Skip to main content
SpringerLink
Log in

Nutritional Myopathy: Selenium-Vitamin E Deficiency, Rat and Mouse

  • Chapter
Cardiovascular and Musculoskeletal Systems

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

  • 189 Accesses

Abstract

In affected young rats and mice, generalized involvement of the skeletal musculature may be seen. The muscles may have scattered white longitudinal streaks or show diffuse involvement with a dry, gritty white to yellow-gray appearance (Mason 1973) (Fig. 161). The lesions are bilaterally symmetric. In adult rats with long-term vitamin E deficiency, the muscles show marked atrophy and appear yellowish-brown with pale streaks (Telford 1971).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Burek JD (1978) Pathology of aging rats. CRC, Boca Raton, Fla, pp 153–160

    Google Scholar 

  • Chen XS (1982) Selenium and Keshan disease. Ann NY Acad Sci 393: 224–225

    Article  Google Scholar 

  • Coulton GR, Morgan JE, Partridge TA, Sloper JC (1988) The mdx mouse skeletal muscle myopathy. I. A histological, morphometric and biochemical investigation. Neuropathol Appl Neurobiol 14: 53–70

    Article  PubMed  CAS  Google Scholar 

  • Dische MR, Porro RS (1970) The cardiac lesions in Bassen-Kornzweig syndrome. Report of a case with autopsy findings. Am J Med 49: 568–571

    Article  PubMed  CAS  Google Scholar 

  • Freeman BA, Crapo JD (1982) Free radicals and tissue injury. Lab Invest 47: 412–426

    PubMed  CAS  Google Scholar 

  • Ge K, Xue A, Bai J, Wang S (1983) Keshan disease: an endemic cardiomyopathy in China. Virchows Arch [Pathol Anat] 401: 1–15

    Article  CAS  Google Scholar 

  • Gu B (1983) Pathology of Keshan disease. A comprehensive review. Chin Med J 96: 251–261

    PubMed  CAS  Google Scholar 

  • Hadlow WJ (1962) Diseases of skeletal muscle. In: Innes JRM, Saunders LZ (eds) Comparative neuropathology. Academic, New York, pp 147–243

    Google Scholar 

  • Hadlow WJ (1973) Myopathies of animals. In: Pearson CM (ed) The striated muscle. Int Acad Pathol Monogr 12: 364–409

    Google Scholar 

  • Harman PJ, Tassoni JB, Curtis RL, Hollinshead MB (1963) Muscular dystrophy in the mouse. In: Bourne GH, Golarz MN (eds) Muscular dystrophy in man and animals. Hafner, Riverside, pp 407–456

    Google Scholar 

  • Hide DW, Martlew R (1977) Cystic fibrosis and myocardial fibrosis ( Letter ). Arch Dis Child 52: 163

    Article  PubMed  CAS  Google Scholar 

  • Hoekstra WG (1975) Biochemical function of selenium and its relation to vitamin E. Fed Proc 34: 2083–2089

    CAS  Google Scholar 

  • Howes EL Jr, Price HM, Blumberg JM (1964) The effects of a diet producing lipochrome pigment (ceroid) on the ultrastructure of skeletal muscle in the rat. Am J Pathol 45: 599–631

    PubMed  Google Scholar 

  • Hulland TJ (1985) Muscles and tendons. In: Jubb KFV, Kennedy PC, Palmer N (eds) Pathology of domestic animals, vol 1, 3rd edn. Academic, New York, pp 139– 199

    Google Scholar 

  • Kakulas BA (1982) Skeletal muscle. In: Riddell RH (ed) Pathology of drug induced and toxic diseases. Churchill Livingstone, New York, pp 49–69

    Google Scholar 

  • Lannek N, Lindberg P (1975) Vitamin E and selenium deficiences ( VESD) of domestic animals. Adv Vet Sci Comp Med 19: 127–164

    PubMed  CAS  Google Scholar 

  • Li GS, Wang F, Kang D, Li C (1985) Keshan disease: an endemic cardiomyopathy in China. Hum Pathol 16: 602–609

    Article  PubMed  CAS  Google Scholar 

  • Lin CT, Chen LH (1982) Ultrastructural and lysosomal enzyme studies of skeletal muscle and myocardium in rats with long-term vitamin E deficiency. Pathology 14: 375–382

    CAS  Google Scholar 

  • Mason KE (1973) Effects of nutritional deficiency on muscle. In: Bourne GH (ed) The structure and function of muscle, vol 4, 2nd edn. Academic, New York, pp 155–206

    Google Scholar 

  • Mason KE, Horwitt MK (1972) Effects of deficiency in animals. In: Sebrell WH Jr, Harris RS (eds) The vitamins. Chemistry, physiology, pathology, methods, vol 5,2nd edn. Academic, New York, pp 272–292

    Google Scholar 

  • Nelson JS (1980) Pathology of vitamin E deficiency. In: Machlin LJ (ed) Vitamin E. A comprehensive treatise. Dekker, New York, pp 397–428

    Google Scholar 

  • Nezelof C, LeSec G (1979) Multifocal myocardial necrosis and fibrosis in pancreatic diseases of children. Pediatrics 63: 361–368

    PubMed  CAS  Google Scholar 

  • Pappenheimer AM (1942) Muscular dystrophy in mice on a vitamin E-deficient diet. Am J Pathol 18: 169–181

    PubMed  CAS  Google Scholar 

  • Rumery RE, Hampton JC (1959) Microscopic and sub- microscopic observations on skeletal muscle from vitamin E-deficient rats. Anat Rec 133: 1–11

    Article  CAS  Google Scholar 

  • Saito K, Matsumoto S, Yokoyama T, Okaniwa M, Kamoshta S (1982) Pathology of chronic vitamin E deficiency in fatal familial intrahepatic cholestasis ( Byler’s disease ). Virchows Arch [Pathol Anat] 396: 319–330

    Article  CAS  Google Scholar 

  • Sokol RJ, Heubi JE, Iannaccone ST, Bove KE, Balistreri WF (1984) Vitamin E deficiency with normal serum vitamin E concentrations in children with chronic cholestasis. N Engl J Med 310: 1209–1212

    Article  PubMed  CAS  Google Scholar 

  • Sung JH, Park SH, Mastri AR, Warwick WJ (1980) Axonal dystrophy in the gracile nucleus in congenital biliary atresia and cystic fibrosis (mucoviscidosis): beneficial effect of vitamin E therapy. J Neuropathol Exp Neurol 39: 584–597

    Article  PubMed  CAS  Google Scholar 

  • Telford IR (1971) Experimental muscular dystrophies in animals: a comparative study. Thomas, Springfield, pp 3–243

    Google Scholar 

  • Tobin CE (1950) Effects of vitamin E deficiency and cod liver oil on myopathy in mice. Arch Pathol 50: 385– 392

    CAS  Google Scholar 

  • Tomasi LG (1979) Reversibility of human myopathy caused by vitamin E deficiency. Neurology (Minneap) 29: 1182–1186

    CAS  Google Scholar 

  • Van Vleet JF, Ferrans VJ (1986) Comparative pathology of selenium and vitamin E deficiency and excess. Curr Top Nutr Dis 15: 359–396

    Google Scholar 

  • West WT, Murphy ED (1960) Histopathology of hered-itary, progressive muscular dystrophy in inbred strain 129 mice. Anat Rec 137: 279–295

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. John F. Van Vleet
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Victor J. Ferrans
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Emeritus, Harvard Medical School, ILSI Research Foundation, 1126 Sixteenth Street, N.W., 20036, Washington D.C., USA

    Thomas Carlyle Jones D.V.M., D.Sc. (Professor of Comparative Pathology) (Professor of Comparative Pathology)

  2. Medizinische Hochschule Honnover, Institut für Experimentelle Pathologie, Konstanty-Gutschow-Strasse 8, W-3000, Hannover 61, Federal Republic of Germany

    Ulrich Mohr M.D. (Professor of Experimental Pathology) (Professor of Experimental Pathology)

  3. New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, 01772, Southborough, MA, USA

    Ronald Duncan Hunt D.V.M. (Professor of Comparative Pathology) (Professor of Comparative Pathology)

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Van Vleet, J.F., Ferrans, V.J. (1991). Nutritional Myopathy: Selenium-Vitamin E Deficiency, Rat and Mouse. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Cardiovascular and Musculoskeletal Systems. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76533-9_21

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-76533-9_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76535-3

  • Online ISBN: 978-3-642-76533-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation