Abstract
Peptide and protein hormones and transmitters play a wide variety of extremely important regulatory roles in the body. A large number of these molecules have been isolated and shown to act as very potent messengers carrying specific signals between cells in the body. They frequently have valuable therapeutic properties. For some diseases the natural peptide may be used but often analogs of the peptides are used. An example of the first type of application is replacement therapy with insulin for diabetes or with growth hormone for pituitary deficiency. Where the natural peptide is not administered it may serve as a lead for products modified to improve biological specificity, to produce a receptor antagonist, or to optimize pharmacokinetic properties. Whether the peptide is administered as a natural or a modified product, understanding of the pharmacokinetics can be helpful in a variety of ways.
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McMartin, C. (1994). Peptide and Protein Drugs. In: Welling, P.G., Balant, L.P. (eds) Pharmacokinetics of Drugs. Handbook of Experimental Pharmacology, vol 110. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78680-8_13
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DOI: https://doi.org/10.1007/978-3-642-78680-8_13
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