Abstract
B lineage cells in the bone marrow can be recognized by the expression of the high molecular weight form of the common leukocyte antigen CD45, known as B220. We showed recently [1, 2] that a small portion of these cells in bone marrow co-express leukosialin, CD43 [3, 4], and that many of these cells possessed D-J, but not V-D-J rearrangements. Further analysis with other markers revealed that this D-J rearranging population was contained in the fraction of B220+CD43+ cells that also expressed intermediate levels of the heat stable antigen, HSA. We showed that in short term culture, many of these cells would progress to the Pre-B and B cell stages. We have termed cells with this phenotype “Pro-B”. These Pro B cells can be detected both in bone marrow and fetal, known sources of B lymphopoiesis (Figure 1).
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© 1992 Springer-Verlag Berlin Heidelberg
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Hardy, R.R., Shinton, S.A., Hayakawa, K. (1992). Repopulation of SCID Mice with Fetal-Derived B-Lineage Cells. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1992. Current Topics in Microbiology and Immunology, vol 182. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77633-5_9
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DOI: https://doi.org/10.1007/978-3-642-77633-5_9
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