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The Polymorphonuclear Neutrophil: A Newly Recognized Participant in the Immune Response

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Immunology and Its Impact on Infections in Surgery

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Abstract

A large body of evidence exists to show that, following major injury or surgery, patients may become immunosuppressed and this may lead to increased susceptibility to life-threatening infections [1–4]. Recent research by numerous investigators has shown that the secretion of the proinflammatory cytokines IL-1, TNF, and IL-6 are markedly elevated in patients following major injury and that this may lead to some of the clinical effects seen in these patients, such as a process of systemic inflammation leading to multiple organ dysfunction (MOD) [5]. Clinical trials of agents which block endotoxin and TNF are currently underway in these patients. Most of this work has focussed on the monocyte/macrophage as the major participant in the proinflammatory cytokine cascade and as a modulator of the immune response of lymphocytes. The goal of this paper is to suggest that the other major phagocytic cell, the polymorphonuclear neutrophil (PMN), has that same potential.

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Authors
  1. M. L. Rodrick
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  1. Chirurgische Universitäts- und Poliklinik, Universität Würzburg, Josef-Schneider-Str. 2, 97080, Würzburg, Germany

    Rainer Engemann , Rene Holzheimer  & A. Thiede ,  & 

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© 1995 Springer-Verlag Berlin Heidelberg

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Rodrick, M.L. (1995). The Polymorphonuclear Neutrophil: A Newly Recognized Participant in the Immune Response. In: Engemann, R., Holzheimer, R., Thiede, A. (eds) Immunology and Its Impact on Infections in Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79079-9_20

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  • DOI: https://doi.org/10.1007/978-3-642-79079-9_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-58145-1

  • Online ISBN: 978-3-642-79079-9

  • eBook Packages: Springer Book Archive

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