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SPECT bei zerebrovaskulären Erkrankungen

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Single-Photon-Emissions-Computertomographie (SPECT) des Gehirns

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Zusammenfassung

Die ersten Untersuchungen mit der Emissionscomputertomographie (ECT) sind bei zerebrovaskulären Erkrankungen durchgeführt worden [1]. Die Entwicklung hat die nuklearmedizinischen Methoden in den letzten Jahren dramatisch verändert. Es sind verschiedene für die pathophysiologischen Prozesse immer spezifischere Radiopharmaka und für deren Abbildung hochentwickelte tomographische Geräte auf den Markt gekommen. Die Positronenemissionstomographie (PET) ermöglicht es, verschiedene hämodynamische und metabolische Parameter und deren Veränderungen im Verlauf von zerebrovaskulären Erkrankungen in vivo zu erfassen [2, 3]. Während die PET noch immer überwiegend in der Forschung eingesetzt wird, hat die Single-Photon-Emissions- Computertomographie (SPECT) ihren Platz in der breiteren klinischen Anwendung frühzeitig gefunden und weiterhin behauptet.

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Literatur

  1. Lassen NA, Ingvar DH (1972) Radioisotopic assessment of regional cerebral blood flow. Karger, Basel and Univ Park Press, Baltimore Progress Nuclear Medicine 1, pp 376–409

    Google Scholar 

  2. Powers WJ, Raichle ME (1985) Positron emission tomography and its application to the study of cerebrovascular disease in man. Stroke 16:361–376

    Article  PubMed  CAS  Google Scholar 

  3. Heiss W-D, Herholz K (1994) Assessment of pathophysiology of stroke by positron emission tomography. Eur J Nucl Med 21:455–465

    Article  PubMed  CAS  Google Scholar 

  4. Bailey DL, Zito F, Gilardi M-C, Savi AR, Fazio F, Jones T (1994) Performance of a state of the art neuro-SPECT scanner and a dedicated neuro-PET scanner. Eur J Nucl Med 21:381–387

    Article  PubMed  CAS  Google Scholar 

  5. Matsuda H, Tsuji S, Shuke N, Sumiya H, Tonami N, Hisada K (1992) A quantitative approach to technetium-99m hexamethylpropylene amine oxime. Eur J Nucl Med 19:195–200

    Article  PubMed  CAS  Google Scholar 

  6. Pupi A, De Cristofaro MTR, Bacciottini L, Antoniucci D, Formiconi AR, Mascalchi M, Meldolesi U (1991) An analysis of the arterial input curve for technetium-99m-HMPAO: quantification of rCBF using single-photon emission tomography. J Nucl Med 32:1501–1506

    PubMed  CAS  Google Scholar 

  7. Pupi A, Castagnoli A, De Cristofaro MTR, Bacciottini L, Petti AR (1994) Quantitative comparison between 99mTc-HMPAO and 99mTc-ECD: measurement of arterial input and brain retention. Eur J Nucl Med 21:124–130

    Article  PubMed  CAS  Google Scholar 

  8. Andersen AR, Friberg H, Knudsen GM et al. (1988) Extraction of (99mTc)-d, l-HM-PAO across the blood brain barrier. J Cereb Blood Flow Metab 8:S44-S51

    Article  PubMed  CAS  Google Scholar 

  9. Knudsen GM, Andersen AR, Somnier FE, Videbaeck Ch, Hasselbalch S, Paulson OB (1994) Brain extraction and distribution of 99mTc-Bicisate in humans and in rats. J Cereb Blood Flow Metab 14:S12-S18

    Article  PubMed  CAS  Google Scholar 

  10. Knapp WH, Kummer R, Kuebler AW (1986) Imaging of cerebral blood flow to volume distribution using SPECT. J Nucl Med 27:465–470

    PubMed  CAS  Google Scholar 

  11. Buell U, Braun H, Ferbert A, Stirner H, Weiller C, Ringelstein EB (1988) Combined SPECT imaging of regional cerebral blood flow (99mTc-hexamethyl-propyleneamine Oxime, HMPAO) and blood volume (99mTc-RBC) to assess regional cerebral perfusion reserve in patients with cerebrovascular disease. Nucl Med 27:51–56

    CAS  Google Scholar 

  12. Toyama H, Takeshita G, Takeuchi A et al. (1990) Cerebral haemodynamics in patients with chronic obstructive carotid disease by rCBF, rCBV and rCBV/rCBF ratio using SPECT. J Nucl Med 31: 55–60

    PubMed  CAS  Google Scholar 

  13. Pävics L, Kuncz Ä, Ambrus E, Döczi T, Bodosi M, Csernay L (1992) The role of combined rCBF- rCBV SPECT studies in the evaluation of intracranial arteriovenous malformations (AVM-s). In: Schmidt HAE, Höfer R (eds) Nuclear Medicine Schattauer, Stuttgart, pp 438–441

    Google Scholar 

  14. Wallis JW, Miller TR (1991) Three-dimensional display in nuclear medicine and radiology. J Nucl Med 32:534–546

    PubMed  CAS  Google Scholar 

  15. Kung HF, Ohmomo Y, Kung M-P (1990) Current and future radiopharmaceuticals for brain imaging with single photon emission computed tomography. Semin Nucl Med 20:290–302

    Article  PubMed  CAS  Google Scholar 

  16. Winchell HS, Baldwin RM, Lin TH (1980) Development of 1–123 labeled amines for brain studies: localization of 1–123 iodophenylalkyl amines in rat brain. J Nucl Med 21:940–947

    PubMed  CAS  Google Scholar 

  17. Neirinckx RD, Canning LR, Piper IM et al. (1987) Technetium-99m d,I,-HM-PAO: a new radiopharmaceutical for SPECT imaging of regional cerebral blood perfusion. J Nucl Med 28:191-202

    PubMed  CAS  Google Scholar 

  18. Walovitch RC, Hill TC, Garrity ST et al. (1989) Characterization of technetium-99m, L, L-ECD for brain perfusion imaging, part 1: pharmacology of technetium-99m ECD in nonhuman primates. J Nucl Med 30:1892–1901

    PubMed  CAS  Google Scholar 

  19. Hayashida K, Nishimura T, Imakita S, Uehara T (1989) Filling out phenomen with technetium-99m HM-PAO brain SPECT at the site of mild cerebral ischemia. J Nucl Med 30:591–598

    PubMed  CAS  Google Scholar 

  20. Vallabhajosula S, Zimmerman RE, Picard M et al. (1989) Technetium-99m ECD: A new brain imaging agent: In vivo kinetics and biodistribution studies in normal human subjects. J Nucl Med 30:599–604

    PubMed  CAS  Google Scholar 

  21. Croft BY (1990) Instrumentation and computers for brain single photon emission computed tomography. Semin Nucl Med 20:281–289

    Article  PubMed  CAS  Google Scholar 

  22. Ring HA, George M, Costa DC, Ell PJ (1991) The use of cerebral activation procedures with single photon emission tomography. Eur J Nucl Med 18:133–141

    Article  PubMed  CAS  Google Scholar 

  23. Yudd AP, Vafn Heertum RL, Masdeu JC (1991) Interventions and functional brain imaging. Semin Nucl Med 21:153–158

    Article  PubMed  CAS  Google Scholar 

  24. Hayashida K, Hirose Y, Kaminaga T et al. (1993) Detection of postural cerebral hypoperfusion with technetium-99m-HMPAO brain SPECT in patients with cerebrovascular disease. J Nucl Med 34:1931–1935

    PubMed  CAS  Google Scholar 

  25. Nakagawara J, Nakamura J, Takeda R et al. (1994) Assessment of postischemic reperfusion and DIAMOX activation test in stroke using 99mTc-ECD SPECT. J Cereb Blood Flow Metab 14:S49-S57

    Article  PubMed  Google Scholar 

  26. Overbeck B, Rosanowski F, Grünwald F, Bockisch A, von Itter C, Biersack HJ, Herberhold C (1991) HMPAO SPECT unter Karotiskompression (Matas-Test) in der Diagnostik vor zervikalen Tumoreingriffen mit möglicher Karotisbeteiligung. Laryngho-Rhino-Otol 70:422–425

    Article  CAS  Google Scholar 

  27. Maethews D, Walker BS, Purdy PD et al. (1993) Brain blood flow SPECT in temporary balloon occlusion of carotid and intracerebral arteries. J Nucl Med 34:1239–1243

    Google Scholar 

  28. Askienazy S, Lebtahi R, Meder J-F (1993) SPECT HMPAO and balloon test occlusion: Interest in predicting tolerance prior to permanent cerebral artery occlusion. (Editorial) J Nucl Med 34:1243–1245

    PubMed  CAS  Google Scholar 

  29. Palestro CJ, Sen C, Muzinic M, Afriyie M, Goldsmith SJ (1993) Assessing collateral perfusion with technetium-99m-HMPAO SPECT during temporary internal carotid occlusion. J Nucl Med 34:1235–1238

    PubMed  CAS  Google Scholar 

  30. Rieker O, Ries F, Grünwald F et al. (1993) HMPAO- SPECT in the presurgical evaluation of cerebral blood flow during balloon test occlusion with and without acetazolamide. Eur J Nucl Med 20:830 (Abstract)

    Google Scholar 

  31. Holman LB, Devous MD (1992) Functional brain SPECT: The emergence of a powerful clinical method. J Nucl Med 33:1888–1903

    PubMed  CAS  Google Scholar 

  32. Pávics L, Barzó P, Maté E, Ambrus E, Katona É, Morvay Z, Csernay L (1992) Rest and stress (acetazolamide) rCBF-SPECT and transcranial Doppler sonography studies in cerebrovascular disorders. Eur J Nucl Med 19: 594 (Abstract)

    Google Scholar 

  33. Hellman RS, Tikofsky RS (1990) An overview of the contribution of regional cerebral blood flow studies isn cerebrovascular disease: Is there a role for single photon emission computed tomography? Semin Nucl Med 20:303–324

    Article  PubMed  CAS  Google Scholar 

  34. Burt RW, Witt RM, Cikrit DF, Reddy RV (1992) Carotid artery disease: evaluation with Acetazolamide-enhanced 99mTc-HMPAO SPECT. Radiology 182:461–466

    PubMed  CAS  Google Scholar 

  35. Podreka I, Brücke T, Wenger S et al. (1993) Einsatz der SPECT in der Neurologischen Diagnostik. Der Nuklearmediziner 16:99–110

    Google Scholar 

  36. The EC-IC Bypass Study Group (1985) Failure of extracranial-intracranial arterial bypass to reduce the risk of ischemic stroke. N Engl J Med 313:1191–1200

    Article  Google Scholar 

  37. Samson Y, Baron JC, Bousser MG, Rey A, Derlon JM, David P, Comoy J (1985) Effects of extra- intracranial bypass on cerebral blood flow and oxygen metabolism in humans. Stroke 16:609–616

    Article  PubMed  CAS  Google Scholar 

  38. Russel D, Dybevold S, Kjartansson O, Nyberg-Hnasen R, Rootwelt K, Wibweg J (1990) Cerebral vasoreactivity and blood flow before and 3 months after carotid endarterectomy. Stroke 21:1029–1032

    Article  Google Scholar 

  39. Ramsay SC, Yeates MG, Hille N, Yeates P, Eberl P, Reid C, Fernandes V (1991) Use of technetium- HMPAO to demonstrate changes in cerebral blood flow reserve following carotid endarterectomy. J Nucl Med 32:1382–1386

    PubMed  CAS  Google Scholar 

  40. Yeh SH, Liu RS, Hu HH et al. (1986) Brain SPECT imaging with 99mTc-hexamethylpropyleneamine oxime in the early detection of cerebral infarction: comparison with transmission computed tomography. Nucl Med Commun 7:873–878

    Article  PubMed  CAS  Google Scholar 

  41. Podreka I, Suess E, Goldenberg G (1987) Initial experience with technetium-99m HMPAO brain SPECT. J Nucl Med 28:1657–1666

    PubMed  CAS  Google Scholar 

  42. De Roo M, Mortelmans L, Devos P et al. (1989) Clinical experience with 99mTc-HMPAO high resolution SPECT of the brain in patients with cerebrovascular accidents. Eur J Nucl Med 15:9–15

    Article  PubMed  Google Scholar 

  43. Shimosegawa E, Hatazawa J, Inugami A et al. (1994) Cerebral infarction within six hours of onset: Prediction of completed infarction with technetium-99m-HMPAO SPECT. J Nucl Med 35:1097–1103

    PubMed  CAS  Google Scholar 

  44. Feeney DM, Baron J-C (1986) Diaschisis. Stroke 17:817–831

    Article  PubMed  CAS  Google Scholar 

  45. Von-Monakow C [1914, article translated by G. Harris] (1969) In: Pribram KH (ed) Brain and behavior I: Mood states and mind. Penguin, Baltimore, pp 27–36

    Google Scholar 

  46. Biersack HJ, Hartmann A, Friedrich G, Fröscher M, Reichmann K, Reske SN, Knopp R (1984) Zur Ursache der gekreuzten zerebellaren Diaschisis bei zerebrovaskulärer Erkrankung. Nuklearmedizin 23:227–230

    PubMed  CAS  Google Scholar 

  47. Mountz JM, Modell JG, Foster NL et al. (1990) Prognostication of recovery following stroke using the comparison of CT and technetium-99m HM-PAO SPECT. J Nucl Med 31:61–66

    PubMed  CAS  Google Scholar 

  48. Moretti JL, Defer G, Cinotti L et al. (1990) “Luxury perfusion” with 99mTc-HM-PAO and (123I)-IMP SPECT imaging during the subacute phase of stroke. Eur J Nucl Med 16:17–22

    Article  PubMed  CAS  Google Scholar 

  49. Sperling B, Lassen NA (1993) Hyperfixation of HMPAO in subacute ischemic stroke leading to spuriously high estimates of cerebral blood flow by SPECT. Stroke 24:193–194

    Article  PubMed  CAS  Google Scholar 

  50. Brass LM, Walowitch RC, Joseph JL et al. (1994) The role of single photon emission computed tomography brain imaging with 99mTc-Bicisate in the localization and definition of mechanism of ischemic stroke. J Cereb Blood Flow Metab 14:S91-S98

    PubMed  Google Scholar 

  51. Lassen NA, Sperling B (1994) 99mTc-bicisate reliably images CBF in chronic brain disease but fails to show reflow hyperemia in subacute stroke: Report of multicenter trial of 105 cases comparing 133Xe and 99mTc-bicisate (ECD, Neurolite) measured by SPECT on same day. J Cereb Blood Flow Metab 14:S44-S48

    PubMed  Google Scholar 

  52. Tsuchida T, Nishizawa S, Yonekura Y et al. (1993) SPECT images of technetium-99m-ethyl cysteinate dimer in cerebrovascular diseases: Comparison with other cerebral perfusion tracers and PET. J Nucl Med 35:27–31

    Google Scholar 

  53. Pävics L, Döczi T, Bodosi M, Csernay L (1990) 99mTc-HMPAO brain SPECT studies in patients with occlusive disease of the internal carotid artery. Nucl Med 2:85–89

    Google Scholar 

  54. Maini CL, Castellano G, Benech F, Podio V, Cornaglia, Fontanella M (1990) 99mTc-HMPAO brain SPECT in subarachnoid haemorrhage. Nucl Med Commun 11:491–502

    Article  Google Scholar 

  55. Soucy JP, McNamara D, Mohr G, Lamourux F, Danais S (1990) Evaluation of vasospasm secondary to subarachnoid hemorrhage with technetium 99m-hexamethyl-propyleneamine oxime (HMPAO) tomoscintigraphy. J Nucl Med 31:972–977

    PubMed  CAS  Google Scholar 

  56. Lewis DH, Eskridge JM, Newell DW et al. (1992) Brain SPECT and the effect of cerebral angioplasty in delayed ischemia due to vasospasm. J Nucl Med 33:1789–1796

    PubMed  CAS  Google Scholar 

  57. Pävics L, Barzö P, Borda L, Ambrus E, Almasi L, Vörös E, Buga K, Döczi T, Bodosi M, Csernay L (1993) Comparative regional cerebral blood flow (rCBF) SPECT, angiography (DSA) and transcranial Doppler sonography (TCD) studies in the evaluation of vasospasm in subarachnoid hemorrhage (SAH). Eur J Nucl Med 20:821 (Abstract)

    Google Scholar 

  58. Menzel C, Reinhold U, Grünwald F et al. (1994) Cerebral blood flow in Sneddon syndrome. J Nucl Med 35:461–464

    PubMed  CAS  Google Scholar 

  59. Inoue Y, Momose T, Machida K, Honda N, Tsutsumi K (1993) Cerebral vasodilatory capacity mapping using technetium-99m-DTPA-HSA SPECT and acetazolamide in Moyamoya disease. J Nucl Med 34:1984–1986

    PubMed  CAS  Google Scholar 

  60. Buell U, Costa DC, Kirsch G, Moretti JL, Van Royen EA, Schober O (1990) The investigation of dementia with single photon emission tomography. Nucl Med Commun 11:823–841

    PubMed  CAS  Google Scholar 

  61. Bonte FJ, Horn J, Tintner R, Weiner MF (1990) Single photon tomography in Alzheimer’s disease and the dementias. Semin Nucl Med 20:342–352

    Article  PubMed  CAS  Google Scholar 

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  1. L. Pávics
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  1. Abt. Nuklearmedizin, Bundeswehrzentralkrankenhaus Koblenz, Rübenacherstr. 170, 56072, Koblenz, Germany

    H. J. Wieler (Leitender Arzt) (Leitender Arzt)

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Pávics, L. (1995). SPECT bei zerebrovaskulären Erkrankungen. In: Wieler, H.J. (eds) Single-Photon-Emissions-Computertomographie (SPECT) des Gehirns. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79222-9_9

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  • DOI: https://doi.org/10.1007/978-3-642-79222-9_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79223-6

  • Online ISBN: 978-3-642-79222-9

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