM, Kruisbeek AM, Fowlkes BJ, Coligan JE, Schwartz RH (1987): The unfolding story of T-cell receptor gamma. FASEBJ, Vol 1, 103–109.

    CAS  Google Scholar 

  • Pelikan Z (1982): The effects of disodium chromoglycate and beclomethasone dipropionate on the late nasal mucosa response to allergen challenge. Annals of Allergy, Vol 49 (4), 200–212.

    PubMed  CAS  Google Scholar 

  • Pêne J, Rousset F, Brière F, Chrétien I, Bonnefoy J-Y, Spits H, Yokota T, Arai N, Arai K-I, Banchereau J (1988): IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons y and a and prostaglandin E2. Proc Natl Acad Sci USA, Immunology, Vol 85, 6880–6884.

    Article  PubMed  Google Scholar 

  • Pincus SH, Whitcomb EA, Dinarello CA (1986): Interaction of 11-1 and TP A in modulation of eosinophil function. The Journal of Immunology, Vol 137, 3509–3514.

    Google Scholar 

  • Piper PJ (1983): Pharmacology of leukotrienes. British Medical Bulletin, Vol 39, No 3, 255–259.

    PubMed  CAS  Google Scholar 

  • Ray A, Hemady Z, Rocklin RE (1987): Glucoeorticoid-induced enhancement of IgE synthesis. New England and Regional Allergy Proceedings, Vol 8, No 2, 81–84.

    Article  PubMed  CAS  Google Scholar 

  • Resta O, Barbaro MPF, Carnimeo N (1982): A comparison of sodium chromo-glycate nasal solution and powder in the treatment of allergic rhinitis. The British Journal of Clinical Practice, Vol 36, No 3, 94–98.

    Google Scholar 

  • Riccardi VM (1987): Mast-cell stabilization to decrease neurofibroma growth. Arch Dermatol, Vol 123, 1011–1016.

    Article  PubMed  CAS  Google Scholar 

  • Rocklin RE (1983): Clinical and immunologic aspects of allergen-specific immunotherapy in patients with seasonal allergic rhinitis and/or allergic asthma. J Allergy Clin Immunol, Vol 72, No 4, October 1983.

    Google Scholar 

  • Rocklin RE, Beer DJ (1983): Histamine and immune modulation. Advances in Internal Medicine, Vol 28, 225–251. In: 1983, Year Book Medical Publishers, Inc.

    Google Scholar 

  • Romagnani S, Del Prete G, Maggi E, Ricci M (1987): Activation through CD3 molecule leads a number of human T cell clones to induce IgE synthesis in vitro by B cells from allergic and nonallergic individuals. The Journal of Immunology, Vol 138, No 6, 1744–1749.

    PubMed  CAS  Google Scholar 

  • Rothman P, Lutzker S, Cook W, Coffman R, Alt FW (1988): Mitogen plus interleukin 4 induction of Ce transcripts in B lymphoid cells. J Exp Med, Vol 168, 2385–2389.

    Google Scholar 

  • Sagi-Eisenberg R, Lieman H, Pecht I (1985): Protein kinase C regulation of the receptor-coupled calcium signal in histamine-secreting rat basophilic leukaemia cells. Nature, Vol 313, 59–60.

    Google Scholar 

  • Sampson HA (1983): Prospects for control of the IgE antibody response. Pediatric Clinics of North America, Vol 30, No 5, 773–785.

    PubMed  CAS  Google Scholar 

  • Schild HO (1981): The multiple tacets of histamine research. Agents and Actions, Vol 11, 1 /2, 12–19.

    Article  PubMed  CAS  Google Scholar 

  • Schnitzler S, Eckert R, Volk D, Grunow R (1982): Histamin und Immunreaktionen. Allergie u Immunol, Vol 28, 219–235.

    Google Scholar 

  • Schwartz LB, Bradford TR, Irani AA, Deblois G, Craig SS (1987): The major enzymes of human mast cell secretory granules. Am Rev Respir Dis, Vol 135, 1186–1189.

    Google Scholar 

  • Snapper CM, Finkelman FD, Paul WE (1988): Differential regulation of IgGl and IgE synthesis by interleukin 4. J Exp Med, Vol 167, 183–196.

    Google Scholar 

  • Snapper CM, Paul WE (1988): The role of lymphokines in the immunoglobulin class switch. Lymphocyte Activation and Differentiation, Walter de Gruyter & Co., Berlin, New York, 83–95.

    Google Scholar 

  • Sullivan KE, Caiman AF, Nakanishi M, Tsang SY, Wang Y, Peterlin BM (1987): A model for the transcriptional regulation of MHC class II genes. Immunology Today, Vol 8, No 10, 289–293.

    Article  CAS  Google Scholar 

  • Tasaka K, Mio M, Okamoto M (1986): Intracellular calcium release induced by histamine releasers and its inhibition by some antiallergic drugs. Annals of Allergy, Vol 56, 464–469.

    Google Scholar 

  • Todd III RF, Liu DY (1986): Mononuclear phagocyte activation: Activation-associated antigens. Federation Proc, Vol 45, 2829–2836.

    Google Scholar 

  • Tomilets VA (1982); Role of cyclic nucleotides in the immunomodulating action of histamine in mice. Bullet Experim Biol and Medicine, Vol 93, No 6, 79–80.

    CAS  Google Scholar 

  • Uede T, Huff TF, Ishizaka K (1984): Suppression of IgE synthesis in mouse plasma cells and B cells by rat IgE–suppressive factor. The Journal of Immunology, Vol 133, No 2, 803–808.

    PubMed  CAS  Google Scholar 

  • Uede T, Ishizaka K (1984): IgE-binding factors from mouse T lymphocytes. II. Strain differences in the nature of IgE-binding factor. The Journal of Immunology, Vol 133, No 1, 359–367.

    PubMed  CAS  Google Scholar 

  • Unanue ER, Allen PM (1987): The basis for the immunoregulatory role of macrophages and other accessory cells. Science, Vol 236, 551–557.

    Google Scholar 

  • Vercelli D, Jabara HH, Arai K-I, Geha RS (1989): Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC class II antigens. J Exp Med, Vol 169, 1295–1307.

    Google Scholar 

  • Volpi M, Yassin R, Naccache PH, Sha’afi RI (1983): Chemotactic factor causes rapid decreases in phosphatidylinositol, 4,5-bisphosphate and phosphatidylinositol 4-monophosphate in rabbit neutrophils. Biochemical and Biophysical Research Communications, Vol 112, No 3, 957–964.

    Article  PubMed  CAS  Google Scholar 

  • Wasmoen TL, Bernischke K, Gleich GJ (1987): Demonstration of immunoreactive eosinophil granulae major basic protein in the plasma and placentae of non-human primates. Placenta, Vol 8, 283–292.

    Google Scholar 

  • Yanagihara Y, Kajiwara K, Kiniwa M, Kamisaki T, Yui Y, Shida T, Delespesse G (1987): Modulation of IgE synthesis by IgE-binding factors released by T cells of asthmatic patients with elevated serum IgE. Microbiol Immunol, Vol 31, 261–274.

    Google Scholar 

  • Yokota A, Kikutani H, Tanaka T, Sato R, Barsumian EL, Suemura M, Kishimoto T (1988): Two species of human FCE receptor II (FEE RII/CD23): Tissue-specific and IL-4-specific regulation of gene expression. Cell, Vol 55, 611–618.

    Article  PubMed  CAS  Google Scholar 

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    Professor Jürgen Drews MD (Chairman of the Research Board and Member of the Executive Committee)

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Drews, J. (1990). Substances with an Antiallergic Effect. In: Immunopharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75561-3_5

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