Abstract
Polyesters derived from aliphatic hydroxy carbonic acids are a well known class of synthetic bioresorbable polymers. The biodegradation normally proceeds by random bulk hydrolysis of ester bonds without a significant contribution of enzymatic attack. Enzymatic surface erosion is restricted to rubbery polylactones with low elastic moduli with only one example reported in the literature 2. As rubbery polylactones, rubbery poly(ethylene carbonate) 3 and poly(trimethylene carbonate) 4 are reported to degrade in vivo by enzymatic action.
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References
A. Schindler, C. G. Pitt, Transact. Soc. Biomat. 8, 217, 1985
C. G. Pitt, R. W. Hendren, A. Schindler, J. Controlled Rel. 1, 3–14, 1984
T. Kawaguchi, M. Nakano, K. Juni, S. Inoue, Y. Yoshida, Chem. Pharm. Bull. 31, 1400–1403, 1983
K. J. Zhu, R. W. Hendren, K. Jensen, C. G. Pitt, Macromolecules, 24, 1736–1740, 1991
F. G. Hutchinson, B. J. A. Furr, J. Controlled Rel. 13, 279–294, 1990
B. Buchholz, Transact. Soc. Biomat. 14, 221, 1991
C. G. Pitt, Z. W. Gu, J. Controlled Rel. 4, 283–292, 1987
W. Fischer, H. J. Sterzel, G. Wegner, Kolloid-Z. u. Z. Polymere, 251, 980–990, 1973
J. Rak, J. L. Ford, C. Rostron, V. Walters, Pharm. Acta Helv. 60, 162–169, 1985
N. S. Mason, C. S. Miles, R. E. Sparks, Coat. Plast. Chem. 42, 436–440, 1980
K. Makino, M. Arakawa, T. Kondo, Chem. Pharm. Bull. 33, 1195–1201, 1984
A. M. Reed, D. K. Gilding, Polymer, 22, 494–498, 1981
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© 1992 Springer-Verlag Berlin Heidelberg
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Buchholz, B. (1992). Accelerated Degradation Test on Resorbable Polymers. In: Planck, H., Dauner, M., Renardy, M. (eds) Degradation Phenomena on Polymeric Biomaterials. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77563-5_6
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DOI: https://doi.org/10.1007/978-3-642-77563-5_6
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