Abstract
Intimai neovascularization, which represents the newly formed vasa vasorum, has been recognized in atherosclerotic plaques of human coronary arteries for many years (Winternitz et al. 1938; Barger et al. 1984; Kamat et al. 1987). Nevertheless, there are still several unresolved questions regarding the origin and pathogenesis of these newly formed blood vessels as well as their pathophysiologic significance in the progression and/or regression of atherosclerosis, and especially the development of its sequelae such as thrombi and intimal hemorrhage. It is well known that neovascularization is a ubiquitous and vital response in various physiologic and pathologic conditions such as embryonic development, the inflammatory-repair process, and the growth of solid cancer (Folkman 1990).
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Sueishi, K., Kumamoto, M., Sakuda, H., Tanaka, K. (1993). Angiogenic Processes in the Pathogenesis of Human Coronary Atherosclerosis. In: Roessner, A., Vollmer, E. (eds) Recent Progress in Atherosclerosis Research. Current Topics in Pathology, vol 87. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76849-1_2
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DOI: https://doi.org/10.1007/978-3-642-76849-1_2
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