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Pathogenesis and Immunology in Shigellosis: Applications for Vaccine Development

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Pathogenesis of Shigellosis

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 180))

Abstract

Although the immunological basis of protection from shigellosis is poorly understood, it is likely that secretory immunoglobulin A (IgA) on mucosal surfaces and mucosal lymphocytes in the intestine play important roles in this process. Therefore, a summary of the possible protective roles of lymphocytes and immunoglobulin will provide a context for the subsequent discussion of Shigella vaccine development.

The views of the authors do not purport to reflect the position of the Department of the Army or the Department of Defence (paragraph 4–3 AR 360–5)

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Author information

Authors and Affiliations

  1. Department of Enteric Infections, Walter Reed Army Institute of Research, 20307-5100, Washington,DC, USA

    T. L. Hale

  2. Ward Medical Laboratories, 48105, Ann Arbor, MI, USA

    D. F. Keren

Authors
  1. T. L. Hale
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  2. D. F. Keren
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Editors and Affiliations

  1. Unité de Pathogénie Microbienne Moleculaire, Institut Pasteur, 28, Rue du Dr. Roux, 75724, Paris Cedex 15, France

    P. J. Sansonetti M.D

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© 1992 Springer-Verlag Berlin Heidelberg

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Hale, T.L., Keren, D.F. (1992). Pathogenesis and Immunology in Shigellosis: Applications for Vaccine Development. In: Sansonetti, P.J. (eds) Pathogenesis of Shigellosis. Current Topics in Microbiology and Immunology, vol 180. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77238-2_6

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  • DOI: https://doi.org/10.1007/978-3-642-77238-2_6

  • Publisher Name: Springer, Berlin, Heidelberg

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  • Online ISBN: 978-3-642-77238-2

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