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Multiple Dopamine Receptors: Implications for Schizophrenia

  • Conference paper
Search for the Causes of Schizophrenia

Abstract

The classical dopamine (DA) hypothesis of schizophrenia owed its birth to the serendipitous discovery in the early 1950s of the potent antipsychotic properties of chlorpromazine (Delay et al. 1952). The ability of this compound, as well as other related “neuroleptics”, to increase animal brain levels of DA metabolites in rough proportion to their clinical efficacy had been attributed to blockade of, at this time still undiscovered, brain DA receptors (Carlsson and Lindqvist 1963). Conversely, it was hypothesized that overstimulation of these receptors could be involved in the etiology of the disorder. In support were the observations that DA-stimulant drugs such as amphetamine were able to induce psychosis-like manifestations in healthy individuals or to exacerbate psychotic symptoms in schizophrenics. The subsequent discovery that therapeutic potencies of antipsychotics were correlated with their affinity for certain brain DA receptors (Creese et al. 1976) has added arguable value to the hypothesis.

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  1. Unité de Neurobiologie et de Pharmacologie de I’INSERM, Centre Paul Broca, 2ter rue d’Alésia, 75014, Paris, France

    P. Sokoloff, M.-P. Martres, C. Pilon, N. Griffon & J.-C. Schwartz

  2. Laboratoire de Physiologie, Université René Descartes, 4 Avenue de l’Observatoire, 75006, Paris, France

    J. Diaz

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Sokoloff, P. et al. (1995). Multiple Dopamine Receptors: Implications for Schizophrenia. In: Häfner, H., Gattaz, W.F. (eds) Search for the Causes of Schizophrenia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79429-2_12

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