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MHC Control of Growth and Metastatic Properties of Tumor Cells

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The HLA System in Clinical Transplantation

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Abstract

The question whether cancer cells possess specific cell surface antigens which do not appear on normal cells of the human organism has intrigued scholars since the early days of cancer research. The obvious aim was to identify cancer-specific antigens in order to use them as vaccines for immunotherapy of cancer. Yet, all early attempts to demonstrate antigens specific to human tumor cells failed, since antigens detected on tumor cells were found to exist also on normal cells. The first demonstration that cancer cells may possess specific antigens came from experiments in which tumors induced in mice by a chemical carcinogen, the polycyclic hydrocarbon methylcholanthrene, were tested for antigenic specificity. When the primary tumors were transplanted to syngeneic animals, they grew; however, if following their initial growth the tumors were surgically removed and the animals were transplanted with a second graft of the same tumor, this second transplant was rejected (Foley 1953; Prehn and Main 1957). Thus, the first graft elicited transplantation immunity which was strong enough to prevent the growth of a second graft of the same tumor. Since grafts of normal tissues from the tumor-bearing mice did not elicit an immune response against a subsequent tumor graft, the rejection of the secondary tumor transplant was attributed to an immune response elicited by tumor-specific antigens (Prehn and Main 1957).

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Authors
  1. M. Feldman
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  2. L. Eisenbach
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Editors and Affiliations

  1. Department Group for Laboratory Medicine, University of Oslo Rikshospitalet, Pilestredet 32, 0027, Oslo, Norway

    Bjarte G. Solheim

  2. Department of Microbiology and Immunology, New York Medical College, 10595, Valhalla, NY, USA

    Soldano Ferrone

  3. Department for Clinical Immunology, Huddinge sjukhus, 141 86, Huddinge, Sweden

    Erna Möller

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© 1993 Springer-Verlag Berlin Heidelberg

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Feldman, M., Eisenbach, L. (1993). MHC Control of Growth and Metastatic Properties of Tumor Cells. In: Solheim, B.G., Ferrone, S., Möller, E. (eds) The HLA System in Clinical Transplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77506-2_13

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  • DOI: https://doi.org/10.1007/978-3-642-77506-2_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77508-6

  • Online ISBN: 978-3-642-77506-2

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