Abstract
In Burkitt’s lymphoma, c-myc is most frequently translocated from chromosome 8 (q34) to the immunoglobulin heavy chain region on chromosome 14 (q32) where its expression is deregulated by virtue of its juxtaposition to enhancer sequences [1]. Because of the frequent location of the chromosomal breakpoint in DNA regions which are normally involved in the physiological recombination of immunoglobulin genes, it has been hypothesized that the immunoglobulin recombinases normally responsible for the creation of a functional immunoglobulin gene may mediate these translocations [2]. It has also been proposed that switch recombinases could mediate a proportion of translocations — presumably, those, or a fraction of those in which the breakpoint is within a switch region [3].
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© 1992 Springer-Verlag Berlin Heidelberg
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Bhatia, K., Gutierrez, M., Magrath, I.T. (1992). Burkitt’s Lymphoma Cells Frequently Carry Monoallelic DJ Rearrangements. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1992. Current Topics in Microbiology and Immunology, vol 182. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77633-5_40
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DOI: https://doi.org/10.1007/978-3-642-77633-5_40
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