Abstract
The vasculitides are important, both because they are recognized with increasing frequency and because they are potentially treatable causes of neurologic disease. Experimental systems of vascular inflammation have expanded our knowledge of the mechanisms associated with inflammation of the blood vessels. The challenge for the clinician and scientist is to recognize vasculitis, discover any identifiable causes, determine the mechanisms of disease, and devise a treatment that minimizes tissue injury without disabling the body’s normal immune function.
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References
Bishop DK, Jutila MA, Sedmak DD, Beattie MS, Orosz CG (1989) Lymphocyte entry into inflammatory tissues in vivo. Qualitative differences of high endothelial venule-like vessels in sponge matrix allografts vs isografts. J Immunol 142:4219–4224
Cochrane CG, Koffler D (1973) Immune complex disease in experimental animals and man. Adv Immunol 16:185–264
Dustin ML, Springer T (1988) Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells. J Cell Biol 107:321–331
Grau GE, Piguet P, Vassalli P, Lambert P (1989) Involvement of tumour necrosis factor and other cytokines in immune-mediated vascular pathology. Int Arch Allergy Appl Immunol 88:34–39
Guinan EC, Smith BR, Doukas JT, Miller RA, Pober JS (1989) Vascular endothelial cells enhance T cell responses by markedly augmenting IL-2 concentrations. Cell Immunol 118:166–177
Hart MN, Tassell SK, Sadewasser KL, Schelper RL, Moore SA (1985) Autoimmune vasculitis resulting from in vitro immunization of lymphocytes to smooth muscle. Am J Pathol 119:448–455
Henson PM, Johnston Jr RB (1987) Tissue injury in inflammation. Oxidants, proteinases, and cationic proteins. J Clin Invest 79:669–674
Henson PM (1971) Interaction of cells with immune complexes: adherence, release of constituents, and tissue injury. J Exp Med 134:114S-135S
Hickey WF, Kimura H (1988) Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science 23:290–292
Hughes JT, Brownell B (1966) Granulomatous giant-celled angiitis of the central nervous system. Neurology 16:293–298
Jirik FR, Podor TJ, Hirano T et al. (1989) Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells. J Immunol 142:144–147
Kimani G, Tonnesen MG, Henson PM (1988) Stimulation of eosinophil adherence to human vascular endothelial cells in vitro by platelet-activated factor. J Neuroimmunol 140:3161–3166
Leung DYM, Geha RS, Newburger JW et al. (1986) Two monokines, interleukin 1 and tumor necrosis factor, render cultured vascular endothelial cells susceptible to lysis by antibodies circulating during kawasaki syndrome. J Exp Med 164:1958–1972
McIntosh RW, Koss MM (1974) The choroid plexus: immunologic injury and disease. Ann Int Med 81:111–113
Moore PM, Cupps TR (1983) Neurological complications of vasculitis. Ann Neurol 14:155–167
Moore PM (1989) Immune mechanisms in the primary and secondary vasculitides. J Neurol Sci 93:129–145
Moyer CF, Strandberg JD, Reinisch CL (1987) Systemic mononuclear-cell vasculitis in MRL/Mp-lpr/lpr mice. A histologic and immunocytochemical analysis. Am J Pathol 127:229–242
Porter DD, Larsen AE, Porter HG (1973) The Pathogenesis of Aleutian mink disease III: Immune Complex Arteritis. Am J Pathol 71:331–344
Stevens SK, Weissman IL, Butcher EC (1982) Differences in the migration of B and T lymphocytes: organ-selective localization in vivo and the role of lymphocyte-endothelial cell recognition. J Immunol 128:844–851
Van Der Woude FJ, Rasmussen N, Lobatto S et al. (1985) Autoantibodies against neutrophils and monocytes: tool for diagnosis and marker of disease activity in Wegener’s granulomatosis. Lancet ii:425–429
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© 1993 Springer-Verlag Berlin Heidelberg
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Moore, P.M. (1993). Mechanisms of the Immune-Mediated Vasculitides. In: Berlit, P., Moore, P.M. (eds) Vasculitis, Rheumatic Disease and the Nervous System. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77122-4_1
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DOI: https://doi.org/10.1007/978-3-642-77122-4_1
Publisher Name: Springer, Berlin, Heidelberg
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