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Suppression of Host Resistance by Antigens of Cryptococcus Neoformans

  • Conference paper
Fungal Cell Wall and Immune Response

Part of the book series: NATO ASI Series ((ASIH,volume 53))

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Abstract

Normal immune fonction is a critical factor in resistance to the opportunistic yeast Cryptococcus neoformans. Disseminated cryptococcosis is most commonly associated with underlying illness which predisposes to disease. Patients with neoplastic disease, particularly chronic lymphatic leukemia, Hodgkin’s disease, chronic myelogenous leukemia and multiple myeloma, are at particular risk. Other risk factors include collagen diseases, sarcoidiosis, and immunosuppression associated with organ transplantation. More recently, the Acquired Immunodeficiency Disease Syndrome (AIDS) has emerged as the most important predisposing condition for development of disseminated cryptococcosis. Patients with AIDS have a number of immunological defects; the specific deficiency that accounts for the high incidence of cryptococcosis in AIDS patient is not known. An area of current interest is the extent to which the yeast is able to modulate the host resistance. the effects of the yeast on host resistance may be a contributing factor to the progression of disease in immunocompromised individuals.

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Authors and Affiliations

  1. University of Nevada, Reno, Nevada, USA

    T. R. Kozel

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  1. T. R. Kozel
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Editors and Affiliations

  1. Institut Pasteur, Unité de Mycologie, 25, rue du Dr. Roux, 75724, Paris Cedex 15, France

    J. P. Latgé

  2. Dept. of Entomology and Nematology, University of Florida, 32611-0711, Gainesville, FL, USA

    D. Boucias

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© 1991 Springer-Verlag Berlin Heidelberg

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Kozel, T.R. (1991). Suppression of Host Resistance by Antigens of Cryptococcus Neoformans . In: Latgé, J.P., Boucias, D. (eds) Fungal Cell Wall and Immune Response. NATO ASI Series, vol 53. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76074-7_30

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  • DOI: https://doi.org/10.1007/978-3-642-76074-7_30

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76076-1

  • Online ISBN: 978-3-642-76074-7

  • eBook Packages: Springer Book Archive

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