Abstract
Compared to other disciplines involved in drug discovery and development, with the possible exception of biotechnology, pharmacokinetics is a relative newcomer. If one delves into the literature one can find early articles that relate to the subject matter. For example, in 1847 Buchanan related depth of narcosis to brain content and arterial concentrations of anesthetics, while in the same year, Snow (1847) commented on the need to regulate the strength of medicinal compounds. However, these were early days, and preceded the introduction of analytical technology and the intellectual maturation necessary for the study of pharmacokinetics in its present form.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Balant LP, Roseboom H, Gundert-Remy UM (1990) Pharmacokinetic criteria for drug research and development. Adv Drug Res 19: 6–139
Buchanan A (1847) Physiologic effects of the inhalation of ether. Lond Med Gaz 39: 715–717
De la Iglesia FA, Greaves P (1989) Role of toxicokinetics in drug safety evaluations. In: Yacobi A, Skelly JP, Batra VK (eds) Toxicokinetics and new drug development. Pergamon, New York, pp 21–32
Dost FH (1953) Die Blutspiegelkinetik der Konzentrationsabläufe in der Kreislaufflüssigkeit. Thieme, Leipzig
Goldstein A (1949) The interaction of drugs and plasma proteins. Pharmacol Rev 1: 102–165
Haggard HW (1924) The absorption, distribution and elimination of ethyl ether. I. The amount of ether absorbed in relation to the concentration inhaled and its fate in the body. J Biol Chem 59: 737–751
Lemberger L (1989) Pharmacokinetics and adverse reactions: an overview. In: Yacobi A, Skelly JP, Batra VK (eds) Toxicokinetics and new drug development. Pergamon, New York, pp 114–123
Nelson E (1961) Kinetics of drug absorption, distribution, metabolism, and excretion. J Pharm Sci 50: 181–192
Rowland E, Aarons L (eds) (1992) New strategies in drug development and clinical evaluation: the population approach. Conference, Manchester, UK, September 21–23, 1991. Office for Official Publications of the European Communities, Luxembourg
Snow J (1847) On the inhalation of the vapour of ether. Lond Med Gaz 39: 498–502
Teorell T (1937a) Kinetic of distribution of substances administered to the body. I. The extravascular modes of administration. Arch Int Pharmacodyn 57: 205–225
Teorell T (1937b) Kinetics of distribution of substances administered to the body. II. The intravascular modes of administration. Arch Int Pharmacodyn 57: 226–240
Toothaker RD, Welling PG (1980) The effect of food on drug bioavailability. Annu Rev Pharmacol Toxicol 20: 173–199
Wagner JG (1968) Pharmacokinetics. Annu Rev Pharmacol 8: 67–94
Welling PG (1977) Influence of food and diet on gastrointestinal drug absorption: a review. J Pharmacokinet Biopharm 5: 291–334
Widmark EMP (1932) Die theoretischen Grundlagen und die praktische Verwendbarkeit der gerichtlichmedizinischen Alkoholbestimmung. Urban and Schwarzenberg, Berlin
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Welling, P.G. (1994). Role of Pharmacokinetics in Drug Discovery and Development. In: Welling, P.G., Balant, L.P. (eds) Pharmacokinetics of Drugs. Handbook of Experimental Pharmacology, vol 110. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78680-8_1
Download citation
DOI: https://doi.org/10.1007/978-3-642-78680-8_1
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-78682-2
Online ISBN: 978-3-642-78680-8
eBook Packages: Springer Book Archive