Zusammenfassung
T-Lymphozyten sind als Regulator- und Effektorzellen der Immunantwort eine wichtige Zellpopulation des Darmimmunsystems. Die Induktion und Aufrechterhaltung der Schleimhautimmunität durch das sekretorische Immunglobulin A wird wesentlich durch T-Lymphozyten gesteuert [18]. Außerdem vermitteln die T-Zellen die Entwicklung von oraler Toleranz, d. h. es wird verhindert, daß die antigenen Bestandteile der Nahrung zu einer systemischen Immunantwort führen [4]. T-Lymphozyten befinden sich in der Darmschleimhaut einerseits diffus verteilt im Epithel und in der Lamina propria [3, 8] und andererseits im organisierten lymphatischen Gewebe, den Peyerschen-Platten [14]. Die T-Lymphozyten der Darmschleimhaut sind beim Menschen und anderen Spezies ausführlich charakterisiert worden, ihre Kinetik wurde aber bisher wenig berücksichtigt, d. h. es gibt wenig Informationen über ihre Migration und Proliferation.
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Rothkötter, HJ., Pabst, R. (1993). Immunantworten im Darm unter normalen Bedingungen — Suppression, Helfermechanismen und die Rolle von T-Zellen. In: Zeitz, M., Caspary, W.F., Bockemühl, J., Lux, G. (eds) Ökosystem Darm V. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78733-1_19
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