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The Enzymology of Poxvirus DNA Replication

  • Conference paper
Poxviruses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 163))

Abstract

DNA replication is arguably the most fundamental of biological processes and serves as a pivotal element in the poxvirus life cycle. Replication generates progeny genomes and initiates the transition to late gene expression. Unraveling the mechanism of poxvirus replication and identifying the panoply of enzymatic activities which it requires has been a focus of much recent research. The intent of this chapter is to move beyond previous reviews (McFadden and Dales 1982; Holowczak 1983) and focus on viral proteins whose participation in DNA replication is presumed on the basis of genetic or biochemical data. Implicit in this discussion was the choice of a broad definition of DNA replication, one which centers on DNA synthesis but also encompasses regulation of the topology of genomic DNA and its assembly into a nucleoprotein complex.

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  1. Departments of Cell Biology and Anatomy and Microbiology, Cornell University Medical College, New York, NY, 10021, USA

    P. Traktman

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  1. P. Traktman
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  1. Dept. of Immunology and Medical Microbiology, University of Florida, Gainesville, FL, 32610, USA

    Richard W. Moyer Ph.D.  & Peter C. Turner Ph.D.  & 

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© 1990 Springer-Verlag Berlin · Heidelberg

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Traktman, P. (1990). The Enzymology of Poxvirus DNA Replication. In: Moyer, R.W., Turner, P.C. (eds) Poxviruses. Current Topics in Microbiology and Immunology, vol 163. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75605-4_4

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  • DOI: https://doi.org/10.1007/978-3-642-75605-4_4

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