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Clinical Features and Management of Gynecologic Yolk Sac Tumors

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The Human Yolk Sac and Yolk Sac Tumors

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Abstract

Malignant ovarian germ cell tumors account for less than 5% of all ovarian cancers, an incidence approximately one-tenth that of testicular cancer. Yolk sac tumors represent the second most common histologic type within this category. Before the advent of combination chemotherapy in the late 1960s, the prognosis of patients with this neoplasm was uniformly poor. Since then, we have steadily progressed toward cure rates approaching 100%.

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References

  • Abelev GI (1974) Alpha-fetoprotein as a marker of embryo-specific differentiation in normal and tumor tissue. Transplant Rev 20:3–37.

    PubMed  CAS  Google Scholar 

  • Abelev GI, Perova SD, Khramkova NI, Postnikova A, Win IS (1963) Production of embryonal alpha-globulin by transplantable mouse hepatomas. Transplant Bull 1:174–180.

    CAS  Google Scholar 

  • Allyn DL, Silverberg SG, Salzberg AM (1971) Endodermal sinus tumor of the vagina: report of a case with 7-year survival and literature review of so-called “mesonephromas.” Cancer 27:1231–1238.

    Article  PubMed  CAS  Google Scholar 

  • Andersen WA, Sabio H, Durso N, Mills SE, Levien M, Underwood PB (1985) Endodermal sinus tumor of the vagina. The role of primary chemotherapy. Cancer 56:1025–1027.

    Article  PubMed  CAS  Google Scholar 

  • Bakri YN, Given FT (1984) Normal pregnancy and delivery following conservative surgery and chemotherapy for ovarian endodermal sinus tumor. Gynecol Oncol 19:222–225.

    Article  PubMed  CAS  Google Scholar 

  • Ballas M (1972) Yolk sac carcinoma of ovary with alpha fetoprotein in the serum and ascitic fluid demonstrated by immunoosmophoresis. Am J Clin Pathol 57:511–516.

    PubMed  CAS  Google Scholar 

  • Beller FK, Nienhaus H, Schmundt-v. Gizycki B, Schellong G, Bunte H, Schmandt W (1979) Endodermal germ cell carcinoma (endodermal sinus tumor of the vagina in infant girls. J Cancer Res Clin Oncol 94:295–306.

    Article  PubMed  CAS  Google Scholar 

  • Bergstrand CG, Czar BB (1956) Demonstration of a new protein fraction in serum from human fetus. Scand J Lab Invest 8:174–178.

    Article  CAS  Google Scholar 

  • Carlson RW, Sikic BI, Trubow MM Turbow, Ballon SC (1983) Combination cisplatin, vinblastine, and bleomycin chemotherapy (PVB) for malignant germ-cell tumors of the ovary. J Clin Oncol 1:645–651.

    PubMed  CAS  Google Scholar 

  • Clement PB, Young RH, Scully RE (1988) Extraovarian pelvic yolk sac tumors. Cancer 62:620–626.

    Article  PubMed  CAS  Google Scholar 

  • Collins HS, Burke TW, Heller PB, Olson TA, Woodward JE, Park RC (1989) Endodermal sinus tumor of the infant vagina treated exclusively by chemotherapy. Obstet Gynecol 73:507–509.

    PubMed  CAS  Google Scholar 

  • Copeland LJ, Sneige N, Ordonez NG, Hancock KC, Gershenson DM, Saul PB, Kavanagh JJ (1985) Endodermal sinus tumor of the vagina and cervix. Cancer 55:2558–2565.

    Article  PubMed  CAS  Google Scholar 

  • Creasman WT, Fetter BF, Hammond CB, Parker RT (1979) Germ cell malignancies of the ovary. Obstet Gynecol 53:226–230.

    PubMed  CAS  Google Scholar 

  • Curtin JP, Adcock LL (1986) Pregnancy following treatment of endodermal sinus tumor of the ovary with combination chemotherapy including cis-platinum. Gynecol Oncol 24:268–270.

    Article  PubMed  CAS  Google Scholar 

  • Davis TE, Loprinzi CL, Buchler DA (1984) Combination chemotherapy with cisplatin, vinblastine, and bleomycin for endodermal sinus tumor of the ovary. Gynecol Oncol 19:46–52.

    Article  PubMed  CAS  Google Scholar 

  • Dewhurst J, Ferreira HP (1981) An endodermal sinus tumour of the vagina in an infant with seven year survival. Br J Obstet Gynaecol 88:859–862.

    Article  PubMed  CAS  Google Scholar 

  • Einhorn LH, Donohue J (1977) Cis-diaminedichloroplatinum, vinblastine, and bleomycin combination chemotherapy in disseminated testicular cancer. Ann Intern Med 87:293–298.

    PubMed  CAS  Google Scholar 

  • Flamant F, Gerbaulet A (1981) Traitaient conservateur des tumeurs vulvo vaginales malignes de l’enfant par une approche multidisciplinaire (a l’exclusion des adeno-carcinomas a cellules claires). Bull Cancer (Paris) 68:154–157.

    CAS  Google Scholar 

  • Forney JP (1978) Pregnancy following removal and chemotherapy of ovarian endodermal sinus tumor. Obstet Gynecol 52:360–364.

    PubMed  CAS  Google Scholar 

  • Forney JP, DiSaia PH, Morrow CP (1975) Endodermal sinus tumor. A report of two sustained remissions treated postoperatively with a combination of actinomycin D, 5-fluorouracil, and cyclophosphamide. Obstet Gynecol 45:186–189.

    PubMed  CAS  Google Scholar 

  • Gallion H, Van Nagell JR, Powell DF, Donaldson ES, Hanson M (1979) Therapy of endodermal sinus tumor of the ovary. Am J Obstet Gynecol 135:447–451.

    PubMed  CAS  Google Scholar 

  • Gershenson DM (1988) Menstrual and reproductive function after treatment with combination chemotherapy for malignant ovarian germ cell tumors. J Clin Oncol 6:270–275.

    PubMed  CAS  Google Scholar 

  • Gershenson DM, Del Junco G, Herson J, Rutledge FN (1983) Endodermal sinus tumor of the ovary: the M.D. Anderson experience. Obstet Gynecol 61:194–202.

    PubMed  CAS  Google Scholar 

  • Gershenson DM, Copeland LJ, Kavanagh JJ et al. (1985) Treatment of malignant nondysgerminomatous germ cell tumors of the ovary with vincristine, actinomycin D, and cyclophosphamide. Cancer 56:2756–2761.

    Article  PubMed  CAS  Google Scholar 

  • Gershenson DM, Kavanagh JJ, Copeland LJ et al. (1986a) Treatment of malignant nondysgerminomatous germ cell tumors of the ovary with vinblastine, bleomycin, and cisplatin. Cancer 57:1731–1737.

    Article  PubMed  CAS  Google Scholar 

  • Gershenson DM, Copeland LJ, Del Junco G, Edwards CL, Wharton JT, Rutledge FN (1986b) Second-look laparotomy in the management of malignant germ cell tumors of the ovary. Obstet Gynecol 67:789–793.

    Article  PubMed  CAS  Google Scholar 

  • Gershenson DM, Morris M, Cangir A, Kavanagh JJ, Stringer CA, Edwards C, Silva E, Wharton JT (1990) Treatment of malignant germ cell tumors of the ovary with bleomycin, etoposide, and cisplatin. J Clin Oncol 8:715–720.

    PubMed  CAS  Google Scholar 

  • Gitlin D, Perricelli A, Gitlin GM (1972) Synthesis of alpha-fetoprotein by liver, yolk sac, and gastrointestinal tract of the human conceptus. Cancer Res 32:979–982.

    PubMed  CAS  Google Scholar 

  • Itoh T, Shirai T, Naka A, Matsumoto S (1974) Yolk tumor and alpha-fetoprotein. Clinico-pathological study of four cases. Gann 65:215–226.

    Google Scholar 

  • Jacobs AJ, Harris M, Deppe G et al. (1982) Treatment of recurrent germ cell tumors with cisplatin, vinblastine, and bleomycin. Obstet Gynecol 59:129–132.

    PubMed  CAS  Google Scholar 

  • Jimerson GK, Woodruff JD (1977) Ovarian extraembryonal teratoma. Am J Obstet Gynecol 127:73–79.

    PubMed  CAS  Google Scholar 

  • Julian CG, Barrett JM, Richardson RL et al. (1979) Bleomycin, vinblastine, and cis-platinum in the treatment of advanced endodermal sinus tumor. Obstet Gynecol 56:396.

    Google Scholar 

  • Karlen JR, Kastelic JE (1980) Endodermal sinus tumor of the ovary: an improving prognosis. Gynecol Oncol 10:206–216.

    Article  PubMed  CAS  Google Scholar 

  • Kim DS, Park M (1989) Maternal and fetal survival following surgery and chemotherapy of endodermal sinus tumor of the ovary during pregnancy: a case report. Obstet Gynecol 73:503–507.

    PubMed  CAS  Google Scholar 

  • Krishnamurthy SC, Sampat MB (1981) Endodermal sinus (yolk sac) tumor of the vulva in a pregnant female. Gynecol Oncol 11:379–382.

    Article  PubMed  CAS  Google Scholar 

  • Kurman RJ, Norris HJ (1976) Endodermal sinus tumor of the ovary. A clinical and pathologic analysis of 71 cases. Cancer 38:2404–2419.

    Article  PubMed  CAS  Google Scholar 

  • Lokey JL, Baker JJ, Prince NA et al. (1981) Cisplatin, vinblastine, and bleomycin for endodermal sinus tumor of the ovary. Ann Intern Med 94:56–57.

    PubMed  CAS  Google Scholar 

  • Malone JM, Gershenson DM, Creasy R, Kavanagh JJ, Silva EG, Stringer CA (1986) Endodermal sinus tumor of the ovary associated with pregnancy. Obstet Gynecol 68:86S–89S.

    PubMed  CAS  Google Scholar 

  • Metz SA, Day TG, Purseil SH (1989) Adjuvant chemotherapy in a pregnant patient with endodermal sinus tumor of the ovary. Gynecol Obstet 32:371–374.

    CAS  Google Scholar 

  • Micha JP, Kucera PR, Berman ML, Romansky S, Flamm M, Reynolds J, DiSaia PJ (1985) Malignant ovarian germ cell tumors: a review of thirty-six cases. Am J Obstet Gynecol 152:842–846.

    PubMed  CAS  Google Scholar 

  • Newlands ES, Bagshawe KC (1977) Epipodophyllin derivative (VP-16-213) in malignant teratomas and choriocarcinomas. Lancet 2:87.

    Article  PubMed  CAS  Google Scholar 

  • Norgaard-Pedersen B, Albrechtesen R, Teilum G (1975) Serum alpha-fetoprotein as a marker for endodermal sinus tumor (yolk sac tumor) of a vitelline component of teratocarcinoma. Acta Pathol Microbiol Immunol Scand [A] 83:573–589.

    CAS  Google Scholar 

  • Norris HG, Bagley GP, Taylor HB (1970) Carcinoma of the infant vagina: a distinctive tumor. Arch Pathol 90:473–479.

    PubMed  CAS  Google Scholar 

  • Ohta M, Sakakibara K, Mizuno K, Kano T, Matsuzawa K, Tomoda Y, Nakashima N, Ogawa (1988) Successful treatment of primary endodermal sinus tumor of the endometrium. Gynecol Oncol 31:357–364.

    Article  PubMed  CAS  Google Scholar 

  • Paulussen F, Maintz EJ, Groop A, Hensen SD (1971) Das mesonephrogene Karzinom in Kindesalter. Geburtshilfe Frauenheilkd 31:228–240.

    PubMed  CAS  Google Scholar 

  • Pektasides D, Rustin GJS, Newlands ES, Begent RHJ, Bagshawe KD (1987) Fertility after chemotherapy for ovarian germ cell tumours. Br J Obstet Gynaecol 94:477–479.

    Article  PubMed  CAS  Google Scholar 

  • Petrucha RA, Ruffolo E, Messina AM, Bouis PJ, Praphat H (1980) Endodermal sinus tumor: report of a case associated with pregnancy. Obstet Gynecol [Suppl] 55:90–94.

    Google Scholar 

  • Pileri S, Martinelli G, Serra L, Bazzocchi F (1980) Endodermal sinus tumor arising in the endometrium. Obstet Gynecol 56:391–396.

    PubMed  CAS  Google Scholar 

  • Rezaizadeh MM, Woodruff JD (1978) Endodermal sinus tumor of the vagina. Gynecol Oncol 6:459–463.

    Article  PubMed  CAS  Google Scholar 

  • Samuels ML, Johnson DE, Holoye PY (1975) Continuous intravenous bleomycin therapy with vinblastine in stage III testicular neoplasia. Cancer Chemother Rep 59:563–570.

    PubMed  CAS  Google Scholar 

  • Sawada M, Okudaira Y, Matsui Y, Nishiura H, Iwasaki T, Kasamatsu H (1985) Cisplatin, vinblastine, and bleomycin therapy of yolk sac (endodermal sinus) tumor of the ovary. Gynecol Oncol 20:162–169.

    Article  PubMed  CAS  Google Scholar 

  • Schwartz PE (1984) Combination chemotherapy in the management of ovarian germ cell malignancies. Obstet Gynecol 64:564–572.

    PubMed  CAS  Google Scholar 

  • Schwartz R, Chatwani AJ, Strimel W, Putong PB (1983) Endodermal sinus tumor in pregnancy: report of a case and review of literature. Gynecol Oncol 15:434–439.

    Article  PubMed  CAS  Google Scholar 

  • Sessa C, Bonazzi C, Landoni F, Pecorelli S, Sartori E, Mangioni C (1987) Cisplatin, vinblastine, and bleomycin combination chemotherapy in endodermal sinus tumor of the ovary. Obstet Gynecol 70:220–224.

    PubMed  CAS  Google Scholar 

  • Slayton RE, Park RC, Silverberg SG, Shingleton H, Creasman WT, Blessing JA (1985) Vincristine, dactinomycin, and cyclophosphamide in the treatment of malignant germ cell tumors of the ovary: a Gynecologic Oncology Group Study (A final report). Cancer 56:243–248.

    Article  PubMed  CAS  Google Scholar 

  • Smales E, Peckham MJ (1987) Chemotherapy of germ-cell ovarian tumours: first-line treatment with etoposide, bleomycin and cisplatin or carboplatin. Eur J Cancer Clin Oncol 23:469–474.

    Article  PubMed  CAS  Google Scholar 

  • Smith EB, Clarke-Pearson DL, Creasman WT (1984) A VP16-213-and cisplatin-containing regimen for treatment of refractory ovarian germ cell malignancies. Am J Obstet Gynecol 150:927–931.

    PubMed  CAS  Google Scholar 

  • Smith JP, Rutledge FN (1975) Advances in chemotherapy for gynecologic cancer. Cancer 36:669–674.

    Article  PubMed  CAS  Google Scholar 

  • Talerman A, Haije WG (1974) Alpha-fetoprotein and germ cell tumors: a possible role of yolk sac tumor in production of alpha-fetoprotein. Cancer 34:1722–1726.

    Article  PubMed  CAS  Google Scholar 

  • Tatarinov YS (1964) Detection of embryospecific alpha-globulin in the blood sera of patients with primary liver tumor. Vopr Med Khim 10:90–91.

    PubMed  CAS  Google Scholar 

  • Taylor MH, DePetrillo AD, Turner AR (1985) Vinblastine, bleomycin, and cisplatin in malignant germ cell tumors of the ovary. Cancer 56:1341–1349.

    Article  PubMed  CAS  Google Scholar 

  • Ungerleider RS, Donaldson SS, Warnke RA, Wilbur JR (1978) Endodermal sinus tumor: the Stanford experience and the first reported case arising in the vulva. Cancer 41:1627–1634.

    Article  PubMed  CAS  Google Scholar 

  • Vriesendrop R, Aalders JG, Sleijfer DT, Willemse PHB, Bouma J, Mulder NH (1984) Treatment of malignant germ cell tumors of the ovary with cisplatin, vinblastine, and bleomycin (PVB). Cancer Treat Rep 68:779–781.

    Google Scholar 

  • Weed JC, Roh RA, Mendenhall HW (1979) Recurrent endodermal sinus tumor during pregnancy. Obstet Gynecol 54:653–656.

    PubMed  CAS  Google Scholar 

  • Wilkinson EJ, Friedrich EG, Hosty TA (1973) Alpha-fetoprotein and endodermal sinus tumor of the ovary. Am J Obstet Gynecol 116:711–714.

    PubMed  CAS  Google Scholar 

  • Willemse PHB, Aalders JG, Bouma J, Mulder NH, Verschueren RCJ, de Vries EGE, Sleijfer D (1987) Long-term survival after vinblastine, bleomycin, and cisplatin treatment in patients with germ cell tumors of the ovary: an update. Gynecol Oncol 28:268–277.

    Article  PubMed  CAS  Google Scholar 

  • Williams SD, Birch R, Einhorn LH, Irwin L, Greco FA, Loehrer PJ (1987) Treatment of disseminated germ-cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide. N Engl J Med 316:1435–1440.

    Article  PubMed  CAS  Google Scholar 

  • Williams SD, Blessing JA, Moore DH, Homesley HD, Adcock L (1989) Cisplatin, vinblastine, and bleomycin in advanced and recurrent ovarian germ-cell tumors. Ann Intern Med 111:22–27.

    PubMed  CAS  Google Scholar 

  • Wiltshaw E, Stuart-Harris R, Barker GH et al. (1982) Chemotherapy of endodermal sinus tumour (yolk sac tumor) of the ovary: preliminary communication. J R Soc Med 75:888–892.

    PubMed  CAS  Google Scholar 

  • Wong LC, Ngan HYS, Ma HK (1989) Primary treatment with vincristine, dactinomycm, and cyclophosphamide in nondysgerminomatous germ cell tumor of the ovary. Gynecol Oncol 34:155–158.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. D. M. Gershenson
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Editors and Affiliations

  1. Head of Department, University Hospital, E-18012, Granada, Spain

    Francisco F. Nogales (Professor of Pathology) (Professor of Pathology)

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© 1993 Springer-Verlag Berlin Heidelberg

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Gershenson, D.M. (1993). Clinical Features and Management of Gynecologic Yolk Sac Tumors. In: Nogales, F.F. (eds) The Human Yolk Sac and Yolk Sac Tumors. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77852-0_14

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  • DOI: https://doi.org/10.1007/978-3-642-77852-0_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77854-4

  • Online ISBN: 978-3-642-77852-0

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