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Regulation of HIV-1 Gene Expression by the Transactivator Protein Tat

  • Chapter
Transacting Functions of Human Retroviruses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 193))

Abstract

The regulation of HIV-1 gene expression is an area of intense investigation. Like all retroviruses, HIV-1 integrates into cellular DNA, and its gene expression is dependent on host cell transcription factors and polymerases (Gaynor 1992). Cellular transcription factors are able to interact with distinct regulatory regions in the long terminal repeat to modulate gene expression (Gaynor 1992). In addition, viral-encoded proteins are critical to the control of HIV-1 gene expression. A number of important questions exist concerning the mechanisms which regulate HIV-1 gene expression. What cellular factors are responsible for increases in HIV-1 gene expression in response to T-lymphocyte activation? What are the mechanisms that repress HIV-1 gene expression in quiescent cells? How do HIV-1 transactivator proteins stimulate increases in gene expression? An understanding of these questions is critical to determining the interplay between viral and cellular factors which regulate HIV-1 gene expression.

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Authors and Affiliations

  1. Division of Molecular Virology, Departments of Medicine and Microbiology, University of Texas Southwestern Medical School, Dallas, TX, 75235, USA

    R. B. Gaynor

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  1. R. B. Gaynor
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Editors and Affiliations

  1. Division of Hematology/Oncology, 11-934 Factor, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA, 90024-1678, USA

    Irvin S. Y. Chen

  2. Department of Microbiology and Immunology Head of the Center of Neurovirology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA, 10107, USA

    Hilary Koprowski

  3. Department of Microbiology/Immunology Center for Neurovirology, Jefferson Medical College, Rm. 469 Jefferson Alumni Hall 1020 Locust Street, Philadelphia, PA, 19107-6799, USA

    Alagarsamy Srinivasan

  4. The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Peter K. Vogt

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© 1995 Springer-Verlag Berlin Heidelberg

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Gaynor, R.B. (1995). Regulation of HIV-1 Gene Expression by the Transactivator Protein Tat. In: Chen, I.S.Y., Koprowski, H., Srinivasan, A., Vogt, P.K. (eds) Transacting Functions of Human Retroviruses. Current Topics in Microbiology and Immunology, vol 193. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78929-8_3

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  • DOI: https://doi.org/10.1007/978-3-642-78929-8_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78931-1

  • Online ISBN: 978-3-642-78929-8

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