Abstract
The in vitro bactericidal activity of an antibiotic is not always correlated with therapeutic efficacy. One of the numerous factors contributing to the discrepancy between activity against bacteria growing in vitro and in vivo is the growth rate. A characteristic response of bacteria to environmental changes such as growth in an infected focus is a reduction in the growth rate. Slowly growing bacteria generally survive better than those replicating quickly [1–4]; spore formation is an extreme example [1,5].
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Dalhoff, A., Matutat, S., Ullmann, U. (1994). Effect of Quinolones Against Slowly Growing Bacteria. In: Garrard, C. (eds) Ciprofloxacin i.v.. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79098-0_1
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DOI: https://doi.org/10.1007/978-3-642-79098-0_1
Publisher Name: Springer, Berlin, Heidelberg
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